Enhanced TrkA signaling impairs basal forebrain-dependent behavior
Frontiers in Molecular Neuroscience, 2023 Basal forebrain cholinergic neurons (BFCNs) modulate cognitive functions such as attention, learning and memory. The NGF/TrkA pathway plays an important role in the development and function of BFCNs, although two mouse models conditionally deleting TrkA ...
Laura Calvo-Enrique +9 more
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Trophic and neurotrophic factors in human pituitary adenomas (Review) [PDF]
, 2017 The pituitary gland is an organ that functionally connects the hypothalamus with the peripheral organs. The pituitary gland is an important regulator of body homeostasis during development, stress, and other processes.
Agostinelli, Enzo +11 more
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Physical mapping of the K+ transport trkA gene of Escherichia coli and overproduction of the TrkA protein [PDF]
Journal of Bacteriology, 1987 The position on the Escherichia coli chromosome of trkA, a gene coding for a membrane protein involved in K+ transport by the constitutive uptake system Trk, was determined. We observed that the gene is transcribed in a clockwise direction and that it is located at 72.4 min on the chromosome in a 1.75-kilobase NruI-EcoRV DNA fragment 1.0 kilobase ...
A, Hamann, D, Bossemeyer, E P, Bakker
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Non-Aβ-dependent factors associated with global cognitive and physical function in alzheimer's disease: a pilot multivariate analysis [PDF]
, 2019 Recent literature highlights the importance of identifying factors associated with mild cognitive impairment (MCI) and Alzheimer's Disease (AD).
Di Baldassarre, Angela +14 more
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Trypanosoma cruzi coaxes cardiac fibroblasts into preventing cardiomyocyte death by activating nerve growth factor receptor TrkA. [PDF]
PLoS ONE, 2013 Cardiomyocytes express neurotrophin receptor TrkA that promotes survival following nerve growth factor (NGF) ligation. Whether TrkA also resides in cardiac fibroblasts (CFs) and underlies cardioprotection is unknown.To test whether CFs express TrkA that ...
Daniel Aridgides +2 more
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Target-derived neurotrophic factors regulate the death of developing forebrain neurons after a change in their trophic requirements [PDF]
, 2001 Many neurons die as the normal brain develops. How this is regulated and whether the mechanism involves neurotrophic molecules from target cells are unknown.
Asavaritikrai, P +3 more
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BMC Complementary and Alternative Medicine, 2019 Background NGF-TrkA is well known to play a key role in propagating and sustaining pruritogenic signals, which form the pathology of chronic pruritus. Inhibition of NGF-TrkA is a known strategy for the treatment of pruritus.
Yueling Zhong +9 more
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Modulation of sensory neuron mechanotransduction by PKC- and nerve growth factor-dependent pathways [PDF]
, 2006 Many sensations of pain are evoked by mechanical stimuli, and in inflammatory conditions, sensitivity to such stimuli is commonly increased. Here we used cultured sensory neurons as a model of the peripheral terminal to investigate the effects of ...
DI CASTRO, MARIA AMALIA +3 more
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Cells, 2022 The Nerve Growth Factor (NGF) belongs to the neurothrophins protein family involved in the survival of neurons in the nervous system. The interaction of NGF with its high-affinity receptor TrkA mediates different cellular pathways related to Alzheimer’s ...
Serena Vittorio +6 more
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TrkA Bumps into Its Future Self [PDF]
Developmental Cell, 2017 In neurons, correct targeting of receptors to the axon is critical for cell survival and circuit formation. In this issue of Developmental Cell, Yamashita et al. (2017) report that the ER-resident phosphatase PTP1B is required to prime TrkA for axonal transport.
Kelly, Barford +3 more
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