Results 71 to 80 of about 216,465 (259)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Mixed-frequency Cascaded H-bridge SVG Ripple Suppression Method

Journal of Harbin University of Science and Technology
To address the DC-side inter-phase voltage imbalance in star-configured cascaded H-bridge static var generator (SVG) under grid unbalanced faults in new power systems, a ripple suppression method combining a hybrid-frequency topology with triple ...
MAI Yunfeng, ZHU Zhenman, RONG Yijun, JI Zhendong   +3 more
doaj   +1 more source

Amino acids 149 and 294 of human lecithin:cholesterol acyltransferase affect fatty acyl specificity

Journal of Lipid Research, 2004
We identified two regions of human LCAT (hLCAT) that when mutated separately to the corresponding rat sequence (E149A and Y292H/W294F) and transiently expressed in COS-1 cells increased phospholipase A2 (PLA2) activity by 5.5- and 2.8-fold, respectively,
Yue Zhao, Abraham K. Gebre, John S. Parks   +2 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Tauberian theorems for (N̄, p, q, w) summable triple sequences of fuzzy numbers

CQD Revista Eletrônica Paulista de Matemática
In this paper, we introduce the notion of weighted mean method (N̄, p, q, w) of triple sequences of fuzzy numbers and and show necessary and sufficient Tauberian conditions under which convergence in Pringsheim's sense of a triple sequence of fuzzy ...
Carlos Bernal Granados, Ajoy Kanti Das, Suman Das   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Knowledge triple extraction in cybersecurity with adversarial active learning

Tongxin xuebao, 2020
Aiming at the problem that using pipeline methods for extracting cybersecurity knowledge triples may cause the errors propagation of entity recognition and did not consider the correlation between entity recognition and relation extraction,and training ...
Tao LI, Yuanbo GUO, Ankang JU
doaj   +2 more sources

Critical response of a single-degree-of-freedom system with bilinear hysteresis and viscous damping under triple impulse

Frontiers in Built Environment
A triple impulse is used as a mathematical model of forward-directivity inputs, which are fault-normal components of near-fault earthquake ground motions. In this paper, two types of the triple impulse input are employed.
Kotaro Kojima, Izuru Takewaki
doaj   +1 more source

Ascent Sequences Avoiding a Triple of Length-3 Patterns

The Electronic Journal of Combinatorics
An ascent sequence is a sequence $a_1a_2\cdots a_n$ consisting of non-negative integers satisfying $a_1=0$ and for $1<i\leq n$, $a_i\leq \text{asc}(a_1a_2\cdots a_{i-1})+1$, where $\text{asc}(a_1a_2\cdots a_k)$ is the number of ascents in the sequence $a_1a_2\cdots a_k$.
David Callan, Toufik Mansour
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source