Results 91 to 100 of about 1,723 (256)
Orthopaedic Journal of Sports Medicine, 2014 Objectives: To evaluate the long-term results of primary Anterior Cruciate Ligament (ACL) reconstructions using either allograft or autograft. Methods: From June 2002 to August 2003, patients with a symptomatic ACL deficient knee were randomized to ...
Craig R. Bottoni MD +6 more
doaj +1 more source
300 GHz active frequency-tripler MMICs
, 2022 S.236-239An active frequency-tripler MMIC achieving an output frequency of 315 GHz is presented. Without the use of postamplification the frequency-tripler generates an average output power of -10.1 dBm in the output frequency range from 285 to 315 GHz ...
Leuther, Arnulf +5 more
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Positional cyanosis reveals platypnea-orthodeoxia-syndrome
Respiratory Medicine Case Reports, 2019 Platypnea-orthodeoxia syndrome is a rare cause of dyspnea, which presents upon standing and resolves when supine. Etiology is multifactorial with a functional component and an anatomical shunt. The most commonly reported shunt is an atrial septal defect,
Colin M. Kenny +3 more
doaj +1 more source
A 141-GHz Quasi-Optical HBV Diode Frequency Tripler
, 1999 A 141-GHz quasi-optical heterostructure barrier varactor (HBV) diode frequency tripler is presented. The tripler consists of two slot antennas loaded with FEW diodes and located at the focal plane of a dielectric lens. A quasi-optical high-pass filter is
Dillner, Lars +4 more
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
0.24 W F-Band Heterostructure Barrier Varactor Frequency Tripler
, 2007 We have designed, grown, fabricated and characterized a 111 GHz frequency tripler. An AlAs/InAlAs/InGaAs heterostructure barrier varactor (HBV) was used as the nonlinear device for generating higher order harmonics.
Sadeghi, Mahdad +3 more
core +1 more source
Cerebral Vasculitis in Juvenile Rheumatoid Arthritis
Pediatric Neurology Briefs, 1998 A 16-year-old girl who developed a stroke after a 5-year history of polyarticular juvenile rheumatoid arthritis is reported from Tripler Army Medical Center, Honolulu, Hawaii.
J Gordon Millichap
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source