Results 61 to 70 of about 287,154 (333)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

New FTY720-docetaxel nanoparticle therapy overcomes FTY720-induced lymphopenia and inhibits metastatic breast tumour growth [PDF]

, 2017
Purpose: Combining molecular therapies with chemotherapy may offer an improved clinical outcome for chemoresistant tumours. Sphingosine-1-phosphate (S1P) receptor antagonist and sphingosine kinase 1 (SK1) inhibitor FTY720 (FTY) has promising anticancer ...
A Jemal, A Panariti, AS Paraskar, AV Korotcov, C White, Colin Cooper, D Pchejetski, D Pchejetski, D Pchejetski, D Pchejetski, D Simberg, Dmitri Pchejetski, E Fröhlich, F Yuan, FJ Esteva, H Alshaker, H Alshaker, H Alshaker, H Alshaker, H Azuma, H Gao, Heba Alshaker, HS Rugo, J Ohotski, JA Cohen, JM Nabholtz, K Adachi, K Maruyama, KJ French, L Kappos, L Sauer, L Treuel, M Noori Koopaei, MJ Ernsting, ML Immordino, N Kamaly, NJ Pyne, NK Ibrahim, P Kallinteri, P Parhi, P Yousefpour, Q Gu, Qi Wang, R Misra, R Rosa, S Basu, S Mitragotri, S Permpongkosol, S Saremi, Shyam Srivats, W Tao, WJ Gradishar, Y Li, Y Mousseau, Y Zong, Yimin Chao, ZH Mirzaie   +56 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Functional proteomics outlines the complexity of breast cancer molecular subtypes [PDF]

, 2017
Breast cancer is a heterogeneous disease comprising a variety of entities with various genetic backgrounds. Estrogen receptor-positive, human epidermal growth factor receptor 2-negative tumors typically have a favorable outcome; however, some patients ...
Arevalillo, J. M., Berges-Soria, J., Ciruelos, E., del Prado, P., Díaz-Almiron, M., Espinosa, E., Feliu, J., Gamez-Pozo, A., Grossmann, J., López-Vacas, R., Main Yaque, Paloma, Moreno, F. G., Nanni,, P., Navarro, H., Prado-Vazquez, G., Rioja, R. G., Selevsek, N., Trilla-Fuentes, L., Vara, J. A.F., Zamora, P., Zapater-Moros, A.   +20 more
core   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

THE ROLE OF TUMOR-INFILTRATING LYMPHOCYTES IN TRIPLE NEGATIVE BREAST CANCER [PDF]

Romanian Journal of Medical Practice, 2018
Triple-negative breast cancer (TNBC), which lacks the expression of hormone receptors and human epidermal growth factor receptor-2 (HER2) represents the breast cancer subtype with the poorest prognosis.
Anca Zgura, Simona Carniciu, Laurentia Gales, Rodica Anghel   +3 more
doaj   +1 more source

Association of Vitamin D3 Level with Breast Cancer Risk and Prognosis in African-American and Hispanic Women. [PDF]

, 2017
Background: This study investigated the association of vitamin D3 levels with breast cancer risk and progression in African-Americans and Hispanics. Methods: A total of 237 African-American (Cases = 119, Control = 118) and 423 Hispanic women (Cases = 124,
Chlebowski, Rowan, Clayton, Sheilah, Sarkissyan, Marianna, Vadgama, Jaydutt V, Wu, Yanyuan   +4 more
core   +2 more sources

Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer [PDF]

, 2021
Honglin Yan, Bin Luo, Xiaoyan Wu, Feng Guan, Xinxin Yu, Lina Zhao, Xiaokang Ke, Juan Wu, Jingping Yuan   +8 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

A clinicopathologic study on triple-negative breast cancer patients: HUSM experience [PDF]

, 2011
Breast cancer is the most common cancer among Malaysian women. There are many prognostic factors contributing to the disease and the outcome of the patients.
Saidin, Usman Sani
core