Results 81 to 90 of about 928,403 (288)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Some Problems and Conjectures About Voloshin Triple Systems

Mathematics
In this paper we give a short survey of Voloshin Triple Systems, which are Steiner Triple Systems with a vertex colouring which colour the blocks using exactly two colours.
Mario Gionfriddo
doaj   +1 more source

Nowcasting in Triple-System Estimation

Journal of Official Statistics
Multiple systems estimation uses samples that each cover part of a population to obtain a total population size estimate. Ideally, all available samples are used, but if some samples are available (much) later, one may use only the samples that are available early. Under some regularity conditions, including sample independence, two samples are enough
Daan B. Zult, Peter G. M. van der Heijden, Bart F. M. Bakker   +2 more
openaire   +4 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Identifying Hierarchically Triple Star Systems with Gaia DR3 and LAMOST

The Astronomical Journal
Triple star systems are critical for understanding stellar dynamics and compact objects in astrophysics, yet confirmed hierarchical triples identified via spectroscopy remain limited.
Tongyu He, Jiao Li, Jiangdan Li, Jianping Xiong, Xiaobin Zhang, Mikhail Kovalev, Qiyuan Cheng, Sufen Guo, Mingkuan Yang, Xuefei Chen, Zhanwen Han   +10 more
doaj   +1 more source

Periodic Motion and Stability of Gravitational Planar Triple Systems

Frontiers in Astronomy and Space Sciences, 2019
The stability of gravitational triple systems is a well-known problem in celestial mechanics. The basic model used is the general three body problem (GTBP).
George Voyatzis, Athanasios Mourtetzikoglou   +1 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Controlled Release of Doxorubicin from the Drug Delivery Formulation Composed of Single-Walled Carbon Nanotubes and Congo Red: A Molecular Dynamics Study and Dynamic Light Scattering Analysis

Pharmaceutics, 2020
The controlled delivery and release of drug molecules at specific targets increases the therapeutic efficacy of treatment. This paper presents a triple complex which is a new potential drug delivery system.
Anna Jagusiak, Katarzyna Chlopas, Grzegorz Zemanek, Pawel Wolski, Tomasz Panczyk   +4 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Approximate Homomorphisms and Derivations on Normed Lie Triple Systems

Journal of Function Spaces, 2014
We investigate the generalized Hyers-Ulam stability of homomorphisms and derivations on normed Lie triple systems for the following generalized Cauchy-Jensen additive equation r0f((s∑j=1pxj+t∑j=1dyj)/r0)=s∑j=1p‍f(xj)+t∑j=1d‍f(yj), where r0,s, and  t are ...
Hark-Mahn Kim, Juri Lee
doaj   +1 more source