Results 71 to 80 of about 6,967,236 (252)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD) Sejung Lee, Junghyeok Lim, Jinhyuk Bhinwiley +1 more sourceCommon variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. [PDF]
, 2012 Several common alleles have been shown to be associated with breast and/or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Recent genome-wide association studies of breast cancer have identified eight additional breast cancer susceptibility ...Dutra-Clarke, Ana, CIMBA, SWE-BRCA, Bruno Buecher, Theo A. Van Os, Dorfling, Cecelia M., Beesley, Jonathan, Donaldson, A., Mark H Greene, Verhoef, Senno, Tihomirova, L, Pankratz, Vernon, Engel, C., Muy-Kheng Tea, Barrowdale, D., Douglas, F., Maria A Caligo, Lespérance, B, Anne Marie Gerdes, Barkardottir, Rosa B, Varon-Mateeva, Raymonda, Ozcelik, Hilmi, Kast, K, Raymonda Varon Mateeva, Hurteau, J., Meindl, A., Heli Nevanlinna, Diez, O., Patricia A. Ganz, Harbst, K, Jennifer T Loud, de la Hoya, Miguel, Odunsi, K, Andrew K. Godwin, Jan C. Oosterwijk, Dorfling, Cecelia, Skytte, Anne-Bine, Zlowowcka-Perlowska, Elzbieta, Paolo Peterlongo, Bonanni, Bernardo, Ana Osorio, John L Hopper, Walker, L, Arnold, N, Morrison, Patrick, Hopper, JL, Yuan C. Ding, Arver, Brita, Ausems, Margreet, Brita Arver, Niederacher, D, Lubinski, Jan, Tihomirova, L., Kuchenbaecker, Karoline B, Ana Dutra Clarke, Gómez Garcia, Encarna B., Douglas F. Easton, Brewer, C., Mulligan, A.M., Osorio, A, Antonis C. Antoniou, Simone Heidemann, Esther M John, Mazoyer, S, Calender, A, Blanco, I, Rosa B. Barkardottir, Patrick J Morrison, Lee, A, Papi, Laura, GEMO Collaborators Study, Beattie, M.S., Lindblom, A., van Os, Theo A, van Rensburg, Elizabeth Jansen, van Os, Theo, Platte, Radka, Mieke Kriege, Spurdle, Amanda B, Antoniou, Antonis, Kirk, J, Ganz, Patricia A, Greene, Mark H., Ferrer, Sandra F, Gross, Jenny, Susan L Neuhausen, Yuan C Ding, Os, T.A., Mortemousque, Isabelle, Kirk, Judy, Ignacio Blanco, Hansen, T.V., Donaldson, A, Fredericksen, Z, Eeles, R., Hopper, J.L., Andrea Gehrig, Taru A Muranen, Godwin, AK, Nathanson, K, Buys, S., Peterlongo, Paolo, Kwong, A., Varon-Mateeva, R, Calender, A., Kruse, Torben A, Ros Eeles, Muy-Kheng, Tea, Terry, Mary, Kuchenbaecker, K. B., Montagna, M., Fiorica, J, Kruse, Torben A., Noralane M. Lindor, Gadzicki, D., Lindor, Noralane M, Loud, Jennifer, Pankratz, Vernon S, Davidson, R., Soucy, Penny, Raymonda Varon-Mateeva, D. E. Antoine Pauw, Brewer, Carole, Study Gemo Collaborators, Kruse, T.A., Judy Kirk, Sue Healey, Gerdes, Anne-Marie, Singer, Christian, Radka Platte, Engel, Christoph, Taru A. Muranen, Lindblom, Annika, Annika Lindblom, Torben A. Kruse, Ligtenberg, Marjolijn J., Schäfer, Dieter, Muranen, Taru, Xiaoqing Chen, Verhoef, S, Kirchhoff, T., Prieur, Fabienne, Hansen, Thomas V., Morrison, Patrick J., Godwin, Andrew K, Christian Sutter, Meindl, A, D. Geschwantler Kaulich, Muy Kheng Tea, Karlan, B.Y., Toland, Amanda