Triosephosphate isomerase deficiency in an infant
Triosephosphate isomerase deficiency is an autosomal recessive disorder characterized by progressive neuromuscular degeneration, seizure, dystonia, weak muscles, cardiomyopathy, hemolytic anemia, and death in early childhood. In the glycolytic pathway, dihydroxy acetone phosphate (DHAP) is converted to glyceraldehyde-3-phosphate by an enzymatic ...
Merve KARACA+11 more
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Temperature Fluctuations Affected the Activity of Triosephosphate Isomerase by Regulating Phosphorylation and Nitrosylation [PDF]
In this study, triosephosphate isomerase was incubated in the presence of exogenous protein kinase A and S-nitrosoglutathione to elucidate the regulatory effects of phosphorylation and nitrosylation on the enzyme’s activity as a function of incubation ...
WU Saisai, WANG Zhenyu, BAI Yuqiang, HOU Chengli, RAO Weili, LI Xin, ZHANG Zhisheng, ZHANG Dequan
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The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo [PDF]
Human lymphatic filariasis is a major tropical disease transmitted through mosquito vectors which take up microfilarial larvae from the blood of infected subjects.
A Ationu+68 more
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Triosephosphate isomerase (286 aa, ~31 kDa) is encoded by the human TPI1 gene. This protein plays a role in the isomerization of glyceraldehydes in both glycolysis and gluconeogenesis.
P. Sears
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Mechanism study of alachlor biodegradation by Paecilomycesmarquandii with proteomic and metabolomic methods [PDF]
Alachlor is an herbicide that is widely used worldwide to protect plant crops against broadleaf weedsand annual grasses. However, due to its endocrine-disrupting activity, its application had been bannedin the European Union.
Adrian Soboń+42 more
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Differential neuroproteomic and systems biology analysis of spinal cord injury [PDF]
Acute spinal cord injury (SCI) is a devastating condition with many consequences and no known effective treatment. Although it is quite easy to diagnose traumatic SCI, the assessment of injury severity and projection of disease progression or recovery ...
Bramlett, Helen M+8 more
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Phenotypic and Target-Directed Screening Yields New Acaricidal Alternatives for the Control of Ticks
Rhipicephalus microplus, the “common cattle tick”, is the most important ectoparasite in livestock worldwide due to the economic and health losses it produces. This tick is a vector for pathogens of several tick-borne diseases.
Tatiana Saporiti+11 more
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A Potential Role for the Interaction of Wolbachia Surface Proteins with the Brugia malayi Glycolytic Enzymes and Cytoskeleton in Maintenance of Endosymbiosis [PDF]
The human filarial parasite Brugia malayi harbors an endosymbiotic bacterium of the genus Wolbachia. The Wolbachia represent an attractive target for the control of filarial induced disease as elimination of the bacteria affects molting, reproduction and
Bell, Aaron J.+7 more
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Autoantibodies in Post-Epstein-Barr Acute Cerebellar Ataxia
Eight of 23 patients with acute cerebellar ataxia (ACA) following Epstein-Barr virus (EBV) infection (proven serologically) had increased IgM anti-triosephosphate isomerase (TPI) antibody titers, in a study at Kyorin University, Tokyo, and Kinki ...
J Gordon Millichap
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Regulation of SESAME-mediated H3T11 phosphorylation by glycolytic enzymes and metabolites. [PDF]
Cancer cells prefer aerobic glycolysis, but little is known about the underlying mechanism. Recent studies showed that the rate-limiting glycolytic enzymes, pyruvate kinase M2 (PKM2) directly phosphorylates H3 at threonine 11 (H3T11) to regulate gene ...
Qi Yu+10 more
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