Results 81 to 90 of about 369,224 (281)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

To unwind the biological knots: The DNA/RNA G‐quadruplex resolvase RHAU (DHX36) in development and disease

open access: yesAnimal Models and Experimental Medicine, 2022
The G‐quadruplex (G4) sequences are short fragments of 4‐interval triple guanine (G) with frequent and ubiquitous distribution in the genome and RNA transcripts.
Chensi Yang   +5 more
doaj   +1 more source

A Note on Multiplicative Triple Fibonacci Sequences [PDF]

open access: yesThe Bulletin of Society for Mathematical Services and Standards, 2015
In this paper, multiplicative triple Fibonacci sequences have been discussed. Here the results obtained by Singh et.al [3] have been extended. Some new theorems have been established.
Satish Kumar, Hari Kishan, Deepak Gupta
openaire   +1 more source

If the Current Clique Algorithms are Optimal, so is Valiant's Parser

open access: yes, 2015
The CFG recognition problem is: given a context-free grammar $\mathcal{G}$ and a string $w$ of length $n$, decide if $w$ can be obtained from $\mathcal{G}$. This is the most basic parsing question and is a core computer science problem.
Abboud, Amir   +2 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Empirical Coordination in a Triangular Multiterminal Network

open access: yes, 2013
In this paper, we investigate the problem of the empirical coordination in a triangular multiterminal network. A triangular multiterminal network consists of three terminals where two terminals observe two external i.i.d correlated sequences.
Aref, Mohammad Reza   +3 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Tauberian theorems for (N̄, p, q, w) summable triple sequences of fuzzy numbers

open access: yesCQD Revista Eletrônica Paulista de Matemática
In this paper, we introduce the notion of weighted mean method (N̄, p, q, w) of triple sequences of fuzzy numbers and and show necessary and sufficient Tauberian conditions under which convergence in Pringsheim's sense of a triple sequence of fuzzy ...
Carlos Bernal Granados   +2 more
doaj   +1 more source

Non-commutative geometry, dynamics, and infinity-adic Arakelov geometry [PDF]

open access: yes, 2003
In Arakelov theory a completion of an arithmetic surface is achieved by enlarging the group of divisors by formal linear combinations of the ``closed fibers at infinity''.
Consani, Caterina, Marcolli, Matilde
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

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