E, Gómez Garcia, EB, Dieter Niederacher, Collée, J. Margriet, Wijnen, J., Ottini, Laura, Gross, J, Orland Diez, Os, T.A. van, Evans, Gareth; id_orcid, Isaacs, Claudine, Peterlongo, P, Jaworska, K., Fredericksen, Z., Jaworska, Katarzyna, Wijnen, J, Loman, Niklas,, Ozcelik, H, Rosa B Barkardottir, Manoukian, S., Rogers, Mark, Daniel Barrowdale, Gaudet, M., Hogervorst, Frans B, Adlard, J, Easton, Douglas F., Léoné, Mélanie, van Os , Theo, Fineberg, E, Byron, John, Collee, Margriet, Bernard Peissel, SWE-BRCA Study Collaborator, Caligo, MA, Lazaro, C, Muranen, TA, Ausems, M.G., Hanne EJ Meijers-Heijboer, Wang, X.S., Ferrer, S.F., Hogervorst, F.B., Domchek, S., Schmutzler, RK, Gomez Garcia, E.B., Anne Bine Skytte, Frenay, M, Lubinski, J., Kuchenbaecker, KB, Maria A. Caligo, Sutter, C., Anne-Marie Gerdes, Helmut Deissler, Finn C Nielsen, Garcia, E.B.G., Beattie, Mary S., Caligo, Maria A, Toland, Amanda E., Penny Soucy, Mulligan, Anna Marie, Mads Thomassen, Spurdle, Amanda, EMBRACE Study Collaborator, Dolcetti, Riccardo, Mazoyer, S., Deissler, H., Eeles, Ros, Gayther, Simon A, Tea, Muy-Kheng, Marjolijn J. Ligtenberg, van Os , Theo A, Gadzicki, D, Ferrer, Sandra, Sobol, H., Lesperance, B., Kirchhoff, T, Gayther, SA, Fergus J Couch, A. De Pauw, Cristina Oliani, Hansen, TV, Lespérance, Bernard, Frost, D., Vernon S Pankratz, Terry, MB, Hansen, Thomas V, Neuhausen, Susan, Hopper, John L., Hansen, TVO, van Os, TA, Hamann, U, Conxi Lazaro, Antoniou, AC, Rosemarie Davidson, Imyanitov, E., Dorfling, C.M., Isaacs, C., Davidson, R, Teulé, A, Hansen, T.V.O., Donaldson, Alan, Kaulich, Daphne, J Margriet Collée, Kaulich, Daphne, Geschwantler, Domchek, S, Mary S Beattie, Collée, JM, Offit, K, Adlard, Julian, John M. Esther, Frost, D, Cook, J., Schaefer, Dieter, Wang, XS, Ottini, L, Wang, Xianshu, Caligo, Maria, Peock, Susan, Karlan, BY, Elizabeth Jansen van Rensburg, Terry, MU, Jakubowska, Anna, Papi, L., Lee, A., Nielsen, FC, Paillerets, B. Bressac-de, John, EM, Embrace Hebon, Mulligan, AM, Kriege, M, Muranen, Taru A., Gayther, Simon, Teo, S.H., Mulligan, AU, Meijers-Heijboer, HE, Dieter Schafer, Rita K. Schmutzler, Wang, X, Sutter, C, Susan Domchek, Piedmonte, Marion, Ganz, P.A., Lalloo, F., Bove, Betsy, Alan Donaldson, E. Jansen Van Rensburg, Evans, D G, Kriege, Mieke, Ferrer, Sandra U., Schafer, D., Durda, K., Adlard, J., Loris Bernard, Encarna B. Gomez Garcia, Hamann, Ute, Miguel De La Hoya, Singer, Christian F, Norbert Arnold, Ausems, MG, Easton, Douglas, McGuffog, L., Peissel, Bernard, Tomas Kirchhoff, Blanco, I., Buys, S, Nathanson, Kate, Miron, A., Collee, M, Ganz, PA, Frost, Debra, Radice, Paolo, Arnold, Norbert, Rebbeck, T, Kast, Karin, Lubinski, J, Barkardottir, Rosa, Caldes, T., Frans B Hogervorst, Alexander Miron, Sinilnikova, OM, Meijers-Heijboer, Hanne E, Lisa Walker, Frans B. Hogervorst, Rosenquist, Richard,, Riccardo Dolcetti, Valle, J. Del, Chris Jacobs, Fiorica, J., Ozcelik, H., Trinidad