Structural Analysis of an Epitope Candidate of Triosephosphate Isomerase in Opisthorchis viverrini [PDF]
Scientific Reports, 2018 Opisthorchis viverrini, a parasitic trematode, was recategorized as a group 1 biological carcinogen because it causes opisthorchiasis, which may result in cholangiocarcinoma. A new strategy for controlling opisthorchiasis is needed because of issues such
Jonghyeon Son +5 more
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Scientific Reports, 2017 Giardiasis is a worldwide parasitic disease that affects mainly children and immunosuppressed people. Side effects and the emergence of resistance over current used drugs make imperative looking for new antiparasitics through discovering of new ...
B. Hernández-Ochoa +15 more
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Triosephosphate Isomerase: The Crippling Effect of the P168A/I172A Substitution at the Heart of an Enzyme Active Site. [PDF]
Biochemistry, 2023 Hegazy R, Richard JP.
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PLoS Genetics, 2016 Triosephosphate isomerase (TPI) deficiency is a poorly understood disease characterized by hemolytic anemia, cardiomyopathy, neurologic dysfunction, and early death.
B. Roland +9 more
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Triosephosphate Isomerase Deficiency: E105D Mutation in Unrelated Patients and Review of the Literature. [PDF]
Mol Syndromol, 2023 Selamioğlu A +7 more
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Endoglucanase activity at a second site in Pyrococcus furiosus triosephosphate isomerase-Promiscuity or compensation for a metabolic handicap? [PDF]
FEBS Open Bio, 2017 The eight‐stranded (β/α)8 barrel fold known as the Triosephosphate isomerase (TIM) barrel is the most commonly observed fold in enzymes, displaying an eightfold structural symmetry.
Sharma P, Guptasarma P.
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The Role of Asn11 in Catalysis by Triosephosphate Isomerase. [PDF]
Biochemistry, 2023 Four catalytic amino acids at triosephosphate isomerase (TIM) are highly conserved: N11, K13, H95, and E167. Asparagine 11 is the last of these to be characterized in mutagenesis studies. The ND2 side chain atom of N11 is hydrogen bonded to the O-1 hydroxyl of enzyme-bound dihydroxyacetone phosphate (DHAP), and it sits in an extended chain of hydrogen ...
Hegazy R +3 more
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Species-Specific Inactivation of Triosephosphate Isomerase from Trypanosoma brucei: Kinetic and Molecular Dynamics Studies [PDF]
Molecules, 2017 Human African Trypanosomiasis (HAT), a disease that provokes 2184 new cases a year in Sub-Saharan Africa, is caused by Trypanosoma brucei. Current treatments are limited, highly toxic, and parasite strains resistant to them are emerging. Therefore, there
Alejandra Vázquez-Raygoza +12 more
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Glycolysis- and immune-related novel prognostic biomarkers of Ewing's sarcoma: glucuronic acid epimerase and triosephosphate isomerase 1. [PDF]
Aging (Albany NY), 2021 Jiang J +12 more
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Journal of Biological Chemistry, 1985 Nine cDNA clones of human adult liver triosephosphate (TP) isomerase have been isolated and characterized. All nine appear to be derived from a single mRNA species. DNA sequencing of one clone, designated pHTPI-5a, defined the last two nucleotides of the methionine initiation codon, the entire 744-nucleotide coding region of the mature polypeptide, and
Lynne E. Maquat +2 more
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