Results 21 to 30 of about 137,103 (391)
NGF steers microglia toward a neuroprotective phenotype
Glia, 2018 Microglia are the sentinels of the brain but a clear understanding of the factors that modulate their activation in physiological and pathological conditions is still lacking.
C. Rizzi +11 more
semanticscholar +1 more source
Current Issues in Pharmacy and Medical Sciences, 2020 Ulcers and slow wound healing are common in diabetic polyneuropathy (DP), as well as shooting or burning pain, sensitivity to touch or lack of sensitivity, low oxygenation of nerve tissue, conductivity disorders and various vascular disorders.
Nikitina Nataliia +6 more
doaj +1 more source
Cell Reports, 2016 SUMMARY Developing tissues dictate the amount and type of innervation they require by secreting neurotrophins, which promote neuronal survival by activating distinct tyrosine kinase receptors.
R. Tomlinson +11 more
semanticscholar +1 more source
Modulation of sensory neuron mechanotransduction by PKC- and nerve growth factor-dependent pathways [PDF]
, 2006 Many sensations of pain are evoked by mechanical stimuli, and in inflammatory conditions, sensitivity to such stimuli is commonly increased. Here we used cultured sensory neurons as a model of the peripheral terminal to investigate the effects of ...
DI CASTRO, MARIA AMALIA +3 more
core +1 more source
Nerve growth factor, brain-derived neurotrophic factor, and the chronobiology of mood: a new insight into the "neurotrophic hypothesis" [PDF]
, 2015 The light information pathways and their relationship with the body rhythms have generated a new insight into the neurobiology and the neurobehavioral sciences, as well as into the clinical approaches to human diseases associated with disruption of ...
IANNITELLI, ANGELA +2 more
core +2 more sources
A novel anti-NGF PEGylated Fab’ provides analgesia with lower risk of adverse effects
mAbs, 2023 Nerve growth factor (NGF) has emerged as a key driver of pain perception in several chronic pain conditions, including osteoarthritis (OA), and plays an important role in the generation and survival of neurons.
Yukari Koya +8 more
doaj +1 more source
Involvement of ras p2I in Neurotrophin-induced Response of Sensory, but Not Sympathetic Neurons [PDF]
, 1993 Little is known about the signal transduction mechanisms involved in the response to neurotrophins and other neurotrophic factors in neurons, beyond the activation of the tyrosine kinase activity of the neurotrophin receptors belonging to the trk family.
Barde, Y. A. +4 more
core +3 more sources
Zhongliu Fangzhi Yanjiu, 2018 Objective To evaluate the potential association of nerve growth factor (NGF) and its receptors TrkA and p75NRT with perineural invasion(PNI) and other clinicopathological features of early-stage cervical cancer.
LONG Ying +5 more
doaj +1 more source
Transfection with trk restores "slow" NGF binding, efficient NGF uptake, and multiple NGF responses to NGF-nonresponsive PC12 cell mutants [PDF]
The Journal of Neuroscience, 1993 NGF binds to and activates the protein tyrosine kinase gp 140prototrk. Expression of this receptor is required for at least some responses to NGF. Three outstanding issues are addressed in the present work. First, we determined whether expression of gp 140prototrk is required for all neuronal NGF responses.
D M, Loeb, L A, Greene
openaire +2 more sources
The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease.
Aging and Disease, 2015 Aging is a normal physiological process accompanied by cognitive decline. This aging process has been the primary risk factor for development of aging-related diseases such as Alzheimer's disease (AD).
J. Budni +4 more
semanticscholar +1 more source