NGF causes TrkA to specifically attract microtubules to lipid rafts. [PDF]
PLoS ONE, 2012 Membrane protein sorting is mediated by interactions between proteins and lipids. One mechanism that contributes to sorting involves patches of lipids, termed lipid rafts, which are different from their surroundings in lipid and protein composition ...
Shona Pryor +3 more
doaj +1 more source
Trophic and neurotrophic factors in human pituitary adenomas (Review) [PDF]
, 2017 The pituitary gland is an organ that functionally connects the hypothalamus with the peripheral organs. The pituitary gland is an important regulator of body homeostasis during development, stress, and other processes.
Agostinelli, Enzo +11 more
core +1 more source
NGF is an essential survival factor for bronchial epithelial cells during respiratory syncytial virus infection. [PDF]
PLoS ONE, 2009 BACKGROUND:Overall expression of neurotrophins in the respiratory tract is upregulated in infants infected by the respiratory syncytial virus (RSV), but it is unclear where (structural vs. inflammatory cells, upper vs.
Sreekumar Othumpangat +3 more
doaj +1 more source
Production of a Monoclonal Antibody Directed against the High-Affinity Nerve Growth Factor Receptor
The International Journal of Biological Markers, 1999 The high-affinity nerve growth factor receptor corresponds to the tyrosine protein kinase encoded by the proto-oncogene trkA. Different findings suggest that nerve growth factor (NGF) can be operative in the growth modulation of tumor cell lines ...
E. Tagliabue +8 more
doaj +1 more source
Novel mutations in UL24 and gH rescue efficient infection of an HSV vector retargeted to TrkA
Molecular Therapy: Methods & Clinical Development, 2023 Transductional targeting of herpes simplex virus (HSV)-based gene therapy vectors offers the potential for improved tissue-specific delivery and can be achieved by modification of the viral entry machinery to incorporate ligands that bind the desired ...
Marco Marzulli +5 more
doaj +1 more source
Non-Aβ-dependent factors associated with global cognitive and physical function in alzheimer's disease: a pilot multivariate analysis [PDF]
, 2019 Recent literature highlights the importance of identifying factors associated with mild cognitive impairment (MCI) and Alzheimer's Disease (AD).
Di Baldassarre, Angela +14 more
core +2 more sources
Functional expression of TrkA receptors in hippocampal neurons
Journal of Neuroscience Research, 1998 Nerve growth factor (NGF) initiates its biological effects by promoting the dimerization and activation of the tyrosine kinase receptor TrkA. The requirements for NGF signaling through the TrkA receptor have been defined extensively from studies in immortalized cells, involving transfection of NIH 3T3, COS, and PC12 cells.
Aibel, Lani +3 more
openaire +3 more sources
NEAP/DUSP26 suppresses receptor tyrosine kinases and regulates neuronal development in zebrafish
Scientific Reports, 2017 Expression of neuroendocrine-associated phosphatase (NEAP, also named as dual specificity phosphatase 26, [DUSP26]) is restricted to neuroendocrine tissues. We found that NEAP, but not its phosphatase-defective mutant, suppressed nerve growth factor (NGF)
Chi-Hwa Yang +9 more
doaj +1 more source
ProNGF and Neurodegeneration in Alzheimer’s Disease
Frontiers in Neuroscience, 2019 Profound and early basal forebrain cholinergic neuron (BFCN) degeneration is a hallmark of Alzheimer’s disease (AD). Loss of synapses between basal forebrain and hippocampal and cortical target tissue correlates highly with the degree of dementia and is ...
Margaret Fahnestock, Arman Shekari
doaj +1 more source
Frontiers in Chemistry, 2023 Tropomyosin-receptor kinase A (TrkA) is the primary isoform among the tropomyosin-receptor kinases that have been associated with human cancer development, contributing to approximately 7.4% of all cancer cases.
Rua M. Mukhtar +20 more
doaj +1 more source