Caldes, Stoppa-Lyonnet, D., Léoné, M, Ferrer, Sandra,, K. Investigators, Dorkins, H, Cohn, David, Kuchenbaecker, K.B., Wijnen, J. van, van Os, Theo A., Hansen, Thomas VO, Katarzyna Durda, Morrison, PJ, Wijnen, Juul, David Cohn, Andrés, Raquel, Valle, J Del, Marc Frenay, Karin Kast, Huw Dorkins, Caldes, T, Oosterwijk, Jan, Heidemann, Simone, Hogervorst, FB, Margreet Gem Ausems, Stoppa-Lyonnet, D, Ligtenberg, M.J., Peterlongo, P., Garcia, Encarna B. Gomez, John, Esther, Greene, Mark H, Daphne Kaulich, Teule, A., Olah, E., Gehrig, Andrea, Montagna, M, Ligtenberg, Marjolijn, Beattie, Mary, Anneliese Fink-Retter, Beattie, MS, Vijai Joseph, Kaulich, DG, Kaulich, DU, E. Study, Jackie Cook, Mulligan, Anna, Marie, Encarna B Gómez Garcia, Neuhausen, Susan L, Terry, Mary, Beth, Karlsson, P., Lee, Andrew Roger, Barbara Wappenschmidt, Meindl, Alfons, Terry, Mary,, Neuhausen, S.L., Del Valle, J, van Os, T.A., Lazaro, Conxi, Olah, E, Durda, Katarzyna, Alain Calender, Evgeny Imyanitov, Anna Marie Mulligan, Soucy, P., E. Zlowocka Perlowska, Toland, Amanda, Złowowcka-Perłowska, Elżbieta, Isabelle Mortemousque, Durda, K, Dorkins, Huw, Healey, S, Chen, Xiaoqing, Couch, Fergus, Rosenquist, Richard, Research H. Facility, EMBRACE, Dorothea Gadzicki, Preisler-Adams, S., Glendon, Gord, Karoline B. Kuchenbaecker, Toland, A.E., Karlan, Beth, Greene, M.H., Kaulich, Daphne U., Nevanlinna, H., Hoya, M. de la, Elżbieta Złowowcka-Perłowska, McGuffog, Lesley, Lazaro, C (Conxi), Hilmi Ozcelik, Karoline B Kuchenbaecker, Melanie Leone, Złowowcka-Perłowska, E, Ana Dutra-Clarke, Muranen, Taru A, Lee, Andrew, Jensen, UB, Houdayer, Claude, Raquel Andres, Meijers-Heijboer, H.E., Mazoyer, Sylvie, Christian F. Singer, Olga M Sinilnikova, Hopper, John, Schmutzler, Rita, Platte, R, Antoniou, A.C., Claudine Isaacs, Ellis, Steve D, Terry, Mary U, Singer, CF, Ding, Yuan C., Blanco, Ignacio, Mulligan, Anna,, Oosterwijk, JC, Zlowowcka-Perłowska, Elżbieta, Andrulis, IL, HEBON Study Collaborator, Pankratz, VS, Lesley Mcguffog, Loud, J.T., Chen, XQ, Goldgar, D., Collée, J M, Ausems, Margreet GEM, Ava Kwong, Byron, J., Siranoush Manoukian, Nevanlinna, H, Terry, Mary B, Marjolijn J Ligtenberg, Goldgar, D, Mark H. Greene, Sylvie Mazoyer, Fink-Retter, A., Meijers-Heijboer, Hanne E J, Hanne E. J. Meijers Heijboer, Dorfling, CM, Loman, N., Zaffaroni, Daniela, Preisler-Adams, Sabine, Pankratz, V.S., Chen, X., Heidemann, S, Simard, J., Sobol, Hagay, Easton, D.F., Kwong, A, Sabine Preisler-Adams, Per Karlsson, Fiorica, James, Bernard, L, Godwin, Andrew K., Mary Beth Terry, Radice, P, Niklas Loman, Chenevix-Trench, G., Daly, Mary, V. Joseph, Ausems, MGEM, Sinilnikova, O.M., Terry, Mary Beth, Glendon, G, Ding, Y.C., Ausems, Margreet G. E. M., Elzbieta Złowowcka Perłowska, Muranen, T.A., Hansen, Thomas V. O., Lazaro, C., kConFab Investigators, Buecher, B, Imyanitov, E, Joseph, Vijai, Christoph Engel, van Rensburg, Elizabeth, Jansen, Loud, Jennifer