Results 21 to 30 of about 5,304 (178)

Effect of Synthetic Cell-Penetrating Peptides on TrkA Activity in PC12 Cells

Journal of Pharmacological Sciences, 2008
As TrkA, a high-affinity receptor of nerve growth factor (NGF), is a potential target for relieving uncontrolled inflammatory pain, an effective inhibitor of TrkA has been required for pain management.
Munetaka Hirose, Mayumi Takatori, Yoshihiro Kuroda, Mineo Abe, Eri Murata, Tetsuro Isada, Koyo Ueda, Kenji Shigemi, Masayuki Shibazaki, Fumihiro Shimizu, Masashi Hirata, Keita Fukazawa, Masahiro Sakaguchi, Kyoko Kageyama, Yoshifumi Tanaka   +14 more
doaj   +1 more source

Mouse embryonic stem cells as a discovery tool in neurobiology [PDF]

, 2012
Mouse ES cells can recapitulate, under suitable tissue culture conditions, early events in neurogenesis. As wildtype or genetically modified ES cells can be grown in unlimited quantities, their differentiation into neurons represents an attractive model
Nikoletopoulou, Vassiliki
core   +1 more source

Trypanosoma cruzi coaxes cardiac fibroblasts into preventing cardiomyocyte death by activating nerve growth factor receptor TrkA. [PDF]

PLoS ONE, 2013
Cardiomyocytes express neurotrophin receptor TrkA that promotes survival following nerve growth factor (NGF) ligation. Whether TrkA also resides in cardiac fibroblasts (CFs) and underlies cardioprotection is unknown.To test whether CFs express TrkA that ...
Daniel Aridgides, Ryan Salvador, Mercio PereiraPerrin   +2 more
doaj   +1 more source

TrkA alternative splicing [PDF]

Cancer Cell, 2004
n ...
Tacconelli, Antonella, Farina, Antonietta R., Cappabianca, Lucia, DeSantis, Giuseppina, Tessitore, Alessandra, Vetuschi, Antonella, Sferra, Roberta, Rucci, Nadia, Argenti, Beatrice, Screpanti, Isabella, Gulino, Alberto, Mackay, Andrew R.   +11 more
openaire   +2 more sources

GM1 promotes TrkA-mediated neuroblastoma cell differentiation by occupying a plasma membrane domain different from TrkA [PDF]

, 2019
Recently, we highlighted that the ganglioside GM1 promotes neuroblastoma cells differentiation by activating the TrkA receptor through the formation of a TrkA–GM1 oligosaccharide complex at the cell surface.
Sandro Sonnino, Elena Chiricozzi, Chiricozzi, Elena, Maggioni, Margherita, Nicoletta Loberto, Mauri, Laura, Margherita Maggioni, Casellato, Riccardo, Giulia Lunghi, Loberto, Nicoletta, Biase, Erika Di, Laura Mauri, Riccardo Casellato, Lunghi, Giulia, Fazzari, Maria, Sonnino, Sandro, Erika Di Biase, Diego Yuri Pomè, Pomè, Diego Yuri, Maria Fazzari   +19 more
core   +1 more source

In vivo function of NGF/TrkA signaling in the cholinergic neurons of the murine basal forebrain [PDF]

, 2005
The neurotrophins are a family of secreted proteins that potently regulate diverse neuronal responses. The neurotrophin nerve growth factor (NGF) and its receptors TrkA and p75 are well characterized to control survival, differentiation and function of ...
Mueller, Markus
core   +1 more source

Enhanced TrkA signaling impairs basal forebrain-dependent behavior

Frontiers in Molecular Neuroscience, 2023
Basal forebrain cholinergic neurons (BFCNs) modulate cognitive functions such as attention, learning and memory. The NGF/TrkA pathway plays an important role in the development and function of BFCNs, although two mouse models conditionally deleting TrkA ...
Laura Calvo-Enrique, Laura Calvo-Enrique, Silvia Lisa, Silvia Lisa, Cristina Vicente-García, Cristina Vicente-García, Ruben Deogracias, Ruben Deogracias, Juan Carlos Arévalo, Juan Carlos Arévalo   +9 more
doaj   +1 more source

Identification and characterization of the Cucurbitacins, a novel class of small-molecule inhibitors of Tropomyosin receptor kinase a

BMC Complementary and Alternative Medicine, 2019
Background NGF-TrkA is well known to play a key role in propagating and sustaining pruritogenic signals, which form the pathology of chronic pruritus. Inhibition of NGF-TrkA is a known strategy for the treatment of pruritus.
Yueling Zhong, Hong Xu, Yi Zhong, Xuemiao Zhang, Ting Zeng, Limei Li, Gaojie Xu, Minhui Li, Jin Liu, Tai Yang   +9 more
doaj   +1 more source

Physical mapping of the K+ transport trkA gene of Escherichia coli and overproduction of the TrkA protein [PDF]

Journal of Bacteriology, 1987
The position on the Escherichia coli chromosome of trkA, a gene coding for a membrane protein involved in K+ transport by the constitutive uptake system Trk, was determined. We observed that the gene is transcribed in a clockwise direction and that it is located at 72.4 min on the chromosome in a 1.75-kilobase NruI-EcoRV DNA fragment 1.0 kilobase ...
A, Hamann, D, Bossemeyer, E P, Bakker
openaire   +2 more sources

Umbilical mesenchymal stem cell-derived exosomes facilitate spinal cord functional recovery through the miR-199a-3p/145-5p-mediated NGF/TrkA signaling pathway in rats

Stem Cell Research & Therapy, 2021
Background Although exosomes, as byproducts of human umbilical cord mesenchymal stem cells (hUC-MSCs), have been demonstrated to be an effective therapy for traumatic spinal cord injury (SCI), their mechanism of action remains unclear.
Yang Wang, Xunwei Lai, Depeng Wu, Bin Liu, Nanxiang Wang, Limin Rong   +5 more
doaj   +1 more source