High-affinity TrkA and p75 neurotrophin receptor complexes: A twisted affair [PDF]
Journal of Biological Chemistry, 2022 Neurotrophin signaling is essential for normal nervous system development and adult function. Neurotrophins are secreted proteins that signal via interacting with two neurotrophin receptor types: the multifaceted p75 neurotrophin receptor and the tropomyosin receptor kinase receptors. In vivo, neurons compete for the limited quantities of neurotrophins,
Jacinta N. Conroy, Elizabeth J. Coulson
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NGF causes TrkA to specifically attract microtubules to lipid rafts. [PDF]
PLoS ONE, 2012 Membrane protein sorting is mediated by interactions between proteins and lipids. One mechanism that contributes to sorting involves patches of lipids, termed lipid rafts, which are different from their surroundings in lipid and protein composition ...
Shona Pryor +3 more
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Molecular networks in FGF signaling: Flotillin-1 and Cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2 [PDF]
, 2012 Fibroblast growth factor receptor substrate 2 (FRS2α) is a signaling adaptor protein that regulates downstream signaling of many receptor tyrosine kinases.
Traub Stephanie +11 more
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Production of a Monoclonal Antibody Directed against the High-Affinity Nerve Growth Factor Receptor
The International Journal of Biological Markers, 1999 The high-affinity nerve growth factor receptor corresponds to the tyrosine protein kinase encoded by the proto-oncogene trkA. Different findings suggest that nerve growth factor (NGF) can be operative in the growth modulation of tumor cell lines ...
E. Tagliabue +8 more
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Mecanismo de activación del receptor de neurotrofinas TrkA [PDF]
, 2022 TrkA (Tropomyosin receptor kinase A) es una proteína transmembrana, miembro de la superfamilia de receptores tirosina quinasa (RTK) y receptor específico del factor de crecimiento NGF. Se ha determinado que el NGF inicia sus acciones biológicas al unirse
Franco Rivadeneira, Maria Luisa
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ProNGF and Neurodegeneration in Alzheimer’s Disease
Frontiers in Neuroscience, 2019 Profound and early basal forebrain cholinergic neuron (BFCN) degeneration is a hallmark of Alzheimer’s disease (AD). Loss of synapses between basal forebrain and hippocampal and cortical target tissue correlates highly with the degree of dementia and is ...
Margaret Fahnestock, Arman Shekari
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NGF is an essential survival factor for bronchial epithelial cells during respiratory syncytial virus infection. [PDF]
PLoS ONE, 2009 BACKGROUND:Overall expression of neurotrophins in the respiratory tract is upregulated in infants infected by the respiratory syncytial virus (RSV), but it is unclear where (structural vs. inflammatory cells, upper vs.
Sreekumar Othumpangat +3 more
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In vivo function of NGF/TrkA signaling in the cholinergic neurons of the murine basal forebrain [PDF]
, 2005 The neurotrophins are a family of secreted proteins that potently regulate diverse neuronal responses. The neurotrophin nerve growth factor (NGF) and its receptors TrkA and p75 are well characterized to control survival, differentiation and function of ...
Mueller, Markus
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NEAP/DUSP26 suppresses receptor tyrosine kinases and regulates neuronal development in zebrafish
Scientific Reports, 2017 Expression of neuroendocrine-associated phosphatase (NEAP, also named as dual specificity phosphatase 26, [DUSP26]) is restricted to neuroendocrine tissues. We found that NEAP, but not its phosphatase-defective mutant, suppressed nerve growth factor (NGF)
Chi-Hwa Yang +9 more
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Systems Pharmacology of the NGF Signaling Through p75 and TrkA Receptors [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2014 The nerve growth factor (NGF) pathway has been shown to play a key role in pain treatment. Recently, a systems pharmacology model has been proposed that can aid in the identification and validation of drug targets in the NGF pathway. However, this model did not include the role of the p75 receptor, which modulates the signaling of NGF through the ...
Toni, T, Dua, P, van der Graaf, P H
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