Results 51 to 60 of about 164,343 (265)

Adenosquamous Variant of Metaplastic Carcinoma of Breast – An Unusual Histological Variant [PDF]

Journal of Clinical and Diagnostic Research, 2015
Metaplastic carcinoma of breast refers to a heterogeneous group of neoplasms characterized by intimate admixture of adenocarcinoma with dominant areas of spindle cell, squamous cell and/ or mesenchymal differentiation.
P.U.Swathy, P.Arunalatha, K.Chandramouleeswari, S.Mary Lily, S.Ramya   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Polyphenols as Promising Drugs against Main Breast Cancer Signatures

Antioxidants, 2017
Breast cancer is one of the most common neoplasms worldwide, and in spite of clinical and pharmacological advances, it is still a clinical problem, causing morbidity and mortality. On the one hand, breast cancer shares with other neoplasms some molecular
María Losada-Echeberría, María Herranz-López, Vicente Micol, Enrique Barrajón-Catalán   +3 more
doaj   +1 more source

Immunopathological Mechanisms Observed in the Intratumoral Microenvironment and Their Relationship with Worse Prognosis in Triple-Negative Breast Cancer

Archives of Breast Cancer
Background: In the 21st century, the main cause of death in both sexes worldwide is cardiovascular disease, followed by neoplasms. In women, the main cause of morbidity and mortality is breast cancer. Therefore, understanding the immunological mechanisms
Josué Mondragón Morales, Rogelio Rogel-Alvarado, Iris Alejandra Noverón-Figueroa, Max Morales-Gutierrez   +3 more
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Androgen receptor expression in triple-negative breast cancer: A retrospective cross-sectional study from South India

Asian Journal of Medical Sciences
Background: Triple-negative breast carcinoma (TNBC) lacks established hormonal targets, limiting therapeutic options. Androgen receptor (AR) expression has been proposed as a potential biomarker, though its clinicopathological relevance remains unclear.
Kavitha S , Johnraj Suresh M , Narayana Vadivoo R   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Carcinoma en Cuirasse: A Rare Entity in Young Women [PDF]

Journal of Clinical and Diagnostic Research
Carcinoma en Cuirasse is a rare form of cutaneous metastasis most commonly associated with advanced breast carcinoma. It is characterised by diffuse dermal infiltration resulting in indurated, sclerodermoid thickening of the skin, because of its rarity ...
Mahe Falak Naz, Kewecho Akami, Neikhrietsonuo Kesiezie, Visar Linyu, Shikha Prabhu Lawande   +4 more
doaj  

Sociodemographic Profile, Reproductive Factors and Presentation Pattern in Breast Cancer Patients from North India: A Hospital Based Study

Journal of Pharmacy and Bioallied Sciences
Background: Breast cancer is leading cause of cancer in women globally and in India, with rising incidence seen specially in North India. Aim was to evaluate sociodemographic, reproductive factors, presentation pattern and surgical complications among ...
Ambuj Kumar Soni, Ajeet Shukla, Kanhaiya Baghel, Shafiqa Haris   +3 more
doaj   +1 more source