Perturbation of the Dimer Interface of Triosephosphate Isomerase and its Effect on Trypanosoma cruzi [PDF]
, 2007 Chagas disease affects around 18 million people in the American continent. Unfortunately, there is no satisfactory treatment for the disease. The drugs currently used are not specific and exert serious toxic effects.
Vanesa Olivares‐Illana +9 more
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Resveratrol modulates triosephosphate isomerase and mineralization in osteosarcoma cells: potential target for novel therapeutic strategies. [PDF]
Turk J BiolTuna G +4 more
europepmc +2 more sources
In Vitro Evaluation of Esters of Quinoxaline-1,4-di-<i>N-</i>oxide Derivatives as New Antitaeniasis Agents and Their Inhibitory Activity Against Triosephosphate Isomerase. [PDF]
Pharmaceuticals (Basel)Palomares-Alonso F +8 more
europepmc +2 more sources
Computer Simulation of the Triosephosphate Isomerase Catalyzed Reaction [PDF]
Journal of Biological Chemistry, 1996 A major challenge for theoretical simulation methods is the calculation of enzymic reaction rates directly from the three-dimensional protein structure together with some idea of the chemical reaction mechanism. Here, we report the evaluation of a complete free energy profile for all the elementary steps of the triosephosphate isomerase catalyzed ...
Johan Åqvist, Michael Fothergill
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Differential Proteomic Analysis of Human Saliva using Tandem Mass Tags Quantification for Gastric Cancer Detection. [PDF]
, 2016 Novel biomarkers and non-invasive diagnostic methods are urgently needed for the screening of gastric cancer to reduce its high mortality. We employed quantitative proteomics approach to develop discriminatory biomarker signatures from human saliva for ...
Cao, Cheng-Xi +9 more
core +15 more sources
Characterization of human triosephosphate isomerase S-nitrosylation.
Nitric Oxide, 2018 Triosephosphate isomerase (TPI), the glycolytic enzyme that catalyzes the isomerization of dihydroxyacetone phosphate (DHAP) to glyceraldehyde-3-phosphate (G3P), has been frequently identified as a target of S-nitrosylation by proteomic studies. However, the effect of S-nitrosylation on its activity has only been explored in plants and algae.
J. M. Romero, M. E. Carrizo, J. Curtino
semanticscholar +5 more sources
Triosephosphate Isomerase of Pea Seeds [PDF]
Plant Physiology, 1965 Triosephosphate isomerase catalyzes the reversible transformation of D-glyceralydehyde-3-phosphate and dihydroxyacetone phosphate. This enzyme, together with aldolase was shown by Meyerhof and Kiessling (9) to form the zymohexase system of rabbit muscle and yeast extracts (10).
Martin Gibbs +3 more
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Child Neurology: Triosephosphate isomerase deficiency [PDF]
Neurology, 2020 Triosephosphate isomerase (TPI) deficiency is a rare autosomal recessive disease of infancy and childhood classified as a glycolytic enzymopathy. Clinical features include hemolytic anemia, progressive neuromuscular dysfunction, and increased susceptibility to infection with specific pathogenic variants resulting in severe disease and death by age 8 ...
Ronald Morton +6 more
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Prenatal diagnosis of triosephosphate isomerase deficiency [PDF]
Blood, 1996 First-trimester prenatal diagnosis was undertaken by chorionic villus DNA analysis in two unrelated families with the inherited glycolytic disorder triosephosphate isomerase (TPI) deficiency. The propositus in each family was shown to be homozygous for a missense mutation (GAG --> GAC) at codon 104 of the TPI gene.
Kypros H. Nicolaides +4 more
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Comparative transcriptomics and bioinformatics analysis of genes related to photosynthesis in Eucalyptus camaldulensis [PDF]
PeerJ, 2022 The timber species Eucalyptus camaldulensis is one of the most important in southern China. Therefore, it is essential to understand the photosynthetic pattern in eucalyptus leaves.
Ni Zhan +6 more
doaj +2 more sources