Results 31 to 40 of about 287,154 (333)

Molecular Classification, Treatment, and Genetic Biomarkers in Triple-Negative Breast Cancer: A Review

Technology in Cancer Research & Treatment, 2023
Breast cancer is the most common malignancy and the second most common cause of cancer-related mortality in women. Triple-negative breast cancers do not express estrogen receptors, progesterone receptors, or human epidermal growth factor receptor 2 and ...
Boya Lu MD, Elango Natarajan PhD, Hanumantha Rao Balaji Raghavendran PhD, Uma Devi Markandan PhD   +3 more
doaj   +1 more source

A molecular approach to triple-negative breast cancer: targeting the Notch signaling pathway [PDF]

Einstein (São Paulo)
Introduction Triple-negative breast cancer is an aggressive subtype of breast cancer characterized by the absence of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression. This phenotype renders triple-negative
Isabele Pardo, Pedro Brecheret Fagundes, Rafael Santana de Oliveira, Paulo Vidal Campregher   +3 more
doaj   +1 more source

Genetic events in the progression of adenoid cystic carcinoma of the breast to high-grade triple-negative breast cancer [PDF]

, 2016
Adenoid cystic carcinoma of the breast is a rare histologic type of triple-negative breast cancer with an indolent clinical behavior, often driven by the MYB-NFIB fusion gene.
Badve, Sunil S., Bamba, Masamichi, Burke, Kathleen A., De Filippo, Maria R., Ellis, Ian O., Fuhrmann, Laetitia, Fusco, Nicola, Geyer, Felipe C., Guerini-Rocco, Elena, Ichihara, Shu, Jungbluth, Achim A., Lim, Raymond S., Martelotto, Luciano G., Moritani, Suzuko, Ng, Charlotte K.Y., Piscuoglio, Salvatore, Reis-Filho, Jorge S., Schultheis, Anne M., Vincent-Salomon, Anne, Wang, Lu, Weigelt, Britta   +20 more
core   +2 more sources

Efficacy and selectivity of tumor-treating field therapy for triple-negative breast cancer cells via in-house delivery device

Discover Oncology, 2023
Purpose Triple-negative breast cancer continues to be one of the leading causes of death in women, making up 7% of all cancer deaths. Tumor-treating electric fields are low-energy, low-frequency oscillating electric fields that induce an anti ...
Austin R. Smothers, Jason R. Henderson, John J. O’Connell, Jonathan M. Stenbeck, Delphine Dean, Tyler G. Harvey, Brian W. Booth   +6 more
doaj   +1 more source

Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion. [PDF]

, 2016
Estrogen receptor (ER)-negative cancers have a poor prognosis, and few targeted therapies are available for their treatment. Our previous analyses have identified potential kinase targets critical for the growth of ER-negative, progesterone receptor (PR)-
Brown, Powel H, Chang, Jenny, Den Hollander, Petra, Fuqua, Suzanne, Hartman, Zachary C, Hill, Jamal, Hilsenbeck, Susan G, Kent Osborne, C, Mazumdar, Abhijit, Mills, Gordon B, Poage, Graham M, Shepherd, Jonathan, Tsimelzon, Anna, Zhang, Yun   +13 more
core   +2 more sources

Modulation of the BRCA1 Protein and Induction of Apoptosis in Triple Negative Breast Cancer Cell Lines by the Polyphenolic Compound Curcumin

Breast Cancer: Basic and Clinical Research, 2009
In the current study, we sought to examine the effects of curcumin in a specific type of breast cancer called triple negative breast cancer. These cancers lack expression of the estrogen and progesterone receptors and do not over-express HER2.
Danica L. Rowe, Tuba Ozbay, Ruth M. O'Regan, Rita Nahta   +3 more
doaj   +2 more sources

Triple-Negative Breast Cancer [PDF]

The American Journal of Pathology, 2017
Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer that differs in epidemiology, risk factors, and prognosis from other types of breast cancer. The challenge in treating TNBC lies in the lack of targeted therapies currently available. Chemotherapy remains the only treatment option presently. Current research efforts are focused
Jonathan D. Marotti, Francine B. de Abreu, Wendy A. Wells, Gregory J. Tsongalis   +3 more
openaire   +2 more sources

FA2H Exhibits Tumor Suppressive Roles on Breast Cancers via Cancer Stemness Control

Frontiers in Oncology, 2019
Background: Triple negative breast cancers are aggressive, enriched with cancer stem cells, and lack effective targeted therapies with little side effects.Methods: We isolated cancer stem cells from two triple negative breast cancer cell lines via cell ...
Xiaofeng Dai, Shuo Zhang, Hongye Cheng, Dongyan Cai, Dongyan Cai, Xiao Chen, Zhaohui Huang, Zhaohui Huang   +7 more
doaj   +1 more source

Triple negative breast cancer: new perspectives for targeted therapies [PDF]

, 2015
Breast cancer is a heterogeneous disease, encompassing a large number of entities showing different morphological features and having clinical behaviors.
Caruso, Davide, Frati, Luigi, Minozzi, Marina, Papa, Anselmo, Rossi, Luigi, Tomao, Federica, Tomao, Silverio, Vici, Patrizia, Zaccarelli, Eleonora   +8 more
core   +1 more source

Radiological diagnostics of triple negative breast cancer: a review

Acta Medica Lituanica, 2011
Background. Triple negative breast cancer has a poor prognosis. Therefore, it is vital to detect this subtype of breast cancer in its early stage. The imaging features of this clinically important subtype of breast cancer are not well known.
Sigutė STADALNYKAITĖ, Rūta BRIEDIENĖ
doaj   +1 more source