Results 71 to 80 of about 171,342 (310)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Sociodemographic Profile, Reproductive Factors and Presentation Pattern in Breast Cancer Patients from North India: A Hospital Based Study

Journal of Pharmacy and Bioallied Sciences
Background: Breast cancer is leading cause of cancer in women globally and in India, with rising incidence seen specially in North India. Aim was to evaluate sociodemographic, reproductive factors, presentation pattern and surgical complications among ...
Ambuj Kumar Soni, Ajeet Shukla, Kanhaiya Baghel, Shafiqa Haris   +3 more
doaj   +1 more source

Detection of Methylated Circulating DNA as Noninvasive Biomarkers for Breast Cancer Diagnosis [PDF]

, 2017
Internationally, breast cancer is the most common female cancer, and is induced by a combination of environmental, genetic, and epigenetic risk factors.
Cheuk, WY, Kwong, A, Shin, VY
core   +1 more source

Immunopathological Mechanisms Observed in the Intratumoral Microenvironment and Their Relationship with Worse Prognosis in Triple-Negative Breast Cancer

Archives of Breast Cancer
Background: In the 21st century, the main cause of death in both sexes worldwide is cardiovascular disease, followed by neoplasms. In women, the main cause of morbidity and mortality is breast cancer. Therefore, understanding the immunological mechanisms
Josué Mondragón Morales, Rogelio Rogel-Alvarado, Iris Alejandra Noverón-Figueroa, Max Morales-Gutierrez   +3 more
semanticscholar   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Importance of Nectin2, NUF2, and Nectin4 Gene Expression in the Pathogenesis of Different Subtypes of Breast Cancer [PDF]

Middle East Journal of Cancer
Background: The targeted therapy using breast cancer (BC)-associated biomarkers has significantly minimized the side-effects of BC treatment. This study aims to elucidate the role of Nectin2, NUF2, and Nectin4 gene expression in the pathogenesis of BC ...
Zahra Roshanizadeh, Mohammad Reza Haghshenas, Amin Ramezani, Neda Shajari, Sedigheh Tahmasebi, Majid Akrami, Abbas Ghaderi   +6 more
doaj   +1 more source

microRNA. Diagnostic Perspective [PDF]

, 2015
Biomarkers are biological measures of a biological state. An ideal marker should be safe and easy to measure, cost efficient, modifiable with treatment, and consistent across gender and ethnic groups. To date, none of the available biomarkers satisfy all
FARUQ, MD OMAR, VECCHIONE, ANDREA
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Mesothelin expression in triple negative breast carcinomas correlates significantly with basal-like phenotype, distant metastases and decreased survival. [PDF]

PLoS ONE, 2014
Mesothelin is a cell surface associated antigen expressed on mesothelial cells and in some malignant neoplasms. Mesothelin-targeted therapies are in phase I/II clinical trials. The clinicopathologic and prognostic significance of mesothelin expression in
Gary Tozbikian, Edi Brogi, Kyuichi Kadota, Jeffrey Catalano, Muzaffar Akram, Sujata Patil, Alice Y Ho, Jorge S Reis-Filho, Britta Weigelt, Larry Norton, Prasad S Adusumilli, Hannah Yong Wen   +11 more
doaj   +1 more source

Roles of eIF3m in the tumorigenesis of triple negative breast cancer

Cancer Cell International, 2020
Without targets, triple negative breast cancer (TNBC) has the worst prognosis in all subtypes of breast cancer (BC). Recently, eukaryotic translation initiation factor 3 m (eIF3m) has been declared to be involved in the malignant progression of various ...
W. Han, Cong Zhang, Chun-Tao Shi, Xiao-jiao Gao, Ming-hui Zhou, Qingchun Shao, Xiaowei Shen, Cheng-jiang Wu, Fang Cao, Yong-wei Hu, Jian-Liang Yuan, Hou-zhong Ding, Qing-hua Wang, Hao-nan Wang   +13 more
semanticscholar   +1 more source