Results 71 to 80 of about 58,367 (308)
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
The Triple Helix in the context of global change: dynamics and challenges
Prometheus, 2014 Understanding how economies change through interactions with science and government as different spheres of activity requires both new conceptual tools and methodologies.
Helen Lawton Smith, Loet Leydesdorff
doaj +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
The Role of Government / Academia / Industry in Building Innovation-Based Cities and Nations, Vol. 1, Triple Helix Best Practices [PDF]
, 2019 Triple Helix Best Practice Series is an annual publication by the Triple Helix Association demonstrating evidence of successful implementation of university-industry-government programs that mobilise multistakeholder coalitions, driving alliances and ...
Alshamsi, Abdullah M. +2 more
core
FEBS Open Bio, EarlyView.The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Value-based Innovation: Knowledge and Technology Transfer in Triple Helix Model
International Journal of Technology, 2016 In light of globalization, innovation has been determined as a strategy to increase competitive advantage, and, therefore, nurturing innovation through improved policies and practices has become a priority in both the public and private sectors ...
Mohammed Ali Berawi
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
The Legacy of Loet Leydesdorff to the Triple Helix as a Theory of Innovation
This paper is an in memoriam tribute to the distinguished scholar Loet Leydesdorff written by some of his academic collaborators, including the editors of the Triple Helix journal and representatives of the Triple Helix Association.
Rapetti, Carina +4 more
core +1 more source
Strategi Penguatan Kinerja Manajemen UKM di Serang Banten
Ekonomi dan Bisnis, 2020 This research is motivated by the decline in sales turnover realization in Serang, Banten, West Java. As a result of intense competition, marketing improvements must be done immediately.
Bernadin Dwi Mardiatmi, Dahlia Pinem
doaj +1 more source