Results 61 to 70 of about 5,304 (178)

Progress in the Role of Mast Cells and Biomolecular Signals in the Mechanism of Postoperative Ileus: From Cellular Activation to Exploration of the Brain–Gut Axis

Gut Medicine, EarlyView.
ABSTRACT Postoperative ileus (POI) is a frequent complication after surgical procedures, predominantly manifesting as aberrant gastrointestinal motility, which markedly extends the duration of postoperative recovery for patients. The clinical duration of POI is typically modulated by intricate inflammatory cascades, with mast cells assuming a critical ...
Tian‐le Zhang, Miao‐ying Geng, Ming‐yue Shao, Gang Wang, Zhi‐wei Jiang   +4 more
wiley   +1 more source

Clostridium perfringens Alpha-Toxin Induces Gm1a Clustering and Trka Phosphorylation in the Host Cell Membrane.

PLoS ONE, 2015
Clostridium perfringens alpha-toxin elicits various immune responses such as the release of cytokines, chemokines, and superoxide via the GM1a/TrkA complex.
Teruhisa Takagishi, Masataka Oda, Michiko Kabura, Mie Kurosawa, Kaori Tominaga, Shiori Urano, Yoshibumi Ueda, Keiko Kobayashi, Toshihide Kobayashi, Jun Sakurai, Yutaka Terao, Masahiro Nagahama   +11 more
doaj   +1 more source

TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential

Nature Communications, 2020
TrkH is a bacterial ion channel that is regulated by nucleotides and its associated protein TrkA. Here the authors present ADP and ATP bound TrkH-TrkA structures, which reveal the mechanism for the transmission of nucleotide-induced conformational ...
Hanzhi Zhang, Yaping Pan, Liya Hu, M. Ashley Hudson, Katrina S. Hofstetter, Zhichun Xu, Mingqiang Rong, Zhao Wang, B. V. Venkataram Prasad, Steve W. Lockless, Wah Chiu, Ming Zhou   +11 more
doaj   +1 more source

Plasma and Synovial Fluid VEGF‐A and Neuropilin‐1 in Knee Osteoarthritis: Associations With Radiographic Severity, Pain Sensitization‐Related Features, and Disease Burden

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to investigate associations of plasma and synovial fluid vascular endothelial growth factor A (VEGF‐A) and neuropilin‐1 (NRP1) levels with radiographic severity, pain sensitization‐related features, and disease burden in knee osteoarthritis (KOA). Plasma VEGF‐A and NRP1 were measured by sandwich ELISA in 120 patients with KOA (
Cheng‐Ju Tan
wiley   +1 more source

Nerve growth factor and Tropomyosin receptor kinase A are increased in the gastric mucosa of patients with functional dyspepsia

BMC Gastroenterology, 2019
Background Nerve growth factor (NGF) and enteric glial cells (EGCs) are associated with visceral hypersensitivity and gastrointestinal motility disorder, which may represent the pathogenesis of functional dyspepsia (FD).
Haitao Shi, Shanshan Zhu, Bin Qin, Lianli Wang, Juan Yang, Guolong Lu, Fei Dai   +6 more
doaj   +1 more source

Nogo-p4 Suppresses TrkA Signaling Induced by Low Concentrations of Nerve Growth Factor Through NgR1 in Differentiated PC12 Cells

Neurosignals, 2016
Background: Regeneration of injured axons in adult mammalian central nervous system (CNS) is not spontaneous. Nogo is a major inhibitory molecule contributing to axon regeneration failure.
You-Ming Fan, Qing-Yuan Huang, Yin-Ai Wu, Alan R. Harvey, Qi Cui, Yu-Qi Gao   +5 more
doaj   +1 more source

SgG2 modifies NGF-TrkA signaling.

, 2015
Mouse SCG dissociated neurons were grown during 5 days in vitro (DIV). (A) Neurons were deprived of NGF for 16 h and were stimulated with NGF alone, NGF plus SgG2 or SgG2 alone during 5 min. TrkA-SgG2 interaction was analyzed by TrkA immunoprecipitation (
Jorge Rubén Cabrera (685511), Abel Viejo-Borbolla (185569), Antonio Alcamí (185579), Nadia Martinez-Martín (185571), Francisco Wandosell (1238), Soledad Blanco (185576)   +5 more
core   +1 more source

CCM2 Mediates Death Signaling by the TrkA Receptor Tyrosine Kinase [PDF]

, 2009
SummaryThe TrkA receptor tyrosine kinase is crucial for differentiation and survival of nerve-growth-factor-dependent neurons. Paradoxically, TrkA also induces cell death in pediatric tumor cells of neural origin, via an unknown mechanism.
Tcherpakov, Marianna, Mike Fainzilber, Loen M. Hansford, Harel, Liraz, Costa, Barbara, Levy, Zehava, Lee, Francis S., Milijana Vojvodic, Hansford, Loen M., Shi, Leming, Yaniv, Isaac, David R. Kaplan, Fainzilber, Mike, Vojvodic, Milijana, Eils, Roland, Andre Oberthuer, Francis S. Lee, Isaac Yaniv, Marc Zapatka, Roland Eils, Smadar Avigad, Oberthuer, Andre, Zehava Levy, Avigad, Smadar, Liraz Harel, Barbara Costa, Chen, Zhe-Yu, Leming Shi, Zapatka, Marc, Marianna Tcherpakov, Fischer, Matthias, Kaplan, David R., Zhe-Yu Chen, Brors, Benedikt, Matthias Fischer, Benedikt Brors   +35 more
core   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

Ndfip2 in TrkA-expressing sensory neurons regulates noxious mechanosensation through control of TrkA signaling and protein levels

Cell Death and Disease
Nociception, the neural process underlying pain detection, is modulated by the NGF/TrkA signaling axis. Although anti-NGF antibodies can alleviate chronic pain, their clinical application is limited by adverse effects, underscoring the need to identify ...
Daniel Cañada-García, Ana Hernández-García, Cristina Vicente-García, Jorge Valero, Maurilyn Ayon-Olivas, Sharad Kumar, Michael Sendtner, Juan Carlos Arévalo   +7 more
doaj   +1 more source