Results 11 to 20 of about 1,251,047 (226)

Amitriptyline is a TrkA and TrkB Receptor Agonist that Promotes TrkA/TrkB Heterodimerization and Has Potent Neurotrophic Activity [PDF]

Chemistry & Biology, 2009
Neurotrophins, the cognate ligands for the Trk receptors, are homodimers and induce Trk dimerization through a symmetric bivalent mechanism. We report here that amitriptyline, an antidepressant drug, directly binds TrkA and TrkB and triggers their dimerization and activation.
Jang, Sung Wuk, Liu, Xia, Chan, Chi Bun, Weinshenker, David, Hall, Randy A., Xiao, Ge, Ye, Keqiang   +6 more
openaire   +5 more sources

The neurotrophin receptor, gp75, forms a complex with the receptor tyrosine kinase TrkA. [PDF]

The Journal of cell biology, 1996
The high-affinity NGF receptor is thought to be a complex of two receptors , gp75 and the tyrosine kinase TrkA, but direct biochemical evidence for such an association had been lacking. In this report, we demonstrate the existence of such a gp75-TrkA complex by a copatching technique.
Ross, Alonzo H., Daou, Marie-Claire, McKinnon, Christine A., Condon, Peter J., Lachyankar, Mahesh B., Stephens, Robert M., Kaplan, David R., Wolf, David E.   +7 more
openaire   +5 more sources

Constitutive TrkA Activity in Receptor-Overexpressing PC12 Clones

Biochemical and Biophysical Research Communications, 2002
We have studied ligand-independent signaling by the nerve growth factor receptor TrkA in PC12 clones, under conditions of receptor overexpression. Our results indicate that TrkA-overexpressing PC12 clones display constitutive receptor activation, involving both the mature, 140-kDa form and the immature, intracellular 110-kDa form of the receptor ...
Leoni C, VALTORTA , FLAVIA
openaire   +3 more sources

CCM2 Mediates Death Signaling by the TrkA Receptor Tyrosine Kinase [PDF]

Neuron, 2009
The TrkA receptor tyrosine kinase is crucial for differentiation and survival of nerve-growth-factor-dependent neurons. Paradoxically, TrkA also induces cell death in pediatric tumor cells of neural origin, via an unknown mechanism. Here, we show that CCM2, a gene product associated with cerebral cavernous malformations, interacts with the ...
Harel, Liraz, Costa, Barbara, Tcherpakov, Marianna, Zapatka, Marc, Oberthuer, Andre, Hansford, Loen M., Vojvodic, Milijana, Levy, Zehava, Chen, Zhe-Yu, Lee, Francis S., Avigad, Smadar, Yaniv, Isaac, Shi, Leming, Eils, Roland, Fischer, Matthias, Brors, Benedikt, Kaplan, David R., Fainzilber, Mike   +17 more
openaire   +4 more sources

Rat visual cortical neurones express TrkA NGF receptor

Neuroreport, 2002
In this study we report the expression of TrkA receptor within the rat visual cortex during postnatal development and in adulthood, using a specific monoclonal antibody which recognizes the extracellular domain of TrkA receptor. TrkA was not detected by immunohistochemistry at postnatal day 13 (P13), i.e. before eye opening.
TROPEA D, CAPSONI, SIMONA, COVACEUSZACH S, DOMENICI L, CATTANEO, ANTONINO   +4 more
core   +7 more sources

Ligand signature in the membrane dynamics of single TrkA receptor molecules [PDF]

Journal of Cell Science, 2013
Summary The neurotrophin receptor TrkA (also known as NTRK1) is known to be crucially involved in several physio-pathological processes. However, a clear description of the early steps of ligand-induced TrkA responses at the cell plasma membrane is missing.
Laura Marchetti1, 2, Andrea Callegari1, Stefano Luin1, Giovanni Signore3, Alessandro Viegi2, Fabio Beltram1, 3, Antonino Cattaneo2   +8 more
openaire   +5 more sources

Tyrosine kinase A receptor (trkA): A potential marker in epithelial ovarian cancer [PDF]

Gynecologic Oncology, 2011
To evaluate the role of trkA receptor as a potential tumor marker in serous epithelial ovarian cancer and its relationship with the angiogenic factors expression as vascular endothelial growth factor (VEGF) and nerve growth factor (NGF). Additionally, to examine whether NGF and VEGF secreted by epithelial ovarian cancer (EOC) explants and from ...
Tapia Pinto, Verónica, Gabler Neale, Fernando, Muñoz, Marcela, Yazigi, Roberto, Selman Abuchaibe, Alberto, Vega Blanco, María Margarita, Paredes Vargas, Alfonso, Romero Osses, Carmen   +7 more
openaire   +6 more sources

Selectively Targeting Tropomyosin Receptor Kinase A (TRKA) via PROTACs

Journal of Medicinal Chemistry, 2020
Tropomyosin receptor kinases (TRKs) are promising cancer therapeutic targets. Chen et al. (J. Med. Chem. 2020, DOI: 10.1021/acs.jmedchem.0c01342) report the discovery of CG416 and CG428 as two potent small-molecule proteolysis-targeting chimera (PROTAC) degraders selective for TRKA over TRKB and TRKC.
Weiguo Xiang, Shaomeng Wang
openaire   +4 more sources

Functional interactions between the p75 neurotrophin receptor and TrkA

, 1999
Barker, Philip A. (Supervisor)
Simoneau, Steve.
openaire   +2 more sources

EXPRESSION OF TRKA RECEPTOR IN ADULT ZEBRAFISH BRAIN

, 2019
In our previous study, the presence and distribution of nerve growth factor (NGF) were described in adult zebrafish brain [1]. In mammals, the signaling of mature NGF (mNGF) is transduced by the tropomyosin receptor kinase A (TrkA) and acts as mediator in many essential functions in the central nervous system.
Adriana Petrovici, Adele Leggieri, Luciana Castaldo, Lucianna Maruccio, Carmen Solcan, Carla Lucini   +5 more
openaire   +2 more sources