Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles
Scientific Reports, 2023 Proper wiring of the peripheral nervous system relies on neurotrophic signaling via nerve growth factor (NGF). NGF secreted by target organs (i.e. eye) binds to the TrkA receptor expressed on the distal axons of postganglionic neurons. Upon binding, TrkA
Ashley J. Mason +4 more
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TrkA inhibition alleviates bladder overactivity in cyclophosphamide-induced cystitis by targeting hyperpolarization-activated cyclic nucleotide-gated channels [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): To investigate the potential of Tropomyosin receptor kinase A (TrkA) for the treatment of interstitial cystitis/ bladder pain syndrome (IC/BPS).Materials and Methods: Sixty-four female rats were randomly assigned to the control and ...
Qian Liu +4 more
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NGF, TrkA-P and neuroprotection after a hypoxic event in the developing central nervous system [PDF]
, 2018 A decrease in the concentration of oxygen in the blood and tissues (hypoxia) produces important, sometimes irreversible, damages in the central nervous system (CNS) both during development and also postnatally.
Bogetti, María Eugenia +4 more
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ProNGF-p75NTR axis plays a proinflammatory role in inflamed joints. A novel pathogenic mechanism in chronic arthritis [PDF]
, 2017 To identify the role of mature nerve growth factor (mNGF), its immature form proNGF and their receptors in arthritis ...
Benedetti, Fabrizio De +9 more
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TrkA alternative splicing [PDF]
Cancer Cell, 2004 n ...
Tacconelli, Antonella +11 more
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Effect of Synthetic Cell-Penetrating Peptides on TrkA Activity in PC12 Cells
Journal of Pharmacological Sciences, 2008 As TrkA, a high-affinity receptor of nerve growth factor (NGF), is a potential target for relieving uncontrolled inflammatory pain, an effective inhibitor of TrkA has been required for pain management.
Munetaka Hirose +14 more
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Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes c-fiber nociceptors with broad action potentials and high nav1.9 expression [PDF]
, 2006 Binding to isolectin-B4 (IB4) and expression of tyrosine kinase A (trkA) (the high-affinity NGF receptor) have been used to define two different subgroups of nociceptive small dorsal root ganglion (DRG) neurons. We previously showed that only nociceptors
Berry, Carol +6 more
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The Trk Potassium Transporter Is Required for RsmB-Mediated Activation of Virulence in the Phytopathogen Pectobacterium wasabiae [PDF]
, 2015 Pectobacterium wasabiae (previously known as Erwinia carotovora) is an important plant pathogen that regulates the production of plant cell wall-degrading enzymes through an N-acyl homoserine lactone-based quorum sensing system and through the GacS/GacA ...
Valente, Rita S., Xavier, Karina Bivar
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Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches [PDF]
, 2011 Glycosaminoglycan polysaccharides play critical roles in many cellular processes, ranging from viral invasion and angiogenesis to spinal cord injury.
Bothwell +39 more
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Stem Cell Research & Therapy, 2021 Background Although exosomes, as byproducts of human umbilical cord mesenchymal stem cells (hUC-MSCs), have been demonstrated to be an effective therapy for traumatic spinal cord injury (SCI), their mechanism of action remains unclear.
Yang Wang +5 more
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