Results 61 to 70 of about 101,408 (263)

Importance of Nectin2, NUF2, and Nectin4 Gene Expression in the Pathogenesis of Different Subtypes of Breast Cancer [PDF]

Middle East Journal of Cancer
Background: The targeted therapy using breast cancer (BC)-associated biomarkers has significantly minimized the side-effects of BC treatment. This study aims to elucidate the role of Nectin2, NUF2, and Nectin4 gene expression in the pathogenesis of BC ...
Zahra Roshanizadeh, Mohammad Reza Haghshenas, Amin Ramezani, Neda Shajari, Sedigheh Tahmasebi, Majid Akrami, Abbas Ghaderi   +6 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Effectiveness of Transcatheter Arterial Embolization in Locally Advanced Triple- Negative Breast Cancer Resistant to Neoadjuvant Chemotherapy: A Case Report

Journal of the Korean Society of Radiology
A 74-year-old woman was diagnosed with locally advanced invasive ductal carcinoma of the right breast, which was confirmed as triple-negative breast cancer (TNBC) by immunohistochemical analysis. Multiple ipsilateral axillary lymph node metastases were
Seo Ha Park, Keong Won Yun, Ga Young Yoon, Youngjong Cho, Seungeun Kim   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Triple-negative vimentin-positive heterogeneous feline mammary carcinomas as a potential comparative model for breast cancer. [PDF]

, 2014
BackgroundHuman breast cancer is a heterogeneous disease classified by molecular subtyping into luminal A, luminal B, HER2-overexpressing, basal-like, claudin-low and normal-breast like.
CARDAZZO, BARBARA, Goldschmidt MH, CASTAGNARO, MASSIMO, Valentina Zappulli, Massimo Castagnaro, Diego Caliari, Barbara Cardazzo, CALIARI, DIEGO, Roberta Rasotto, FRASSINETI, FEDERICA, ZAPPULLI, VALENTINA ELENA GIUDITTA, RASOTTO, ROBERTA, Federica Frassineti, Michael H Goldschmidt   +13 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

An Unusual Presentation of Synchronous Breast Cancer and Skin Malignancy in a Patient with Lynch Syndrome: A Case Report and Review of the Literature

Biomedicines
Background: Lynch syndrome is an autosomal dominant condition that leads to an increased risk of many neoplasms. In the United Kingdom, NICE recommends that patients with colorectal and endometrial cancer should be tested for Lynch syndrome.
Maiar Elghobashy, Michael Siafakas, Mona Elshafie, Rahul Hejmadi, Naren N. Basu, Abeer M. Shaaban   +5 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Triple-Negative Breast Cancer Coexisting with Adenomyoepithelioma: A Case Report

Journal of the Korean Society of Radiology
Adenomyoepithelioma (AME) is a rare breast tumor characterized by the proliferation of both inner epithelial and outer myoepithelial cells. Here, we report a case of AME coexisting with triple-negative breast cancer (TNBC) in a 55-year-old woman ...
Sang Ah Cho, Jin Chung, Ji Min Kim, Sun Hee Sung, Eun Suk Cha, Jeoung Hyun Kim   +5 more
doaj   +1 more source

Sebaceous breast carcinoma

Autopsy and Case Reports, 2022
Breast sebaceous carcinoma is one of the rarest breast neoplasms, with less than 30 cases reported worldwide. Due to the rarity, the new WHO classification of breast tumors grouped these tumors among the ductal carcinoma. A detailed description of these
Natália Nobre de Alencar, Diego Agra de Souza, Alexandre Alves Lourenço, Raimunda Ribeiro da Silva   +3 more
doaj