Results 1 to 10 of about 27,380 (228)
Expression of Nerve Growth Factor and Its Receptor TrkA in the Reproductive System of Adult Zebrafish [PDF]
Veterinary Sciences, 2022 Nerve growth factor (NGF), a member of the neurotrophin family, has emerged as an active mediator in different crucial events in the peripheral and central nervous system.
Pietro Cacialli
doaj +2 more sources
Unveiling the TrkA-p35/CDK5 axis: a novel therapeutic target in diabetic kidney disease [PDF]
Frontiers in EndocrinologyObjectiveTo investigate the potential crosstalk between TrkA, the high-affinity nerve growth factor receptor (NGFR), and cyclin-dependent kinase 5 (CDK5) in the pathogenesis of diabetic kidney disease (DKD).
Wenbo Xia +10 more
doaj +2 more sources
The Receptor Tyrosine Kinase TrkA Is Increased and Targetable in HER2-Positive Breast Cancer
Biomolecules, 2020 The tyrosine kinase receptor A (NTRK1/TrkA) is increasingly regarded as a therapeutic target in oncology. In breast cancer, TrkA contributes to metastasis but the clinicopathological significance remains unclear.
Nathan Griffin +2 more
exaly +3 more sources
TrkA activation sustains chemotherapy resistance in chemotolerant medulloblastoma cells [PDF]
Acta Neuropathologica CommunicationsMedulloblastoma (MB), one of the most common pediatric brain tumors, is reported to resist treatments in almost 30% of cases, allowing for the emergence of fatal recurrences.
Lorenzo Manfreda +6 more
doaj +2 more sources
Discovery of a Proteolysis Targeting Chimera for TRKA and RET-derived oncoproteins [PDF]
Scientific ReportsWe designed Proteolysis Targeting Chimeras (PROTACs) to target Tropomyosin Receptor Kinase A (TRKA) and Rearranged during Transfection (RET) oncogenic proteins.
Marialuisa Moccia +7 more
doaj +2 more sources
Frontiers in Molecular Neuroscience, 2023 IntroductionAxonal transport of pro nerve growth factor (proNGF) is impaired in aged basal forebrain cholinergic neurons (BFCNs), which is associated with their degeneration.
Erika Kropf +5 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2023 IntroductionThe neurotrophin system plays a pivotal role in the development, morphology, and survival of the nervous system, and its dysregulation has been manifested in numerous neurodegenerative and neuroinflammatory diseases.
Daniele Narducci +15 more
doaj +1 more source
Enhanced TrkA signaling impairs basal forebrain-dependent behavior
Frontiers in Molecular Neuroscience, 2023 Basal forebrain cholinergic neurons (BFCNs) modulate cognitive functions such as attention, learning and memory. The NGF/TrkA pathway plays an important role in the development and function of BFCNs, although two mouse models conditionally deleting TrkA ...
Laura Calvo-Enrique +9 more
doaj +1 more source
Effect of Synthetic Cell-Penetrating Peptides on TrkA Activity in PC12 Cells
Journal of Pharmacological Sciences, 2008 As TrkA, a high-affinity receptor of nerve growth factor (NGF), is a potential target for relieving uncontrolled inflammatory pain, an effective inhibitor of TrkA has been required for pain management.
Munetaka Hirose +14 more
doaj +1 more source
NGF, TrkA-P and neuroprotection after a hypoxic event in the developing central nervous system [PDF]
, 2018 A decrease in the concentration of oxygen in the blood and tissues (hypoxia) produces important, sometimes irreversible, damages in the central nervous system (CNS) both during development and also postnatally.
Bogetti, María Eugenia +4 more
core +1 more source