Results 11 to 20 of about 94,176 (342)
Transfection with trk restores "slow" NGF binding, efficient NGF uptake, and multiple NGF responses to NGF-nonresponsive PC12 cell mutants [PDF]
The Journal of Neuroscience, 1993 NGF binds to and activates the protein tyrosine kinase gp 140prototrk. Expression of this receptor is required for at least some responses to NGF. Three outstanding issues are addressed in the present work. First, we determined whether expression of gp 140prototrk is required for all neuronal NGF responses.
D M, Loeb, L A, Greene
openaire +3 more sources
Clinical Medicine Insights: Pathology, 2013 Despite the devastating effect of suicide on numerous lives, there is still a lack of knowledge concerning its neurochemical aspects. There is increasing evidence that brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are involved in
R. Banerjee +4 more
semanticscholar +2 more sources
NGF steers microglia toward a neuroprotective phenotype
Glia, 2018 Microglia are the sentinels of the brain but a clear understanding of the factors that modulate their activation in physiological and pathological conditions is still lacking.
C. Rizzi +11 more
semanticscholar +2 more sources
NGF-promoted axon growth and target innervation requires GITRL-GITR signaling.
, 2013 Nerve growth factor (NGF) has an important role in regulating sympathetic neuron survival and target field innervation during development. Here we show that glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR), a member of the TNF
Gerard W. O'Keeffe (14044810) +4 more
core +5 more sources
Zika Virus Enters Soma of Neuron through NGF/TrkA-Like Endosomal Signaling Pathway [PDF]
, 2021 Infection with the Zika virus results in severe neurological disease in adults or congenital Zika syndrome in newborns. We employed the domain search strategy to study the Zika virus glycoprotein E in this work.
wenzhong, liu, hualan, li
core +1 more source
Фармакокинетика и Фармакодинамика, 2023 Article describes results of study of antitumor and antimetastatic action of dipeptide mimetic of the nerve growth factor amide N-monosuccinyl-L-glutamyl-L-lysine (compound GK-1) in comparison with gemcitabine. Two injections of gemcitabine in total dose
L. P. Kovalenko +3 more
doaj +1 more source
Innovative Therapy for Alzheimer’s Disease-With Focus on Biodelivery of NGF
Frontiers in Neuroscience, 2019 Alzheimer’s disease (AD) is a progressive neurodegenerative disorder associated with abnormal protein modification, inflammation and memory impairment. Aggregated amyloid beta (Aβ) and phosphorylated tau proteins are medical diagnostic features.
Sumonto Mitra +2 more
semanticscholar +1 more source
NGF and Its Receptors in the Regulation of Inflammatory Response
International Journal of Molecular Sciences, 2017 There is growing interest in the complex relationship between the nervous and immune systems and how its alteration can affect homeostasis and result in the development of inflammatory diseases.
G. Minnone +2 more
semanticscholar +1 more source
The Role of DHEA, NGF, and ADAMTS5 Pathways in Osteoarthritis and Current Developments
Bagcilar Medical Bulletin, 2023 Degenerative joint disease is a condition that affects joints and is commonly referred to as osteoarthritis (OA). This form of arthritis is most prevalent among women and tends to become more frequent as people age.
Duygu Sarı Ak +5 more
doaj +1 more source
The Brain NGF Metabolic Pathway in Health and in Alzheimer’s Pathology
Frontiers in Neuroscience, 2019 Emerging research has re-emphasized the role of the cortical cholinergic system in the symptomology and progression of Alzheimer’s disease (AD). Basal forebrain (BF) cholinergic nuclei depend on target-derived NGF for survival during development and for ...
A. Cuello, R. Pentz, Hélène Hall
semanticscholar +1 more source