Results 61 to 70 of about 6,814 (284)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Topological interface modes in 3D-printed triply periodic minimal surface phononic crystals

Materials & Design
Triply periodic minimal surface (TPMS)-based continuous structures have recently attracted increased attention due to their remarkable mechanical properties, such as high strength-to-weight ratio, impact resistance, and energy absorption capabilities. In
Prabhakaran Manogharan, Alper Erturk
doaj   +1 more source

Electronic structure of periodic curved surfaces -- continuous surface versus graphitic sponge

, 2003
We investigate the band structure of electrons bound on periodic curved surfaces. We have formulated Schr\"{o}dinger's equation with the Weierstrass representation when the surface is minimal, which is numerically solved.
Aoki, Chan, D. Takeda, Fujita, H. Aoki, H. Morise, Ikegami, K. Kuroki, Lenosky, M. Koshino, MacKay, O'Keefe, Schwarz, Terrones, Townsend, Townsend, Vanderbilt   +16 more
core   +1 more source

Appearance of the Single Gyroid Network Phase in Nuclear Pasta Matter [PDF]

, 2014
Nuclear matter under the conditions of a supernova explosion unfolds into a rich variety of spatially structured phases, called nuclear pasta. We investigate the role of periodic network-like structures with negatively curved interfaces in nuclear pasta ...
Iida, K., Klatt, M. A., Maruhn, J. A., Mecke, K., Reinhard, P. -G., Schroeder-Turk, G. E., Schuetrumpf, B.   +6 more
core   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The shape of two-dimensional space [PDF]

, 2002
Genomics, so fashionable today, is only half of the secret of life. The other half of the secret is shape, form, morphogenesis and metamorphosis.
Mackay, Alan L.
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Hollow vortices and minimal surfaces [PDF]

, 2014
We consider an overdetermined elliptic problem known as the hollow vortex problem. We prove that the solutions to this problem are in 1:1 correspondence with minimal graphs bounded by horizontal symmetry lines.
Martin Traizet, Van Dyke M.
core   +4 more sources

Density-functional theory and triply-periodic minimal surfaces

Physical Review Materials
Several authors have suggested that the surfaces of vanishing potential generated by the electrostatic fields from a periodic distribution of point charges resemble triply-periodic minimal surfaces (TPMS) whose symmetry corresponds to the positions of the point charges.
Mengdi Yin, Jing Zhang, Dimitri D. Vvedensky   +2 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source