Results 81 to 90 of about 151,657 (257)

Hybrid Steepest Descent Viscosity Method for Triple Hierarchical Variational Inequalities

Abstract and Applied Analysis, 2012
We consider a triple hierarchical variational inequality problem (in short, THVIP). By combining hybrid steepest descent method, viscosity method, and projection method, we propose an approximation method to compute the approximate solution of THVIP.
L.-C. Ceng, Q. H. Ansari, C.-F. Wen
doaj   +1 more source

Diophantine triples in a Lucas-Lehmer sequence [PDF]

Annales Mathematicae et Informaticae, 2018
Summary: In this paper, we define a Lucas-Lehmer type sequence denoted by $(L_n)_{n=0}^{\infty}$, and show that there are no integers $0 < a < b < c$ such that $ab + 1, ac + 1$, and $bc + 1$ all are terms of the sequence.
openaire   +5 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A Study of Triple Sequence Spaces

We have great pleasure in presenting this text book of mathematics. This book is intended primarily for students of science and engineering. Its aims are, first, to present the fundamental mathematical ideas which underlie the notion of a convergent sequences, and secondly to develop, as far as the small spaces allows, a body of technique and a ...
Khan, Vakeel A., Esi, Ayhan, Subramanian, Nagarajan, Fatima, Hira   +3 more
openaire   +2 more sources

Triple Sequence Learning for Cross-domain Recommendation

ACM Transactions on Information Systems
Cross-domain recommendation (CDR) aims at leveraging the correlation of users’ behaviors in both the source and target domains to improve the user preference modeling in the target domain. Conventional CDR methods typically explore the dual-relations between the source and target domains’ behaviors.
Haokai Ma, Ruobing Xie, Lei Meng 0001, Xin Chen 0091, Xu Zhang 0028, Leyu Lin, Jie Zhou 0016   +6 more
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Ascent Sequences Avoiding a Triple of Length-3 Patterns

The Electronic Journal of Combinatorics
An ascent sequence is a sequence $a_1a_2\cdots a_n$ consisting of non-negative integers satisfying $a_1=0$ and for $1<i\leq n$, $a_i\leq \text{asc}(a_1a_2\cdots a_{i-1})+1$, where $\text{asc}(a_1a_2\cdots a_k)$ is the number of ascents in the sequence $a_1a_2\cdots a_k$.
David Callan, Toufik Mansour
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Triple NF-kB binding sites and LTR sequence similarities in HIV-1C isolates irrespective of helminth co-infection

Parasites & Vectors, 2014
Background Helminth infections as well as structural alternations in the long-terminal repeat (LTR) regions of HIV-1 are known to contribute to elevated HIV RNA level and enhance HIV-1 diseases progression.
Andargachew Mulu, Melanie Maier, Uwe Gerd Liebert   +2 more
doaj   +1 more source