Results 61 to 70 of about 164,343 (265)
JCO Global Oncology, 2020 Breast cancer accounts for a high burden among all the neoplasms in Latin America, with more-advanced stages at presentation, which could result in high mortality rates.
Henry L. Gomez +5 more
doaj +1 more source
Roles of eIF3m in the tumorigenesis of triple negative breast cancer
Cancer Cell International, 2020 Without targets, triple negative breast cancer (TNBC) has the worst prognosis in all subtypes of breast cancer (BC). Recently, eukaryotic translation initiation factor 3 m (eIF3m) has been declared to be involved in the malignant progression of various ...
W. Han +13 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Journal of the Korean Society of RadiologyA 74-year-old woman was diagnosed with locally advanced invasive ductal carcinoma of the right breast, which was confirmed as triple-negative breast cancer (TNBC) by immunohistochemical analysis. Multiple ipsilateral axillary lymph node metastases were
Seo Ha Park +4 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Pakistan Armed Forces Medical Journal, 2020 Objective: To determine the prevalence of histological subtypes of breast cancer and its association with age, molecular subtype, menopausal status, parity, obesity and tumor grade. Study Design: Prospective, observational study.
Shumyla Beg +7 more
doaj +2 more sources
Use of positron emission tomography-computed tomography to predict axillary metastasis in patients with triple-negative breast cancer [PDF]
Korean Journal of Clinical Oncology, 2018 Purpose Axillary lymph node dissection (ALND) and sentinel lymph node biopsy (SLNB) are important for staging of patients with node-positive breast cancer.
Jung Hyun Youm +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Importance of Nectin2, NUF2, and Nectin4 Gene Expression in the Pathogenesis of Different Subtypes of Breast Cancer [PDF]
Middle East Journal of CancerBackground: The targeted therapy using breast cancer (BC)-associated biomarkers has significantly minimized the side-effects of BC treatment. This study aims to elucidate the role of Nectin2, NUF2, and Nectin4 gene expression in the pathogenesis of BC ...
Zahra Roshanizadeh +6 more
doaj +1 more source