Results 11 to 20 of about 34,671 (227)
Unveiling the TrkA-p35/CDK5 axis: a novel therapeutic target in diabetic kidney disease [PDF]
Frontiers in EndocrinologyObjectiveTo investigate the potential crosstalk between TrkA, the high-affinity nerve growth factor receptor (NGFR), and cyclin-dependent kinase 5 (CDK5) in the pathogenesis of diabetic kidney disease (DKD).
Wenbo Xia +10 more
doaj +2 more sources
The Receptor Tyrosine Kinase TrkA Is Increased and Targetable in HER2-Positive Breast Cancer
Biomolecules, 2020 The tyrosine kinase receptor A (NTRK1/TrkA) is increasingly regarded as a therapeutic target in oncology. In breast cancer, TrkA contributes to metastasis but the clinicopathological significance remains unclear.
Nathan Griffin +2 more
exaly +3 more sources
Discovery of a Proteolysis Targeting Chimera for TRKA and RET-derived oncoproteins [PDF]
Scientific ReportsWe designed Proteolysis Targeting Chimeras (PROTACs) to target Tropomyosin Receptor Kinase A (TRKA) and Rearranged during Transfection (RET) oncogenic proteins.
Marialuisa Moccia +7 more
doaj +2 more sources
TrkA activation sustains chemotherapy resistance in chemotolerant medulloblastoma cells [PDF]
Acta Neuropathologica CommunicationsMedulloblastoma (MB), one of the most common pediatric brain tumors, is reported to resist treatments in almost 30% of cases, allowing for the emergence of fatal recurrences.
Lorenzo Manfreda +6 more
doaj +2 more sources
APP is Phosphorylated by TrkA and Regulates NGF/TrkA Signaling [PDF]
The Journal of Neuroscience, 2011 The pathogenic model of Alzheimer's disease (AD) posits that aggregates of amyloid β, a product of amyloid precursor protein (APP) processing, cause dementia. However, alterations of normal APP functions could contribute to AD pathogenesis, and it is therefore important to understand the role of APP.
Matrone C +8 more
openaire +6 more sources
NGF activates NFAT via the MEK1/2 pathway in PC12 cells
All Life, 2022 Nerve growth factor (NGF) plays a key role in controlling growth, maintenance and survival of neurons as well as nociceptor development. Many of its critical actions are believed to be mediated by activation of corresponding transcription factors. Here I
Man Su Kim
doaj +1 more source
TrkA Co-Receptors: The Janus Face of TrkA?
Cancers, 2023 Larotrectinib and Entrectinib are specific pan-Trk tyrosine kinase inhibitors (TKIs) approved by the Food and Drug Administration (FDA) in 2018 for cancers with an NTRK fusion. Despite initial enthusiasm for these compounds, the French agency (HAS) recently reported their lack of efficacy. In addition, primary and secondary resistance to these TKIs has
Sarah Trouvilliez +2 more
openaire +3 more sources
Cells, 2023 Post-therapeutic relapse, poor survival rates and increasing incidence justify the search for novel therapeutic targets and strategies in cutaneous malignant melanoma (CMM).
Lucia Cappabianca +14 more
doaj +1 more source
PLoS Pathogens, 2022 Influenza A virus (IAV) infection causes acute respiratory disease with potential severe and deadly complications. Viral pathogenesis is not only due to the direct cytopathic effect of viral infections but also to the exacerbated host inflammatory ...
Vikram Verma +6 more
doaj +1 more source
Optical Activation of TrkA Signaling [PDF]
ACS Synthetic Biology, 2018 Abstract Nerve growth factor/tropomyosin receptor kinase A (NGF/TrkA) signaling plays a key role in neuronal development, function, survival, and growth. The pathway is implicated in neurodegenerative disorders including Alzheimer’s disease, chronic pain, inflammation, and cancer. NGF binds the extracellular domain of
Liting Duan +7 more
openaire +3 more sources