Results 101 to 110 of about 928,403 (288)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Indecomposable triple systems

Discrete Mathematics, 1974
AbstractA t-design (λ, t, d, n) is a system B of sets of size d from an n-set S, such that each t subset of S is contained in exactly λ elements of B. A t-design is indecomposable (written IND(λ, t, d, n)) if there does not exist a subset B ⊆ B such that B is a (λ, t, d, n) for some λ, 1 ⩽ λ < λ. A triple system is a (λ; 2, 3, n).
openaire   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

As dimensões da sustentabilidade dos Sistemas Agroflorestais – SAFs: um estudo no Projeto de Reflorestamento Consorciado e Adensado – RECA, Ponta do Abunã – RO

Desenvolvimento e Meio Ambiente, 2016
The study aimed to determine the contribution of Joint Venturer for Economic Reforestation (Reflorestamento Econômico Consorciado e Adensado, RECA), which is an agroforestry system, organized in communities which produce peach palm, Brazil nut, cupuaçu ...
Ana Íris Tomás Vasconcelos, Editinete André da Rocha Garcia, Cora Franklina Carmo Furtado, José Ednilson de Oliveira Cabral   +3 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Design and Analysis of Self Recoverable Triple Node Upset Hardened Latch With Novel Triple Input-Dual Output C-Element for Aerospace Applications

IEEE Access
Designing fault resilient storage components is a significant challenge in radiation-hardened systems, as CMOS scaling causes systems to be more susceptible to radiation-induced Multiple-Node Upsets (MNUs). The proposed Triple input-Dual output C-element-
Shaik Asiya, Rajeev Pankaj Nelapati
doaj   +1 more source

Directed triple systems

Journal of Combinatorial Theory, Series A, 1973
AbstractDirected triple systems are an example of block designs on directed graphs. A block design on a directed graph can be defined as follows. Let G be a directed graph of k vertices which contain no loops. Let S be a set of υ elements. A collection of k-subsets of S with an assignment of the elements of each k-subset to the vertices of G is called ...
Hung, Stephen H.Y, Mendelsohn, N.S
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

On the Block Coloring of Steiner Triple Systems

Journal of Mathematical Extension, 2014
A Steiner triple system of order v, STS(v), is an ordered pair S = (V, B), where V is a set of size v and B is a collection of triples of V such that every pair of V is contained in exactly one triple of B.
R. Manaviyat
doaj  

The Evolution of Binaries Embedded Within Common Envelopes

The Astrophysical Journal
Triple stellar systems allow us to study stellar processes that cannot be attained in binary stars. The evolutionary phases in which the stellar members undergo mass exchanges can alter the hierarchical layout of these systems.
Alejandra Rosselli-Calderon, Ricardo Yarza, Ariadna Murguia-Berthier, Valeriia Rohoza, Rosa Wallace Everson, Andrea Antoni, Morgan MacLeod, Enrico Ramirez-Ruiz   +7 more
doaj   +1 more source