Results 71 to 80 of about 5,304 (178)
Reduced RabGEF1 expression decreases NGF-induced TrkA phosphorylation but not TrkA internalization.
, 2015 A) CMV and AS stable transfectants were stimulated by NGF (50 ng/ml) for 30 min, 1 hour, 3 hours, or 5 hours. Total cell lysates were analyzed by Western blot using anti-phospho-TrkA and anti-TrkA antibody.
Janet Kalesnikoff (828869) +4 more
core +1 more source
NTRK1/TrkA Activation Overrides the G2/M-Checkpoint upon Irradiation
, 2021 High expression of the receptor tyrosine kinase TrkA/NTRK1 is associated with a favorable outcome in several solid tumors of childhood including neuroblastoma.
Vivian Boron +6 more
core +1 more source
Sensory Neuroscience, EarlyView.Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa +5 more
wiley +1 more source
Advances in research on layered double hydroxides for biomedical applications
Smart Molecules, EarlyView.Layered double hydroxides (LDHs) are pH‐responsive nanomaterials with broad biomedical applications. This review summarizes LDH synthesis methods and compares their advantages. It highlights LDHs' progress in cancer therapy, including chemo‐photothermal, chemo‐immunotherapy, and photodynamic‐immunotherapy combinations and their potential in bone repair.
Xinhui Yang +13 more
wiley +1 more source
FASEB BioAdvances, 2020 Nerve growth factor (NGF) and its receptors are increasingly implicated in cancer progression, but their expression in cervical cancer is unclear. The objective of this study was to define the protein expression of NGF, its precursor (proNGF), as well as
Sam Faulkner +7 more
doaj +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
TrkA immunoreactivity in native human scalp skin hair follicles.
, 2019 a-TrkA, b-NKIbeteb, c-merge with Hoechst counterstaining of nuclei, d-magnified insert indicated by white box in c. A: melanocytes re-establishing the pigmentary-unit during early anagen express TrkA.
Remo Campiche (3714208) +3 more
core +1 more source
Mecanismo de activación del receptor de neurotrofinas TrkA [PDF]
, 2022 TrkA (Tropomyosin receptor kinase A) es una proteína transmembrana, miembro de la superfamilia de receptores tirosina quinasa (RTK) y receptor específico del factor de crecimiento NGF. Se ha determinado que el NGF inicia sus acciones biológicas al unirse
Franco Rivadeneira, Maria Luisa
core
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
Neuropilin-1 inhibition suppresses nerve growth factor signaling and nociception in pain models
The Journal of Clinical InvestigationNerve growth factor (NGF) monoclonal antibodies inhibit chronic pain, yet failed to gain approval due to worsened joint damage in osteoarthritis patients.
Chloe J. Peach +15 more
doaj +1 more source