Results 181 to 190 of about 287,154 (333)

Recent Advances in Immunotherapy for Breast Cancer: A Review

Breast Cancer: Targets and Therapy
Qian-Er Wen,1 Liang Li,1 Rui-Qi Feng,1 De-Hui Li,2 Chang Qiao,1 Xiao-Song Xu,3 Yan-Jing Zhang2 1Graduate School, Hebei University of Chinese Medicine, Shijiazhuang, Hebei Province, People’s Republic of China; 2Oncology Department II, The First Affiliated
Wen QE, Li L, Feng RQ, Li DH, Qiao C, Xu XS, Zhang YJ   +6 more
doaj  

64P Comprehensive genomic analysis of primary triple negative breast cancer prior to neoadjuvant chemotherapy [PDF]

, 2020
Monika Drobnienė, Rasa Sabaliauskaitė, Edvardas Žurauskas, Raimundas Meškauskas, Birutė Brasiūnienė, Sonata Jarmalaitė   +5 more
openalex   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, EarlyView.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source

HOXB7 overexpression leads triple-negative breast cancer cells to a less aggressive phenotype [PDF]

, 2021
Simone Aparecida de Bessa Garcia, Mafalda Araújo, Tiago Pereira, Renata Freitas   +3 more
openalex   +1 more source

Efferocytosis‐Driven Polyamine Metabolism in Macrophages Enhances Cancer Stem Cell Enrichment after Chemotherapy in Ovarian Cancer

Advanced Science, EarlyView.
Chemotherapy‐induced efferocytosis drives ovarian cancer stem cell enrichment. By engulfing apoptotic cancer cells, macrophages upregulate ODC1 and produce putrescine, which elevates osteopontin (OPN) expression. Secreted OPN then activates the CD44 receptor on cancer cells, promoting stemness and chemoresistance.
Wenhan Li, Feiquan Ying, Xinkai Pang, Qiulei Wu, Guoqing Li, Lin Huang, Jiayu Xin, Xiaoli Liu, Pan Liu, Xiaohan Xu, Shuran Tan, Yumei Gao, Tong Liu, Si Sun, Xiaoman Wang, Yiping Wen, Liqiong Cai, Shi Du, Yuan Zhang, Jing Cai   +19 more
wiley   +1 more source

A home-based lifestyle intervention program reduces the tumorigenic potential of triple-negative breast cancer cells [PDF]

Giulia Baldelli, Valentina Natalucci, Carlo Ferri Marini, Davide Sisti, Giosuè Annibalini, Roberta Saltarelli, Matteo Bocconcelli, Veronica Gentilini, Rita Emili, Marco Rocchi, Francesco Lucertini, Elena Barbieri, Giorgio Brandi, Mauro De Santi   +13 more
openalex   +1 more source

Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross-links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer

, 2020
Patricia Monteiro, Muhammad Gulfam, Cíntia J. Monteiro, Alessandra Travanut, Thais Fedatto Abelha, Amanda K. Pearce, Christine Jérôme, Anna M. Grabowska, Philip A. Clarke, Hilary M. Collins, David M. Heery, Pavel Gershkovich, Cameron Alexander   +12 more
openalex   +2 more sources

PTG‐Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM2.5 to Metabolic Disorders

Advanced Science, EarlyView.
This study provides the first evidence that PM2.5 impairs iWAT browning via PTG‐mediated glycogen metabolism disruption, which is initiated by ADRB3 inhibition and subsequently triggers VEGFB upregulation. It thereby delineates the ADRB3‐PTG‐VEGFB axis as central to PM2.5‐induced metabolic dysfunction and identifies adipose glycogen metabolism as a ...
Limin Wang, Renjie Hu, Yanxi Chai, Ping He, Sanduo Li, Lisha Zhao, Wenbin Zhao, Lu Zhang, Li Qin, Ran Li, Xiaoli Hou, Qinghua Sun, Cuiqing Liu   +12 more
wiley   +1 more source

Supplementary Table S2 from An Olive Oil–Based High-Fat Diet Promotes Obesity-Driven Metastasis of Triple-Negative Breast Cancer

Anthony M. Avellino, Xingshan Jiang, Michael Lee, Jianyu Yu, Shanshan Liu, Xiaochun Han, Jerry Li, Jonathan Shilyansky, Zhaohua Wang, Melissa Curry, Yiqin Xiong, Ingrid M. Lizarraga, Yi Huang, Sonia L. Sugg, Jiaqing Hao, Bing Li   +15 more
openalex   +1 more source