Results 21 to 30 of about 1,251,047 (226)

TrkA neutrophin receptor protein in the rat and human thymus [PDF]

The Anatomical Record, 1997
Increasing evidence suggests that nerve growth factor (NGF), and probably other neurotrophins, are involved in the control of lymphoid organs and immunocompetent cells that express neurotrophins and/or their receptors. In the rat thymus, mRNA for TrkA (an essential component of the NGF signal transducing receptor) has been found primarily in stromal ...
J, Hannestad, O, García-Suárez, J J, Huerta, I, Esteban, F J, Naves, J A, Vega   +5 more
openaire   +2 more sources

Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis.

PLoS Biology, 2011
The neurosteroid dehydroepiandrosterone (DHEA), produced by neurons and glia, affects multiple processes in the brain, including neuronal survival and neurogenesis during development and in aging. We provide evidence that DHEA interacts with pro-survival
Iakovos Lazaridis, Ioannis Charalampopoulos, Vassilia-Ismini Alexaki, Nicolaos Avlonitis, Iosif Pediaditakis, Paschalis Efstathopoulos, Theodora Calogeropoulou, Elias Castanas, Achille Gravanis   +8 more
doaj   +1 more source

Expression of NGF/proNGF and Their Receptors TrkA, p75NTR and Sortilin in Melanoma

International Journal of Molecular Sciences, 2022
There is increasing evidence that nerve growth factor (NGF) and its receptors, the neurotrophic receptor tyrosine kinase 1 (NTRK1/TrkA), the common neurotrophin receptor (NGFR/p75NTR) and the membrane receptor sortilin, participate in cancer growth. In melanoma, there have been some reports suggesting that NGF, TrkA and p75NTR are dysregulated, but the
Mark Marsland, Amiee Dowdell, Chen Chen Jiang, James S. Wilmott, Richard A. Scolyer, Xu Dong Zhang, Hubert Hondermarck, Sam Faulkner   +7 more
openaire   +2 more sources

Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes c-fiber nociceptors with broad action potentials and high nav1.9 expression [PDF]

, 2006
Binding to isolectin-B4 (IB4) and expression of tyrosine kinase A (trkA) (the high-affinity NGF receptor) have been used to define two different subgroups of nociceptive small dorsal root ganglion (DRG) neurons. We previously showed that only nociceptors
Fang, Xin, Dr., Fang, Xin, McMullan, Simon, Lawson, Sally N, Fang, X, Djouhri, L, Lawson, Sally N., Berry, Carol, Waxman, Stephen G., Okuse, K, McMullan, S, Djouhri, Laiche, Berry, CM, Waxman, SG, Waxman, Stephen G, Berry, C. M, Okuse, Kenji, Lawson, SN   +17 more
core   +1 more source

Nerve growth factor and its receptor tyrosine kinase TrkA are overexpressed in cervical squamous cell carcinoma

FASEB BioAdvances, 2020
Nerve growth factor (NGF) and its receptors are increasingly implicated in cancer progression, but their expression in cervical cancer is unclear. The objective of this study was to define the protein expression of NGF, its precursor (proNGF), as well as
Sam Faulkner, Nathan Griffin, Christopher W. Rowe, Phillip Jobling, Janine M. Lombard, Sonia M. Oliveira, Marjorie M. Walker, Hubert Hondermarck   +7 more
doaj   +1 more source

Mouse embryonic stem cells as a discovery tool in neurobiology [PDF]

, 2012
Mouse ES cells can recapitulate, under suitable tissue culture conditions, early events in neurogenesis. As wildtype or genetically modified ES cells can be grown in unlimited quantities, their differentiation into neurons represents an attractive model
Nikoletopoulou, Vassiliki
core   +1 more source

Extended Ceramide Exposure Activates the trkA Receptor by Increasing Receptor Homodimer Formation [PDF]

Journal of Neurochemistry, 1999
Abstract: Binding of nerve growth factor (NGF) to the trkA tyrosine kinase receptor results in receptor homodimer formation, transphosphorylation, and kinase activation that supports neuronal differentiation and survival. We have shown previously that short‐term exposure of PC12 cells to brain‐derived neurotrophic factor or to C2‐ceramide activates a ...
I, MacPhee, P A, Barker
openaire   +2 more sources

Nerve Growth Factor Signals via Preexisting TrkA Receptor Oligomers [PDF]

, 2002
Nerve growth factor (NGF) promotes neuronal survival and differentiation by activating TrkA receptors. Similar to other receptor tyrosine kinases, ligand-induced dimerization is thought to be required for TrkA receptor activation.
Zampighi, Guido A., Umbach, Joy A., Smith, Shane G., Mischel, Paul S., Eskandari, Sepehr, Gundersen, Cameron B.   +5 more
core   +1 more source

TrkA glycosylation regulates receptor localization and activity

Journal of Neurobiology, 1999
The human nerve growth factor receptor (TrkA) contains four potential N-glycosylation sites that are highly conserved within the Trk family of neurotrophin receptors, and nine additional sites that are less well conserved. Using a microscale deglycosylation assay, we show here that both conserved and variable N-glycosylation sites are used during ...
Watson, F. L., Porcionatto, Marimelia Aparecida UNIFESP, Bhattacharyya, A., Stiles, C. D., Segal, R. A.   +4 more
openaire   +2 more sources

Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling

eLife, 2018
The development of neurons in the peripheral nervous system is dependent on target-derived, long-range retrograde neurotrophic factor signals. The prevailing view is that target-derived nerve growth factor (NGF), the prototypical neurotrophin, and its ...
Mengchen Ye, Kathryn M Lehigh, David D Ginty   +2 more
doaj   +1 more source