Results 111 to 120 of about 9,480,720 (296)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Lie Triple Systems, Restricted Lie Triple Systems, and Algebraic Groups

Journal of Algebra, 2001
A Lie triple system may be defined as the odd part of a \({\mathbb Z}_2\)-graded Lie algebra, with the ternary operation given by \([xyz]=[[x,y],z]\) (inside the Lie algebra). The aim of the paper is to study the Lie triple systems related to the pairs \((G,\theta)\), where \(G\) is a simple and simply connected algebraic group over an algebraically ...
openaire   +1 more source

On a method of comparison for triple-systems [PDF]

Transactions of the American Mathematical Society, 1914
1. Itf n elements 1, 2, 3, *** n can be distributed in triads in such a way that every pair of elements appears in one and only one triad, the totality of triads forms a triple-system of n elements. Reissf has shown that it is possible to form a triple-system of n elements provided n is of the form 6m + 1 or 6m + 3.
openaire   +1 more source

Metallic Triple Beam Resonator with Thick-film Printed Drive and Pickup

, 2003
A triple beam resonator fabricated in 430S17 stainless steel with thick-film piezoelectric elements to drive and detect the vibrations is presented. The resonator substrate was fabricated by a simultaneous, double-sided photochemical etching technique ...
Yan, T, Tudor, M, Jones, B, Rakowski, R, White, N, Beeby, S   +5 more
core   +1 more source

Stability of Circumbinary Orbits in Misaligned Triple-star Systems

The Astrophysical Journal
We investigate the stability of circumbinary orbits in hierarchical triple-star systems, focusing on the effects of a misaligned outer companion star.
Stephen Lepp, Rebecca G. Martin
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Embedding partial triple systems

Journal of Combinatorial Theory, Series A, 1987
The main result of this paper is that any partial triple system (S,B) of index \(\lambda\) on n points can be embedded in a triple system of any odd \(\lambda\)-admissible order greater than 4n. Furthermore, if the minimum degree, maximum degree and total number of edges in the missing-edge graph of (S,B) satisfy certain bounds, then (S,B) can be ...
Christopher A. Rodger, S. J. Stubbs
openaire   +2 more sources

Unresolved triple systems in the aged open cluster Trumpler 19: Discovery, confirmation, and implications★

Astronomy & Astrophysics
Context. It is difficult to identify unresolved triple and higher-order systems beyond the solar vicinity. Star clusters yield controlled environments with known physical parameters, providing a way to explore homogeneous stellar samples. Aims. Combining
Minniti D., Saito R. K., Ivanov V. D., Obasi C. O., Gómez M., Lucas P. W., Fernández-Trincado J. G., Alonso-García J., Garro E. R., Corral-Santana J., Luna A., Guo Z., Kurtev R., Borissova J., Fermiano V., Osses J., Morris C., Dias B., Cáceres C., Saroon S., Pullen J. B., Rodriguez P., Lad M., Federle S., Petralia I., Bhadrakumar D., Esteves P., Navarro M. G., Palma T., Baravalle L., Galdeano D., Alonso M. V., Nilo Castellon J. L., Chené A. N.   +33 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source