Results 91 to 100 of about 151,657 (257)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Symbolic Dynamics, Mixing and Entropy in the Three-Body Problem

Open Astronomy, 2016
We use symbolic dynamics in the classic equal-mass free-fall three-body problem. Different methods for constructing symbolic sequences (in the process of numerical integration of trajectories) allow one to demonstrate (and illustrate on the Agekian ...
Mylläri A., Orlov V., Chernin A., Martynova A., Mylläri T.   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

De Novo Design of Specific Heterotrimeric Collagen‐Like Peptides via Genetic Algorithm

Advanced Science
Collagen, the most abundant protein by mass in mammals, features a triple‐helical structure composed of three intertwined peptide strands. Nonequivalent strands can assemble, forming heterotrimeric structures, which are more prevalent among natural ...
Thi H. Bui, Oluwakamisi Adetunji, Carson C. Cole, Le Tracy Yu, Caroline M. Peterson, Jeffrey D. Hartgerink   +5 more
doaj   +1 more source

On generation and properties of triple sequence-induced frames in Hilbert spaces

Journal of Numerical Analysis and Approximation Theory
In this paper, we present the innovative idea of ”t-frames,” frames produced by triple sequences within Hilbert spaces. The paper explores various properties of these t-frames, delving into topics like frame operators, alternative dual frames, and the ...
Asif H. Jan, Younis A. Bhat, Tanweer Jalal, Neyaz Sheikhh   +3 more
doaj   +1 more source

Usage of Pythagorean Triple Sequence in OSPF

Communications and Network, 2012
Shutting down a link for the purposes of a scheduled routine maintenance does cause the forwarding path to change. If these changes are not done in a required order will cause not only transient micro loops but also an overload in some links. Currently, some ISP operators use a graceful link shutdown procedure by first setting up the Interior Gateway ...
Simon Tembo, Ken-ichi Yukimatsu, Shohei Kamamura, Takashi Miyamura, Kohei Shiomoto, Atsushi Hiramatsu   +5 more
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Triple sequences and their statistical convergence

, 2006
Pringsheim gave the definition of the convergence for double sequences in 1900. The idea of statistical convergence was first presented by Fast in 1951. In 2003 Tripathy and Mursaleen et.al introduced statistical convergence of double sequences. In this article we introduce the notions of triple sequences and statistically convergent triple sequence ...
FATMA KADRİYE, DÜDEN, ŞAHİNER, Ahmet, GÜRDAL, Mehmet   +2 more
openaire   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source