Results 121 to 130 of about 10,083 (229)

Adaptive Responses of Tropical Crops: A Multi‐Scale Omics Integrated Perspective

Advanced Science, EarlyView.
Tropical crops integrate genomic, morphological, physiological, and ecological adaptations to thrive under extreme and variable environments. This review highlights how natural selection, domestication, and breeding shape stress resilience, resource‐use strategies, and productivity in sugarcane, banana, cassava, rubber and oil palm, offering new routes
Peilin Wang, Chenhui Li, Dongjiao Wang, Qibin Wu, Zhen Zeng, Huiming Guo, Han Cheng, Songbi Chen, Hongxing Cao, Hongmei Cheng, Jianghui Xie, Youxiong Que   +11 more
wiley   +1 more source

Multi-omics dissection of R-loop dynamics in tumorigenesis: From transcription-replication conflict to therapeutic targets. [PDF]

Mol Ther Oncol
Zhang Y, Xiong N, Song Y, Lu X, Ni K, Tang Z.   +5 more
europepmc   +1 more source

Critically Generated Knowledge – the Triple Loop Learning Result

Management - Journal for theory and practice of management, 2012
openaire   +1 more source

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, EarlyView.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

Thermodynamic prediction of RNA cellular activity from sequence via conformational ensembles. [PDF]

Cell
Geng A, Roy R, Ken M, Li L, Chime A, Abou Assi H, Liu B, Bou-Nader C, Lee Y, Zhang J, Herschlag D, Goff SP, Al-Hashimi HM.   +12 more
europepmc   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Computational optimization of DEK1 calpain domain solubility through integrated structural modelling and data-driven targeted mutagenesis. [PDF]

Sci Rep
Dabiri M, Levarski Z, Struhárňanská E, Demko V, Beneš V, Turňa J, Stuchlík S.   +6 more
europepmc   +1 more source

Gas Sensing With Aerogels: A Critical Review on Structure‐Property Correlations and Performance Optimization

Advanced Science, EarlyView.
With high specific surface area, and adjustable interface, aerogel provides a multi‐functional platform for gas sensing. This review systematically links structural parameters (specific surface area, pore size, heterojunctions) to sensing metrics (sensitivity, selectivity, stability), critically evaluates optimization strategies, and outlines future ...
Hao Guo, Linheng He, Qinxin Wang, Man Yuan, Shoutian Qiu, Wei Liu, Sheng Cui   +6 more
wiley   +1 more source

Closing the loop: human-augmented, mechanistically enhanced AI for proactive management of drug-drug interactions. [PDF]

Front Pharmacol
Spanakis M, De Pauw A, Brumer M, Symvoulakis EK, De Loof H.   +4 more
europepmc   +1 more source

Surface and Interfacial Engineering toward Durable Mechanically Coupled Flexible Electronics

Advanced Science, EarlyView.
This Review highlights how surface and interfacial engineering governs the reliability, durability, and functional stability of mechanically coupled flexible electronics. By integrating fundamental interfacial theory, failure mechanisms, multiscale engineering strategies, and representative applications, it provides a design‐oriented framework for ...
Qian Wang, Fangfang Dai, Wei Wu
wiley   +1 more source