Results 61 to 70 of about 1,157 (193)

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

Triply periodic minimal surfaces for thermo-mechanical protection

Scientific Reports
Triply periodic minimal surface (TPMS) metamaterials show promise for thermal management systems but are challenging to integrate into existing packaging with strict mechanical requirements. Composite TPMS lattices may offer more control over thermal and
Samantha Cheung, Jiyun Kang, Yujui Lin, Kenneth E. Goodson, Mehdi Asheghi, X. Wendy Gu   +5 more
doaj   +1 more source

Topological interface modes in 3D-printed triply periodic minimal surface phononic crystals

Materials & Design
Triply periodic minimal surface (TPMS)-based continuous structures have recently attracted increased attention due to their remarkable mechanical properties, such as high strength-to-weight ratio, impact resistance, and energy absorption capabilities. In
Prabhakaran Manogharan, Alper Erturk
doaj   +1 more source

Tracking CDK1 Dynamics With a Novel Biosensor Mouse and Clinical Cohorts to Predict CDK4/6 Inhibitor Sensitivity in ER+ Breast Cancer

Advanced Science, EarlyView.
Cyclin‐dependent kinase (CDK) 1 activity is a dynamic marker of treatment response in estrogen receptor positive breast cancer. Patient cohorts reveal CDK1 activity increases during progression to invasive disease, where high expression correlates with poor survival. Using a novel Cdk1 biosensor mouse alongside in vitro models, we demonstrate that CDK1
Sarah Alexandrou, Kristine J. Fernandez, Min Li Huang, Ewan K. A. Millar, Claire Vennin, Leila Eshraghi, Tan Dat Timothy Lam, Victoria Lee, Nyah C. Brooks, Janett Stoehr, Cristian Guaman Mendez, Douglas Strathdee, David Stevenson, David Herrmann, Sandra O'Toole, Paul Timpson, Max Nobis, C. Elizabeth Caldon   +17 more
wiley   +1 more source

Intelligent generative design: a transfer learning-enhanced bidirectional mapping framework for customised parametric structural design

Virtual and Physical Prototyping
Tissue engineering scaffolds with tailored mechanical properties are crucial for regenerative medicine. However, establishing the intricate relationships between scaffold design parameters and resulting mechanical behaviour remains a challenge.
Jiajie Hu, Yayun Wang, Hua Tian, Peng Zheng, Liang Chi, Lulu Xue, Qian Su, Qing Jiang, Yong He, Lan Li, Liya Zhu   +10 more
doaj   +1 more source

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

NURBS-based explicit triply periodic minimal surfaces reconstruction for porous design and isogeometric analysis

Materials & Design
Triply periodic minimal surface structures are increasingly used in high-performance engineering applications, but their complex topology and implicit representation hinder integration with conventional CAD/CAE systems. This work proposes a unified NURBS-
Jiayi Li, Zhaoyun Liu, Shengxue Wang, Xiaoxiao Du, Gang Zhao   +4 more
doaj   +1 more source

Enhancing Specific Stiffness of Nano‐Architected Materials Through Generative AI and Active Learning

Advanced Science, EarlyView.
A structure‐centric generative framework searches voxelated design space directly, coupling a variational autoencoder with multi‐objective optimization and active learning to progressively expand the validated design domain. The discovered nano‐architectures, realized as pyrolytic carbon by two‐photon lithography, deliver 18–23% higher stiffness and 26–
Jinwook Yeo, Peter Serles, Donggeun Park, Julia R. Greer, Seunghwa Ryu   +4 more
wiley   +1 more source

Version [2.0]- [MaSMaker: An open-source, portable software to create and integrate maze-like surfaces into arbitrary geometries]

SoftwareX
MaSMaker 2.0 aims to contribute to the computational design and fabrication of Triply Periodic Minimal Surface (TPMS) structures. This updated version expands the capabilities of the software in three aspects: (1) the repertoire of available TPMS ...
James Pérez-Barrera, Arturo Gómez-Ortega, Mauricio Ivan Tenorio-Suárez, Katia Corrales-Camacho, Saul Piedra, Christian Félix-Martínez   +5 more
doaj   +1 more source

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source