Results 11 to 20 of about 256 (147)

The fluorescence‐based competitive counterflow assay developed for organic anion transporting polypeptides 1A2, 1B1, 1B3 and 2B1 identifies pentamidine as a selective OATP1A2 substrate

The FASEB Journal, Volume 37, Issue 11, November 2023., 2023
The fluorescent competitive counterflow assay can distinguish between substrates and non‐transported inhibitors of Organic anion transporting polypeptides. Substrates trigger efflux or the fluorescent probe from the cells. With this method, we identify the FDA‐approved antiprotozoal drug pentamidine as a selective OATP1A2 substrate. OATP1A2 can mediate
Orsolya Ungvári, Éva Bakos, Daniella Kovacsics, Csilla Özvegy‐Laczka   +3 more
wiley   +1 more source

Discovery of Antitrypanosomal Indolylacetamides by a Deconstruction–Optimization Strategy Applied to Paullones

ChemMedChem, Volume 18, Issue 10, May 16, 2023., 2023
Treatment of Chagas disease, African sleeping sickness and Leishmaniasis is currently limited to few, unfavorable drugs. We discovered novel antitrypanosomal compounds via molecular simplification of an original molecule (MOL2008) displaying limited selectivity.
Jens C. Lindhof, Irina Ihnatenko, Marco J. Müller, Oliver C. F. Orban, Cecilia Ortíz, Diego Benítez, Estefanía Dibello, Leonardo L. Seidl, Marcelo A. Comini, Conrad Kunick   +9 more
wiley   +1 more source

The avirulence of the cultivated Y strain of Trypanosoma cruzi: IV. The effect of immunosuppressive agents in mice

Revista da Sociedade Brasileira de Medicina Tropical, 1971
Drogas imunossupressoras (Azathioprina e Methotrexato) que se mostraram capazes de agravar infecções experimentais por Trypanosoma cruzi virulento (cepa Y), em camundongos, não conseguiram favorecer o aparecimento de qualquer sinal de infecção em animais
Humberto Menezes
doaj   +1 more source

Polineuropatias chagasicas

Arquivos de Neuro-Psiquiatria, 1979
São apresentados os resultados obtidos em pesquisa "cega" realizada na área de São Felipe (BA), num total de 99 pacientes, sendo 50 com MG reagente e 49 com MG não reagente.
J. Fortes-Rego
doaj   +1 more source

Proteinogramas séricos de ratos Wistar experimentalmente infectados com Trypanosoma evansi Serum protein concentrations in Wistar rats experimentally infected with Trypanosoma evansi

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2008
Estabeleceu-se o perfil eletroforético de proteínas séricas de ratos Wistar experimentalmente infectados com Tripanosoma evansi, utilizando-se 40 ratos, distribuídos em oito grupos de cinco animais cada.
M.C.A. Teixeira, L.C. Marques, F.A. Cadioli, J.J. Fagliari, R.Z. Machado, P.C. Silva   +5 more
doaj   +1 more source

Chronic intestinal pseudo‐obstruction in adults: A practical guide to identify patient subgroups that are suitable for more specific treatments

Neurogastroenterology &Motility, Volume 36, Issue 1, January 2024.
Abstract Chronic intestinal pseudo‐obstruction is a rare and heterogeneous syndrome characterized by recurrent symptoms of intestinal obstruction with radiological features of dilated small or large intestine with air/fluid levels in the absence of any mechanical occlusive lesion.
Guido Basilisco, Margherita Marchi, Marina Coletta   +2 more
wiley   +1 more source

Studies on Trypanosoma rangeli Tejera 1920. IV - A reconsideration of its systematic position

Memorias do Instituto Oswaldo Cruz, 1982
The systematic positon of Trypanosoma rangeli is reconsidered and the creation of a new subgenus. Tejeraia, is proposed to remove this trypanosome from the subgenus Herptosoma of the section Stercoraria.
N. Añez
doaj   +1 more source

Anothor Trypanosoma, distinct from T. cruzi, multiplies in the lumen of the anal glands the opossum Didelphis marsupialis

Memorias do Instituto Oswaldo Cruz, 1986
Epimastigotes were found multiplying in the anal glands and in hemocultures of an opossum; rare metacyclics were seen in the cultures. The flagellate is possibly T. (Megatrypanum) freitasi Rego, Magalhães & Siqueira, 1957, but its final identification is
Maria P. Deane, Ana Maria Jansen
doaj   +1 more source

Tripanosomas que infectan mamíferos: estado del arte en Ecuador y recomendaciones para su estudio

Mammalia aequatorialis, 2021
Trypanosoma brucei and T. cruzi are parasites of medical interest because of the diseases they cause in humans and domestic mammals. However, these and many more species of trypanosomes also infect wild mammals, and their study is important to: 1) understand the overlap between domestic and sylvatic transmission cycles; 2) comprehend the evolutionary ...
openaire   +1 more source

Trypanosoma lambrechti n. sp. aislado de micos (cebus albifrons) de Colombia Trypanosoma lambrechti n. sp. aislado de micos (cebus albifrons) de Colombia

Caldasia, 1968
En un estudio en sangre de micos colombianos, pertenecientes a 13 especies diferentes, 3 de 12 Cebus albifrons hospedaban en su sangre periférica un número muy bajo de Trypanosoma lambrechti n. sp.
Marinkelle C. J.
doaj