Results 31 to 40 of about 22,597 (261)

Spectral properties of singular Sturm–Liouville operators via boundary triples and perturbation theory

Journal of Differential Equations, 2023
27 ...
Dale Frymark, Constanze Liaw
openaire   +2 more sources

Modeling Heterogeneity of Triple‐Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance

Advanced Science, 2021
Triple‐negative breast cancer (TNBC) is a highly aggressive breast cancer subtype characterized by a remarkable molecular heterogeneity. Currently, there are no effective druggable targets and advanced preclinical models of the human disease.
Fabienne Lamballe, Fahmida Ahmad, Yaron Vinik, Olivier Castellanet, Fabrice Daian, Anna‐Katharina Müller, Ulrike A. Köhler, Anne‐Laure Bailly, Emmanuelle Josselin, Rémy Castellano, Christelle Cayrou, Emmanuelle Charafe‐Jauffret, Gordon B. Mills, Vincent Géli, Jean‐Paul Borg, Sima Lev, Flavio Maina   +16 more
doaj   +1 more source

Grid Strength Assessment for Inhomogeneous Multi-infeed HVDC Systems via Generalized Short Circuit Ratio

Journal of Modern Power Systems and Clean Energy, 2023
Generalized short circuit ratio (gSCR) for grid strength assessment of multi-infeed high-voltage direct current (MIDC) systems is a rigorous theoretical extension of the traditional SCR, which enables SCR to be extended to MIDC systems.
Guanzhong Wang, Huanhai Xin, Di Wu, Zhiyi Li, Ping Ju   +4 more
doaj   +1 more source

Triple parton scattering in collinear approximation of perturbative QCD [PDF]

Physical Review D, 2016
10 pages, considerably extended version, accepted for publication in Phys.
openaire   +2 more sources

Proposal for a cavity-induced measurement of the exchange coupling in quantum dots

Physical Review Research, 2022
In spin qubit arrays the exchange coupling can be harnessed to implement two-qubit gates and to realize intermediate-range qubit connectivity along a spin bus.
Florian Ginzel, Guido Burkard
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Pressure Transient Analysis and Flux Distribution for Multistage Fractured Horizontal Wells in Triple-Porosity Reservoir Media with Consideration of Stress-Sensitivity Effect

Journal of Chemistry, 2015
Triple-porosity model is usually adopted to describe reservoirs with multiscaled pore spaces, including matrix pores, natural fractures, and vugs.
Jingjing Guo, Haitao Wang, Liehui Zhang, Chengyong Li   +3 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Computational drug repositioning for the identification of new agents to sensitize drug-resistant breast tumors across treatments and receptor subtypes

Frontiers in Oncology, 2023
IntroductionDrug resistance is a major obstacle in cancer treatment and can involve a variety of different factors. Identifying effective therapies for drug resistant tumors is integral for improving patient outcomes.MethodsIn this study, we applied a ...
Katharine Yu, Amrita Basu, Christina Yau, Denise M. Wolf, Hani Goodarzi, Sourav Bandyopadhyay, James E. Korkola, Gillian L. Hirst, Smita Asare, Smita Asare, Angela DeMichele, Nola Hylton, Douglas Yee, Laura Esserman, Laura van ‘t Veer, Marina Sirota, Marina Sirota   +16 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source