Results 91 to 100 of about 171,342 (310)

Triple-Negative Breast Cancer Coexisting with Adenomyoepithelioma: A Case Report

Journal of the Korean Society of Radiology
Adenomyoepithelioma (AME) is a rare breast tumor characterized by the proliferation of both inner epithelial and outer myoepithelial cells. Here, we report a case of AME coexisting with triple-negative breast cancer (TNBC) in a 55-year-old woman ...
Sang Ah Cho, Jin Chung, Ji Min Kim, Sun Hee Sung, Eun Suk Cha, Jeoung Hyun Kim   +5 more
doaj   +1 more source

Immunophenotype and evolution of breast carcinomas: a comparison between very young and postmenopausal women [PDF]

, 2009
OBJETIVO: avaliar características clínicas, patológicas e moleculares de carcinomas mamários em mulheres muito jovens em comparação a tumores de mulheres na pós-menopausa.
ANDRADE, Victor Piana de, DUTRA, Mara Costa, GOBBI, Helenice, PAULA, Élbio Cândido de, REZENDE, Marina Alvarenga, RIBEIRO, Márcio Ventura, SOARES, Fernando Augusto   +6 more
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Synthesis of Curcumin Derivatives and Analysis of Their Antitumor Effects in Triple Negative Breast Cancer (TNBC) Cell Lines [PDF]

, 2019
We analyzed antitumor effects of a series of curcumin analogues. Some of them were obtained by reaction of substitution involving the two phenolic OH groups of curcumin while the analogues with a substituent at C-4 was prepared following an original ...
Barattucci A, Bonaccorsi PM, Labbozzetta M, Notarbartolo M, Poma P, Salerno TMG   +5 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Association of invasive breast carcinoma and multicentric high grade astrocytoma: a case report with a review. [PDF]

, 2011
Breast cancer is the most common cancer in women. Multicentric gliomas are uncommon lesions of the central nervous system (CNS) with an unprecise rate of occurrence that diffusely infiltrate large portions of the brain. High grade astrocytoma is the most
Forouzandeh, M., Hoseinpour, P., Hossein Pour, P., Naderi Beni, Afsaneh., Naderi Beni, Zahra.   +4 more
core   +1 more source

Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas [PDF]

, 2018
Adenomyoepithelioma of the breast is a rare tumor characterized by epithelial-myoepithelial differentiation, of which a subset will progress to invasive or metastatic cancer. We sought to define the genomic landscape of adenomyoepitheliomas.
A McKenna, A Raouf, AC Wolff, AW Moritz, B Han, B Weigelt, C Curtis, C Jones, C Nogueira, Cancer Genome Atlas, N., CK Ng, CK Ng, CKY Ng, CKY Ng, CM Nadelman, CT Saunders, CW Elston, D Lazard, DA Landau, DC Koboldt, DK Carroll, E Castellano, E Sinn, F Pareja, G Ciriello, G Dontu, G Jonsson, G Molyneux, H Li, H Li, I Grunewald, I Weinreb, J Debnath, JE Visvader, JG Reiter, JK Cowell, JP Gustin, JS Reis-Filho, K Cibulskis, K Podsypanina, L Hernandez, LG Martelotto, LG Martelotto, M Kok, M Persson, M Shiraki, M Yu, MA Deugnier, MD Leiserson, ME Hammond, MM Hayes, MT Chang, P Lebok, PA Kenny, R Shen, S Chiang, S Koren, S Maruya, S Nik-Zainal, S Piscuoglio, S Piscuoglio, SI Chiosea, SL Carter, SR Lakhani, T Kurita, X Su, Y Li, Z Gatalica   +67 more
core   +6 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Clonal heterogeneity as a driver of disease variability in the evolution of myeloproliferative neoplasms. [PDF]

, 2014
Myeloproliferative neoplasms (MPNs) are clonal hematological diseases in which cells of the myelo-erythroid lineage are overproduced and patients are predisposed to leukemic transformation.
de Haan, Gerald, Green, Anthony R, Kent, David G, Prick, Janine   +3 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source