T., Bernard, Loris, Betsy Bove, Ausems, M.G.E.M., Couch, Fergus J, Paterson, J., Garcia, EBG, van Rensburg, EU, Andrulis, Irene L, Barkardottir, Rosa B., Buecher, B., Ganz, Patricia, Olga M. Sinilnikova, Wappenschmidt, B, Zachary Fredericksen, Elena Fineberg, Niederacher, D., Simon A. Gayther, Douglas, F, Hurteau, J, Mia Gaudet, Kunle Odunsi, Cancer Study S. B. Swedish Breast, Carole Brewer, de Pauw, Antoine, Greene, MH, Karlan, Beth Y, Piedmonte, M, Laima Tihomirova, van Rensburg, EJ, Georgia Chenevix-Trench, Osorio, Ana, Bressac-de Paillerets, B., Offit, Kenneth, Nielsen, Finn, van Rensburg, Elizabeth,, Debra Frost, Piedmonte, M., et al., Mercedes Duran, Buecher, Bruno, Jensen, Uffe B, Southey, Melissa, Houdayer, C., Barrowdale, D, Jaworska, K, Spurdle, Amanda B., Kast, K., Nielsen, Finn C, Evans, D Gareth, Bonanni, B, Spurdle, AB, Ligtenberg, Marjolijn J, Greene, Mark, Soucy, P, Southey, M, Hagay Sobol, Evans, DG, Bove, B, Prieur, F, Rebbeck, Tim, Melissa Southey, Cecelia M Dorfling, Nina Ditsch, Frenay, M., Neuhausen, Susan L., Miron, A, Platte, R., Bove, B., Fink-Retter, Anneliese, Fiebig, B, Byron, J, Hodgson, Shirley, Schaefer, D, Jean Hurteau, Shirley Hodgson, Kate Nathanson, de Pauw, A, Oliani, C, Fineberg, E., Antoniou, Antonis C, Kaulich, Daphne,, Trevor Cole, Rogers, M.T., Gayther, Simon A., Paterson, Joan, Andrew K Godwin, Amanda E. Toland, Britta Fiebig, Zaffaroni, D., Joan Paterson, Ditsch, N, Oosterwijk, Jan C., Andres, R., Joseph, V, Fiebig, Britta, Bressac- de Paillerets, Brigitte, Thomassen, Mads, Meijers-Heijboer, HEJ, Soo-Hwang Teo, GEMO Study Collaborator, Prieur, F., Kruse, TA, Tihomirova, Laima, Preisler-Adams, S, Richard Rosenquist, Ferrer, Sandra, Fert, Daphne Geschwantler Kaulich, Rebbeck, T., Leone, M., Ellis, Steve, Thomas V. O. Hansen, Kenneth Offit, Jan Lubinski, Evans, D. Gareth, John Byron, Noralane M Lindor, Walker, Lisa, Marion Piedmonte, Ellis, Steve D., Jonathan Beesley, Caron, O., Heidemann, S., Diez, O, Ditsch, N., Easton, Douglas F, Jacobs, C, Steve D. Ellis, Hogervorst, Frans B., Theo A van Os, Christian F Singer, Morrison, P.J., Niederacher, Dieter, Chenevix-Trench, G, Teo, Soo-Hwang, Mary S. Beattie, Arver, B., Cohn, D., Mark T Rogers, Del Valle, J., Jensen, Uffe B., Lund University., Dolcetti, R, van Wijnen, J (Juul), Gehrig, A, Teulé, Alex, D. Gareth Evans, Dominique Stoppa Lyonnet, Oosterwijk, J.C., Pankratz, Vernon S., Geschwantler Kaulich, Daphne, Couch, FJ, Offit, K., Evans, D.G., Jensen, Uffe, Meijers-Heijboer, Hanne EJ, Eeles, R, Nevanlinna, Heli, Schäfer, D, Cook, Jackie, Ditsch, Nina, Healey, S., John L. Hopper, Jacques Simard, Ligtenberg, MJ, Hodgson, S., Benítez, J, van Rensburg, Elizabeth U., Engel, C, van Rensburg, Elizabeth J, Gehrig, A., Durán, M, Meijers-Heijboer, Hanne, Peissel, B., Simard, Jacques, Jakubowska, A, Hogervorst, Frans, Gayther, S.A., Glendon, G., Uffe B. Jensen, Caron, O (Olivier), J. Del