Results 51 to 60 of about 2,237,494 (278)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Heat transfer in a porous medium having an ordered gyroid-based macrostructure

Российский технологический журнал
Objectives. Triply periodic minimal surfaces are non-intersecting surfaces with zero mean curvature, consisting of elements repeating in three directions of the Cartesian coordinate system.
A. I. Popov, А. V. Eremin
doaj   +1 more source

Computation of Minimal Realizations of Periodic Systems [PDF]

, 1998
We propose balancing related numerically reliable methods to compute minimal realizations of linear periodic systems with time-varying dimensions. The first method belongs to the family of square-root methods with guaranteed enhanced computational ...
Varga, A.
core  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Forced convection heat transfer in heat sinks with topologies based on triply periodic minimal surfaces

Case Studies in Thermal Engineering, 2022
This study numerically and experimentally investigates the forced convection heat transfer in three mathematically designed heat sinks with lattice topologies based on triply periodic minimal surfaces (TPMS).
Mohamad Khalil, Mohamed I. Hassan Ali, Kamran A. Khan, Rashid Abu Al-Rub   +3 more
doaj   +1 more source

The T and CLP families of triply periodic minimal surfaces. Part 1. Derivation of parametric equations

, 1992
The local Weierstrass representation of all members of the T and CLP families of triply periodic minimal surfaces involves integrals of the function $R(\tau)=1/\sqrt{\tau^8+\lambda\tau^4+1}$ (with $-\infty
Jacek Klinowski, Djurdje Cvijović
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Experimental and numerical characterization of imperfect additively manufactured lattices based on triply periodic minimal surfaces

Materials & Design, 2023
Lattices based on triply periodic minimal surfaces (TPMS) are attracting increasing interest in seminal industries such as bone tissue engineering due to their excellent structure-property relationships.
Fabian Günther, Stefan Pilz, Franz Hirsch, Markus Wagner, Markus Kästner, Annett Gebert, Martina Zimmermann   +6 more
doaj   +1 more source

A reducibility for a triply periodic minimal surface

Advanced Studies in Pure Mathematics, 2019
In this paper, we define a reducibility for a triply periodic minimal surface, and study hyperelliptic minimal surfaces and trigonal minimal surfaces in terms of the reducibility. Restrictions on the topological type of the above minimal surfaces are given.
openaire   +2 more sources