Tetrameric triosephosphate isomerase from hyperthermophilic Archaea [PDF]
FEBS Letters, 1996 Triosephosphate isomerase (TIM) of the hyperthermophilic Archaea Pyrococcus woesei and Methanothermus fervidus have been purified to homogeneity. The enzymes from the two hyperthermophiles represent homo‐tetramers of 100 kDa, contrary to all known bacterial and eukaryotic TIMs, which are dimers of 48–60 kDa. Molecular size determination of the TIM from
Kohlhoff, Michael +2 more
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Methylglyoxal Produced by Amyloid- Peptide-Induced Nitrotyrosination of Triosephosphate Isomerase Triggers Neuronal Death in Alzheimer’s Disease [PDF]
, 2014 Amyloid-β peptide (Aβ) aggregates induce nitro-oxidative stress, contributing to the characteristic neurodegeneration found in Alzheimer's disease (AD).
Boada, M. +15 more
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Perturbation of the dimer interface of triosephosphate isomerase and its effect on trypanosoma cruzi [PDF]
, 2016 Chagas disease affects around 18 million people in the American continent. Unfortunately, there is no satisfactory treatment for the disease. The drugs currently used are not specific and exert serious toxic effects.
Becker, Ingeborg +9 more
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iScience, 2021 Summary: Viruses depend on the host metabolic machinery to complete their life cycle in the host cytoplasm. However, the key viral factors initiating the host machinery after the virus enters the cytoplasm remain unclear.
Siyuan Zhang, Fan Xin, Xiaobo Zhang
doaj +1 more source
Proteomic responses reveal the differential effects induced by cadmium in mussels Mytilus galloprovincialis at early life stages [PDF]
, 2016 Cadmium (Cd) has become an important metal contaminant and posed severe risk on the organisms in the coastal environments of the Bohai Sea. Marine mussel Mytilus galloprovincialis is widely distributed along the Bohai coast and consumed as seafood by ...
Ji, CL +6 more
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Comparative analysis of inflamed and non-inflamed colon biopsies reveals strong proteomic inflammation profile in patients with ulcerative colitis [PDF]
, 2012 Background Accurate diagnostic and monitoring tools for ulcerative colitis (UC) are missing. Our aim was to describe the proteomic profile of UC and search for markers associated with disease exacerbation.
A Shkoda +55 more
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The effects of photodynamic treatment with new methylene blue N on the Candida albicans proteome. [PDF]
, 2016 Candida albicans is a human pathogenic fungus mainly affecting immunocompromised patients. Resistance to the commonly used fungicides can lead to poor treatment of mucosal infections which, in turn, can result in life-threatening systemic candidiasis. In
Braga, GÚL +7 more
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The return of metabolism: biochemistry and physiology of the pentose phosphate pathway. [PDF]
, 2014 The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism. The PPP is important to maintain carbon homoeostasis, to provide precursors for nucleotide and amino acid biosynthesis, to provide reducing molecules for anabolism ...
Breitenbach, Michael +14 more
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Substrate Effect on Catalytic Loop and Global Dynamics of Triosephosphate Isomerase
Entropy, 2013 The opening/closure of the catalytic loop 6 over the active site in apo triosephosphate isomerase (TIM) has been previously shown to be driven by the global motions of the enzyme, specifically the counter-clockwise rotation of the subunits. In this work,
Pemra Doruker, Zeynep Kurkcuoglu
doaj +1 more source
Modeling of the Glycolysis Pathway in Plasmodium falciparum using Petri Nets [PDF]
, 2016 Malaria is one of the deadly diseases, which affects a large number of the world’s population. The Plasmodium falciparum parasite during erythrocyte stages produces its energy mainly through anaerobic glycolysis, with pyruvate being converted into ...
Isewon, Itunuoluwa +3 more
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