Results 11 to 20 of about 27,380 (228)

TrkA Co-Receptors: The Janus Face of TrkA?

Cancers, 2023
Larotrectinib and Entrectinib are specific pan-Trk tyrosine kinase inhibitors (TKIs) approved by the Food and Drug Administration (FDA) in 2018 for cancers with an NTRK fusion. Despite initial enthusiasm for these compounds, the French agency (HAS) recently reported their lack of efficacy. In addition, primary and secondary resistance to these TKIs has
Sarah Trouvilliez, Chann Lagadec, Robert-Alain Toillon   +2 more
openaire   +3 more sources

TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis. [PDF]

J Clin Invest, 2018
Receptor tyrosine kinases (RTKs) are important drivers of cancers. In addition to genomic alterations, aberrant activation of WT RTKs plays an important role in driving cancer progression. However, the mechanisms underlying how RTKs drive prostate cancer remain incompletely characterized.
Singh R, Karri D, Shen H, Shao J, Dasgupta S, Huang S, Edwards DP, Ittmann MM, O'Malley BW, Yi P.   +9 more
europepmc   +4 more sources

Nerve Growth Factor Signals via Preexisting TrkA Receptor Oligomers [PDF]

Biophysical Journal, 2002
Nerve growth factor (NGF) promotes neuronal survival and differentiation by activating TrkA receptors. Similar to other receptor tyrosine kinases, ligand-induced dimerization is thought to be required for TrkA receptor activation. To study this process, we expressed TrkA receptors in Xenopus laevis oocytes and analyzed their response to NGF by using a ...
Mischel, Paul S., Umbach, Joy A., Eskandari, Sepehr, Smith, Shane G., Gundersen, Cameron B., Zampighi, Guido A.   +5 more
openaire   +2 more sources

ProNGF-p75NTR axis plays a proinflammatory role in inflamed joints. A novel pathogenic mechanism in chronic arthritis [PDF]

, 2017
To identify the role of mature nerve growth factor (mNGF), its immature form proNGF and their receptors in arthritis ...
Benedetti, Fabrizio De, Bracci-laudiero, Luisa, Caiello, Ivan, Magni-manzoni, Silvia, Manni, Luigi, Manzo, Antonio, Marafon, Denise Pires, Minnone, Gaetana, Prencipe, Giusi, Soligo, Marzia   +9 more
core   +1 more source

Extended Ceramide Exposure Activates the trkA Receptor by Increasing Receptor Homodimer Formation [PDF]

Journal of Neurochemistry, 1999
Abstract: Binding of nerve growth factor (NGF) to the trkA tyrosine kinase receptor results in receptor homodimer formation, transphosphorylation, and kinase activation that supports neuronal differentiation and survival. We have shown previously that short‐term exposure of PC12 cells to brain‐derived neurotrophic factor or to C2‐ceramide activates a ...
I, MacPhee, P A, Barker
openaire   +2 more sources

Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis.

PLoS Biology, 2011
The neurosteroid dehydroepiandrosterone (DHEA), produced by neurons and glia, affects multiple processes in the brain, including neuronal survival and neurogenesis during development and in aging. We provide evidence that DHEA interacts with pro-survival
Iakovos Lazaridis, Ioannis Charalampopoulos, Vassilia-Ismini Alexaki, Nicolaos Avlonitis, Iosif Pediaditakis, Paschalis Efstathopoulos, Theodora Calogeropoulou, Elias Castanas, Achille Gravanis   +8 more
doaj   +1 more source

Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches [PDF]

, 2011
Glycosaminoglycan polysaccharides play critical roles in many cellular processes, ranging from viral invasion and angiogenesis to spinal cord injury.
Bothwell, C. J. Rogers, Chao, Clement, de Paz, Dechant, Faham, Gama, Huang, K. C. Garcia, Keiser, Khunrae, Kim, L. C. Hsieh-Wilson, Lowes, Mukai, Mulloy, Oohira, P. M. Clark, Pellegrini, Petitou, R. Abrol, Raman, Rapp, Rawat, Raza, Roux, S. E. Tully, Schlessinger, Shelton, Shipp, Spivak-Kroizman, Strom, Sugahara, Sweeney, Tully, Tully, Vaudry, W. A. Goddard, Zhang   +39 more
core   +2 more sources

Nerve growth factor and its receptor tyrosine kinase TrkA are overexpressed in cervical squamous cell carcinoma

FASEB BioAdvances, 2020
Nerve growth factor (NGF) and its receptors are increasingly implicated in cancer progression, but their expression in cervical cancer is unclear. The objective of this study was to define the protein expression of NGF, its precursor (proNGF), as well as
Sam Faulkner, Nathan Griffin, Christopher W. Rowe, Phillip Jobling, Janine M. Lombard, Sonia M. Oliveira, Marjorie M. Walker, Hubert Hondermarck   +7 more
doaj   +1 more source

TrkA glycosylation regulates receptor localization and activity

Journal of Neurobiology, 1999
The human nerve growth factor receptor (TrkA) contains four potential N-glycosylation sites that are highly conserved within the Trk family of neurotrophin receptors, and nine additional sites that are less well conserved. Using a microscale deglycosylation assay, we show here that both conserved and variable N-glycosylation sites are used during ...
Watson, F. L., Porcionatto, Marimelia Aparecida UNIFESP, Bhattacharyya, A., Stiles, C. D., Segal, R. A.   +4 more
openaire   +2 more sources

Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling

eLife, 2018
The development of neurons in the peripheral nervous system is dependent on target-derived, long-range retrograde neurotrophic factor signals. The prevailing view is that target-derived nerve growth factor (NGF), the prototypical neurotrophin, and its ...
Mengchen Ye, Kathryn M Lehigh, David D Ginty   +2 more
doaj   +1 more source