Results 111 to 120 of about 1,370,973 (287)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

An Extended Kannan Contraction Mapping and Applications [PDF]

open access: yesInternational Journal of Mathematical, Engineering and Management Sciences
We extend the Kannan contraction principle and obtain a result that holds for both contractive and non-expansive mappings. Such mappings admit multiple fixed-points and the fixed-point sets and domains of these mappings display interesting algebraic ...
R. P. Pant
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Triple sequences and their statistical convergence

open access: yes, 2006
Pringsheim gave the definition of the convergence for double sequences in 1900. The idea of statistical convergence was first presented by Fast in 1951. In 2003 Tripathy and Mursaleen et.al introduced statistical convergence of double sequences. In this article we introduce the notions of triple sequences and statistically convergent triple sequence ...
FATMA KADRİYE, DÜDEN   +2 more
openaire   +2 more sources

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

On Triple sequence space of Bernstein operator of Rough I- convergence pre-cauchy sequences

open access: yes
We introduce and study some basic properties of rough I- convergentpre-Cauchy sequences of triple sequence of Bernstein polynomials and also study the set of all rough I- limits of a pre-Cauchy sequence of triple sequence of Bernstein polynomials and ...
Esi, Ayhan, Subramanian, N., Esi, Ayten
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Statistical convergence of triple sequences in topological groups

open access: yes, 2013
The idea of triple statistical convergence was introduced by Sahiner et.al [3] while the idea of double statistical sequences was introduced by Mursaleen and Edely [4]. In this paper, we give an extension of statistical convergence of triple sequences in
Esi, Ayhan
core  

Enticing Sequences of Polynomial Diophantine Triple

open access: yesBODHI International Journal of Research in Humanities, Arts and Science
This paper examines the establishment of an infinite sequences of polynomial Diophantine triples and substantiates that these sequences comprising of triplets is regular and cannot be extended into a quadruple. The findings are derived from the Diophantine pair formed by Vieta polynomials, specifically the Vieta-Pell and Vieta-Pell-Lucas polynomial ...
null G. Janaki, null R. Sarulatha
openaire   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

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