Valle, Ding, Yuan, Beesley, J, Odunsi, Kunle, Terry, Mary U., Odunsi, K., Jacobs, Chris, Valle, J D, van Rensburg, Elizabeth U, Sabine Preisler Adams, Amanda E Toland, Cecelia M. Dorfling, Terry, M.U., Diez, Orland, Couch, Fergus J., Mulligan, Anna U., Benítez, Javier, Lindor, N.M., Sandra Ferrer, Sandra Fert Ferrer, Mulligan, Anna M, Joseph Vijai, Dutra-Clarke, A., Douglas, Fiona, Beattie, Mary S, Mulligan, Anna U, Couch, F.J., Loud, Jennifer T, Paterson, J, Thomas VO Hansen, Daly, M., Jenny Gross, Chen, X, Ellis, S.D., Montagna, Marco, Hamann, U., Patrick J. Morrison, Teo, SH, Ding, Yuan C, Steve D Ellis, Toland, AE, Douglas F Easton, Ferrer, Sandra Fert, Ausems, Margreet G E M, Saundra Buys, Fabienne Prieur, Kriege, M., Gómez Garcia, Encarna B, Irene L Andrulis, Mulligan, Anna, Karlan, Beth Y., A. Van, Laura Ottini, Kwong, Ava, Torben A Kruse, Manoukian, S, Laura Papi, Spurdle, A.B., Collée, J Margriet, Gross, J., Benitez, J., Caligo, Maria A., Andrulis, Irene, Gaudet, M, Neuhausen, SL, Simard, J, Andrés, R, Skytte, AB, James Fiorica, Kuchenbaecker, Karoline, Isaacs, C, Mortemousque, I, Mary Terry, Hurteau, Jean, Kruse, Torben, Ding, YC, Fiona Douglas, Brewer, C, null null, Mortemousque, I., Olah, Edith, Zlowowcka-Perlowska, E., Bressac-de Paillerets, B, Lindor, NM, John Em, CIMBA Study Collaborator, Sinilnikova, Olga M, Caron, Olivier, Andrulis, Irene L., Arnold, N., Gerdes, A-M, Thomassen, M, Soo Hwang Teo, Kuchenbaecker, Karoline B., Harbst, K., Juul Wijnen, Uffe B Jensen, Davidson, Rosemarie, Tea, M-K, David Goldgar, Bernardo Bonanni, Sinilnikova, Olga Muno, Hansen, Thomas, Jennifer T. Loud, Ganz, Patricia A., John, E.M., van Rensburg, Elizabeth, Easton, DF, Fiebig, B., Dorfling, Cecelia M, Harbst, Katja, Terry, M.B., Piedmonte, M., Gaudet, Mia, Ottini, L., Teo, S-H, Duran, M., Susan Peock, Kaulich, Daphne G, Barkardottir, RB, Zlowowcka-Perlowska, E, Nathanson, K., Singer, C.F., Simon A Gayther, Dolcetti, R., Kaulich, Daphne U, Senno Verhoef, John, Esther M., Chenevix-Trench, Georgia, Elizabeth Van Rensburg, J Del Valle, Papi, L, Skytte, A-B, Kaulich, D.G., Fink-Retter, A, Lalloo, Fiona, Godwin, A.K., Alex Teule, Ute Hamann, Lindor, Noralane, Marco Montagna, Valle, JD, Pauw, A. de, John, Esther M, Antoniou, Antonis C., Verhoef, S., Katarzyna Jaworska, Varon-Mateeva, R., Barrowdale, Daniel, Andrulis, I.L., Caligo, M.A., Oliani, C., Swe Brca Cimba, Sutter, Christian, Meijers-Heijboer, Hanne EJ., Rosenquist, R., Karlsson, P, D Gareth Evans, Frenay, Marc, Anna Mulligan, Claude Houdayer, Schmutzler, R.K., Anneliese Fink Retter, Brigitte Bressac De Paillerets, Cook, J.L., Cole, T., Lalloo, F, Anna Jakubowska, Bressac-de Paillerets, Brigitte, Fiona Lalloo, Jacobs, C., Katja Harbst, Karlsson, Per W., Cohn, D, Joseph, V., Collee, J.M., Sinilnikova, Olga M., Bonanni, B., de Pauw, A., Fineberg, Elena, Amanda B. Spurdle, Healey, Sue, Daly, M, Antoniou, A. C., Chen, X.Q., Rita K