Results 1 to 10 of about 94,176 (342)

Postmortem Analysis in a Clinical Trial of AAV2-NGF Gene Therapy for Alzheimer's Disease Identifies a Need for Improved Vector Delivery

Human Gene Therapy, 2020
Nerve growth factor (NGF) gene therapy rescues and stimulates cholinergic neurons, which degenerate in Alzheimer's disease (AD). In a recent clinical trial for AD, intraparenchymal adeno-associated virus serotype 2 (AAV2)-NGF delivery was safe but did ...
Michael J Castle, Fernando C Baltanás, Mark Tuszyński   +2 more
exaly   +2 more sources

BUILD AN EFFECTIVE DEEP LEARNING MODEL FOR UNDERWATER IMAGE ENHANCEMENT BASED ON EUVP DATA [PDF]

ICTACT Journal on Soft Computing, 2023
Images taken underwater often suffer from colour distortion as well as a reduction in visibility because of the light absorption and scattering that occurs. Existing approaches for underwater image enhancement make use of numerous assumptions/constraints
Sugandha Jaitly, Sudha Bhati
doaj   +1 more source

Investigation of the association between cardio-metabolic risk factors, neurotrophins and gastric hormones among apparently healthy women: A cross-sectional analysis [PDF]

Journal of Cardiovascular and Thoracic Research, 2022
Introduction: Although, some evidence has shown that obestatin, ghrelin, and neurotrophic factors can be involved in the development of cardio-metabolic risk factors, there are some contradictions in this regard.
Reihaneh Zeinalian, Dorsa Arman Moghadam, Naseh Pahlavani, Neda Roshanravan, Mohammad Alizadeh, Masoumeh Jabbari, Sorayya Kheirouri   +6 more
doaj   +1 more source

Electroacupuncture Increases the Expression of Gas7 and NGF in the Prefrontal Cortex of Male Rats with Focal Cerebral Ischemia

Journal of Integrative Neuroscience, 2023
Objective: To investigate the potential mechanisms underlying the migration of endogenous neural stem cells (eNSCs) to the frontal cortex to differentiate into neurons, and to monitor the effect of electroacupuncture (EA) regulation of focal cerebral ...
Tongjun Ma, Wenqing Dong, Yegui Zhang, Jian Ding, Feng Wu   +4 more
doaj   +1 more source

The influence of electronic acupuncture at a specific frequency in facilitating the passage of NGF through the blood-brain barrier and its effect on learning and memory in MCAO/R rats

Journal of Integrative Neuroscience, 2022
Background: The blood-brain barrier (BBB) maintains the balance of the internal environment of the brain and strictly controls substance exchange between the brain and blood dynamically but stably. Transient increases in the permeability of the BBB plays
Yibin Zhao, Xuqing Mao, Hao Wang, Lin Gan, Shanshan Zhang, Peng Gong, Xianming Lin   +6 more
doaj   +1 more source

NGF activates NFAT via the MEK1/2 pathway in PC12 cells

All Life, 2022
Nerve growth factor (NGF) plays a key role in controlling growth, maintenance and survival of neurons as well as nociceptor development. Many of its critical actions are believed to be mediated by activation of corresponding transcription factors. Here I
Man Su Kim
doaj   +1 more source

Comparison of next-generation sequencing (NGS) and next-generation flow (NGF) for minimal residual disease (MRD) assessment in multiple myeloma

Blood Cancer Journal, 2020
Detecting persistent minimal residual disease (MRD) allows the identification of patients with an increased risk of relapse and death. In this study, we have evaluated MRD 3 months after transplantation in 106 myeloma patients using a commercial next ...
A. Medina, N. Puig, J. Flores-Montero, C. Jiménez, M. Sarasquete, M. García-Álvarez, Isabel Prieto-Conde, C. Chillón, M. Alcoceba, N. Gutiérrez, A. Oriol, L. Rosiñol, J. Bladé, M. Gironella, M. Hernandez, V. González-Calle, M. Cedena, B. Paiva, J. San-Miguel, J. Lahuerta, M. Mateos, J. Martínez-López, A. Órfão, Marcos González, R. García-Sanz   +24 more
semanticscholar   +1 more source

Three-Dimensional Model of Dorsal Root Ganglion Explant as a Method of Studying Neurotrophic Factors in Regenerative Medicine

Biomedicines, 2020
Neurotrophiс factors play a key role in the development, differentiation, and survival of neurons and nerve regeneration. In the present study, we evaluated the effect of certain neurotrophic factors (NGF, BDNF, and GDNF) on axon growth and migration of ...
Polina Klimovich, Kseniya Rubina, Veronika Sysoeva, Ekaterina Semina   +3 more
doaj   +1 more source

Effect of nerve growth factor dimeric mimetic GK-2 on microcirculation in skeletal muscle on the hind limb ischemia model in rats

Фармакокинетика и Фармакодинамика, 2021
The purpose of the study. In experiments on a hind limb ischemia model in rats, the effect of the TrkA-receptor agonist of the NGF 4th loop dimeric dipeptide mimetic compound GK-2 has been studied on microcirculation in ischemic skeletal muscle.Methods ...
I. B. Tsorin, A. O. Efimova, E. S. Pekeldina, M. B. Vititnova, S. A. Kryzhanovskii   +4 more
doaj   +1 more source

Cdk5 activation promotes Cos-7 cells transition towards neuronal-like cells

Translational Neuroscience, 2023
Cyclin-dependent kinase 5 (Cdk5) activity is specifically active in neurogenesis, and Cdk5 and neocortical neurons migration related biomarker are expressed in Cos-7 cells.
Bao Li, Lan Xiao-Mei, Zhang Guo-Qing, Bao Xi, Li Bo, Ma Dan-Na, Luo Hong-Yan, Cao Shi-Lu, Liu Shun-Yao, Jing E, Zhang Jian-Zhong, Zheng Ya-Li   +11 more
doaj   +1 more source