Results 61 to 70 of about 216,465 (259)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Unresolved triple systems in the aged open cluster Trumpler 19: Discovery, confirmation, and implications★

Astronomy & Astrophysics
Context. It is difficult to identify unresolved triple and higher-order systems beyond the solar vicinity. Star clusters yield controlled environments with known physical parameters, providing a way to explore homogeneous stellar samples. Aims. Combining
Minniti D., Saito R. K., Ivanov V. D., Obasi C. O., Gómez M., Lucas P. W., Fernández-Trincado J. G., Alonso-García J., Garro E. R., Corral-Santana J., Luna A., Guo Z., Kurtev R., Borissova J., Fermiano V., Osses J., Morris C., Dias B., Cáceres C., Saroon S., Pullen J. B., Rodriguez P., Lad M., Federle S., Petralia I., Bhadrakumar D., Esteves P., Navarro M. G., Palma T., Baravalle L., Galdeano D., Alonso M. V., Nilo Castellon J. L., Chené A. N.   +33 more
doaj   +1 more source

A Study of Triple Sequence Spaces

We have great pleasure in presenting this text book of mathematics. This book is intended primarily for students of science and engineering. Its aims are, first, to present the fundamental mathematical ideas which underlie the notion of a convergent sequences, and secondly to develop, as far as the small spaces allows, a body of technique and a ...
Khan, Vakeel A., Esi, Ayhan, Subramanian, Nagarajan, Fatima, Hira   +3 more
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Triple Sequence Learning for Cross-domain Recommendation

ACM Transactions on Information Systems
Cross-domain recommendation (CDR) aims at leveraging the correlation of users’ behaviors in both the source and target domains to improve the user preference modeling in the target domain. Conventional CDR methods typically explore the dual-relations between the source and target domains’ behaviors.
Haokai Ma, Ruobing Xie, Lei Meng 0001, Xin Chen 0091, Xu Zhang 0028, Leyu Lin, Jie Zhou 0016   +6 more
openaire   +4 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source