Schmutzler, Rogers, MT, Patricia A Ganz, Beesley, J., Calender, Alain, Finn C. Nielsen, Skytte, A.B., Gadzicki, Dorothea, Loman, N, Cook, J, Wappenschmidt, B., Beth Y. Karlan, Dorkins, H., Kaulich, D.U., Mary Daly, Hopper, John L, Domchek, Susan, Lindblom, A, Tim Rebbeck, Vernon S. Pankratz, Godwin, Andrew, Oosterwijk, Jan C, de la Hoya, M, Nielsen, F.C., Meijers-Heijboer, Hanne E. J., Thomassen, M., Deissler, Helmut, Kirchhoff, Tomas, Barkardottir, R.B., Rogers, Mark T., Daniela Zaffaroni, Harbst, Katja,, Paolo Radice, Gómez Garcia, Encarna, Buys, Saundra, Ligtenberg, M.J.L., Morrison, Patrick J, J. Margriet Collee, Jan C Oosterwijk, Ausems, Margreet G, Tea, MK, Peterlongo, Paulo, Miron, Alexander, Fergus J. Couch, Schmutzler, Rita K., Ferrer, Sandra U, Terry Mu, Singer, Christian F., Peock, S., Irene L. Andrulis, Georgia Chenevix Trench, Tea, M.K., Bernard, L., Terry Mb, Houdayer, C, Durán, Mercedes, Southey, M., Peock, S, Goldgar, David, Zaffaroni, D, Hodgson, S, Cole, Trevor, Imyanitov, Evgeny, Nielsen, Finn C., Rensburg, E.J. van, Jensen, U.B., Ferrer, SF, Jansen van Rensburg, Elizabeth, Bernard Lesperance, Gerdes, A.M., Oliani, Cristina, Arver, B, Deissler, H, HEBON, Ellis, SD, Karlsson, Per, Julian Adlard, Beth Y Karlan, Manoukian, Siranoush, Meijers-Heijboer, H.E.J., Javier Benitez, Osorio, A., Collee, M., Radice, P., Alfons Meindl, Andrew Lee, Mark T. Rogers, Kirk, J., Jakubowska, A., Gerdes, AM, Schmutzler, Rita K, Wappenschmidt, Barbara, Ferrer, SU, Thomassen, Marga, Rogers, Mark T, Caldes, Trinidad, Amanda B Spurdle, Lindor, Noralane M., Sinilnikova, Olga, Gord Glendon, Study G. Collaborators, Peissel, B, Dutra-Clarke, A, Edith Olah, McGuffog, L, Kaulich, Daphne Geschwantler, Loud, JT, Xianshu Wang, Brigitte Bressac- de Paillerets, Anne-Bine Skytte, Ferrer, S.U., Antonis C Antoniou, Rosenquist, R, Caron, O, Loman, Niklas, Sobol, H, Cole, T, Olivier Caron, Antoine de Pauw, Fredericksen, Zachary, Dominique Stoppa-Lyonnet, Meijers-Heijboer, E.J., Susan L. Neuhausen +999 morecore +4 more sourcesA chromatin-informed transcriptional regulatory framework to stratify patients and guide therapy selection in triple-negative breast cancer
Nature CommunicationsTriple-negative breast cancer is an aggressive and heterogeneous breast cancer subtype with few effective targeted therapies and frequent resistance to chemotherapy.Shalini Bahl, Nergiz Dogan-Artun, Julia Nguyen, Hassan Mahmoud, Wail Ba-alawi, Seyed Ali Madani Tonekaboni, Komaldeep Kaur Kang, Meghan McGuire, Chantal Tobin, Jennifer Silvester, Paul Savage, Lucie Cressot, Ankita Nand, Guanqiao Feng, Paul Guilhamon, Arvind Singh Mer, Christopher Arlidge, Mitchell J. Elliott, Morag Park, David W. Cescon, Benjamin Haibe-Kains, Mathieu Lupien +21 moredoaj +1 more sourceCEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth +3 morewiley +1 more sourcePharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller +16 morewiley +1 more source
