Results 161 to 170 of about 116,083 (186)
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European Neurology, 2000
The neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 bind to the tyrosine kinase (trk) receptors trk A, trk B and trk C, respectively, with high affinity. We investigated the expression of the trk receptors in the parietal cortex (PC) and cerebellum of patients with Alzheimer’s disease (AD) and age-matched ...
E, Savaskan +7 more
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The neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 bind to the tyrosine kinase (trk) receptors trk A, trk B and trk C, respectively, with high affinity. We investigated the expression of the trk receptors in the parietal cortex (PC) and cerebellum of patients with Alzheimer’s disease (AD) and age-matched ...
E, Savaskan +7 more
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Indole-like Trk receptor antagonists
European Journal of Medicinal Chemistry, 2016The virtual screening for new scaffolds for TrkA receptor antagonists resulted in potential low molecular weight drug candidates for the treatment of neuropathic pain and cancer. In particular, the compound (Z)-3-((5-methoxy-1H-indol-3-yl)methylene)-2-oxindole and its derivatives were assessed for their inhibitory activity against Trk receptors.
Jaana Tammiku-Taul +11 more
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Science Signaling, 2003
Neurotrophins promote neuron survival and maturation and support the development and function of neural tissue and organs. They bind to and activate receptor tyrosine kinases of the Trk family. However, truncated forms of TrkB and TrkC that lack the intracellular kinase domain are expressed primarily in glial cells, and their function has ...
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Neurotrophins promote neuron survival and maturation and support the development and function of neural tissue and organs. They bind to and activate receptor tyrosine kinases of the Trk family. However, truncated forms of TrkB and TrkC that lack the intracellular kinase domain are expressed primarily in glial cells, and their function has ...
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Expression patterns of Trk-A, Trk-B, GRP78, and p75NRT in olfactory neuroblastoma
Human Pathology, 2009Olfactory neuroblastoma is an uncommon neuroectodermal tumor of the sinonasal tract. It represents 2% to 3% of sinonasal neoplasms. Most olfactory neuroblastoma behave locally aggressive with 30% recurrence rates. A subset metastasizes to lymph nodes and/or distant sites.
Ilan, Weinreb +3 more
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Science, 2002
Nerve growth factor binds to TrkA receptors on axon terminals, generating a survival signal that is propagated along the axon to the cell body of the neuron. In their Perspective, [Miller and Kaplan][1] discuss exciting new findings ([MacInnis and Campenot][2]) demonstrating that nerve growth factor does not have to be internalized with its receptor ...
Freda D. Miller, David R. Kaplan
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Nerve growth factor binds to TrkA receptors on axon terminals, generating a survival signal that is propagated along the axon to the cell body of the neuron. In their Perspective, [Miller and Kaplan][1] discuss exciting new findings ([MacInnis and Campenot][2]) demonstrating that nerve growth factor does not have to be internalized with its receptor ...
Freda D. Miller, David R. Kaplan
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2015
The Trk family is composed of three principal members (A, B and C), also termed neurotrophin tyrosine kinase receptors (NTRK1, NTRK2, NTRK3), with several additional splice variants, which in humans are located on three different chromosomes (1, 9, 15).
Hondermarck, Hubert +2 more
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The Trk family is composed of three principal members (A, B and C), also termed neurotrophin tyrosine kinase receptors (NTRK1, NTRK2, NTRK3), with several additional splice variants, which in humans are located on three different chromosomes (1, 9, 15).
Hondermarck, Hubert +2 more
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Science Signaling, 2000
Upon binding to nerve growth factor (NGF), the receptor tyrosine kinase TrkA dimerizes and becomes activated. Two immunoglobulin-like regions in the receptor's extracellular domain bind to NGF. However, in the absence of ligand, Arevalo et al. report that these two domains may actually prevent receptor dimers from
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Upon binding to nerve growth factor (NGF), the receptor tyrosine kinase TrkA dimerizes and becomes activated. Two immunoglobulin-like regions in the receptor's extracellular domain bind to NGF. However, in the absence of ligand, Arevalo et al. report that these two domains may actually prevent receptor dimers from
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Larotrectinib bei TRK-Fusionstumoren
Onkologische Welt, 2019Wirkstoff Larotrectinib hat im September 2019 eine EU-Zulassung zur Behandlung von erwachsenen und pädiatrischen Patienten mit TRK-Fusionstumoren erhalten. Der orale Wirkstoff ist der erste Vertreter einer neuen Arzneimittelklasse, der gezielt den onkogenen Treiber eines Tumors inhibiert.
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Science's STKE, 2005
No true invertebrate homologs of the vertebrate neurotrophin Trk receptors have been identified in the genomes of the model organisms Drosophila melanogaster and Caenorhabditis elegans , which has led to the hypothesis that the Trk signaling arose in vertebrates. Benito-Gutiérrez
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No true invertebrate homologs of the vertebrate neurotrophin Trk receptors have been identified in the genomes of the model organisms Drosophila melanogaster and Caenorhabditis elegans , which has led to the hypothesis that the Trk signaling arose in vertebrates. Benito-Gutiérrez
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