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TrkA is necessary for the normal development of the murine thymus

Journal of Neuroimmunology, 2000
Nerve growth factor (NGF) and its signal-transducing receptor TrkA are expressed in the thymus. However, their possible role during thymic organogenesis is unknown. Here we analyze the thymus of trkA-kinase deficient 2-week-old mice. trkA-kinase +/+ and +/- mice had a normal thymus, whereas the thymus of trkA-kinase -/- mice showed lack of delimitation
Antonino M Germanà
exaly +4 more sources

Nerve growth factor & TrkA as novel therapeutic targets in cancer

Biochimica Et Biophysica Acta: Reviews on Cancer, 2016
I Ekin Demir, Güralp Onur Ceyhan
exaly

ProNGF, but Not NGF, Switches from Neurotrophic to Apoptotic Activity in Response to Reductions in TrkA Receptor Levels

International Journal of Molecular Sciences, 2017
Margaret Fahnestock
exaly

Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3)

Journal of Biological Chemistry, 2016
Carlos Martín-Rodriguez +2 more
exaly

Osteoarthritis and Cartilage, 2019
Fiona E Watt
exaly

The TPM3‐NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition

Molecular Oncology, 2014
Roberta Bosotti, Alessio Somaschini, Laura Raddrizzani +2 more
exaly

TrkA Receptor Endolysosomal Degradation is Both Ubiquitin and Proteasome Dependent

Traffic, 2008
Thangiah Geetha
exaly

Brn3a and Klf7 cooperate to control TrkA expression in sensory neurons