Results 81 to 90 of about 34,671 (227)
Nature Communications, 2020 TrkH is a bacterial ion channel that is regulated by nucleotides and its associated protein TrkA. Here the authors present ADP and ATP bound TrkH-TrkA structures, which reveal the mechanism for the transmission of nucleotide-induced conformational ...
Hanzhi Zhang +11 more
doaj +1 more source
, 2019 To exploit the benefits of massive multiple-input multiple-output (M-MIMO) technology in scenarios where base stations (BSs) need to be cheap and equipped with simple hardware, the computational complexity of classical signal processing schemes for ...
Abrao, Taufik +2 more
core +1 more source
Alternative TrkA Splicing and Neuroblastoma
, 2012 Neuroblastoma is one of the most frequent solid paediatric tumours of the nervous system, accounting for up to 10% of all paediatric tumours. The majority of NBs originate from a sympathoadrenal cell lineage of neural crest origin during sympathetic nervous system development, and represent a heterogeneous group of tumours that exhibit a high degree of
FARINA, ANTONIETTA +7 more
openaire +3 more sources
Australian Veterinary Journal, EarlyView.Clinical scenario Canine osteoarthritis (OA) is a degenerative joint disease and is one of the most common chronic conditions in dogs and other species. The management of OA remains a longstanding focus in veterinary medicine. Traditionally, nonsteroidal anti‐inflammatory drugs (NSAIDs) have been the first‐line treatment option for canine OA. Recently,
X Yang, P Macarthur
wiley +1 more source
iScience, 2022 Summary: Neuroblastoma (NB) is the most common extracranial malignant solid tumor in children. We found that TTF1, TrkA, and miR-204 were lowly expressed, whereas TrkB was highly expressed in undifferentiated NB tissues.
Tianyou Yang +12 more
doaj +1 more source
TrkA abundance is increased in cutaneous nerves in bortezomib‐induced neuropathy
Brain Pathology, EarlyView.Cutaneous nerves in bortezomib‐induced peripheral neuropathy (BIPN) show reduced nerve fiber density, increased TrkA expression, and enhanced dermal angiogenesis, highlighting a pathological switch in NGF/TrkA signaling that may contribute to nerve damage and pain. Abstract Tropomyosin receptor kinase A (TrkA), a high‐affinity receptor for nerve growth
Yuying Jin +14 more
wiley +1 more source
How round is a protein? Exploring protein structures for globularity using conformal mapping. [PDF]
, 2014 We present a new algorithm that automatically computes a measure of the geometric difference between the surface of a protein and a round sphere. The algorithm takes as input two triangulated genus zero surfaces representing the protein and the round ...
Hass, Joel, Koehl, Patrice
core +2 more sources
TrkA Signalling and Parkinson’s Dementia
, 2022 Cognitive impairment and dementia are the most frequently occurring nonmotor symptoms in Parkinson’s disease (PD), yet these symptoms are mostly overlooked and are not diagnosed and treated exceptionally like the cardinal motor symptoms in clinical practice.
J. Jeyaram Bharathi, Justin Antony
openaire +2 more sources
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Molecular Metabolism, 2022 Objective: Brown adipogenesis and thermogenesis in brown and beige adipose tissue (AT) involve vascular remodeling and sympathetic neuronal guidance. Here, we investigated the molecular mechanism coordinating these processes.
Alexes C. Daquinag +3 more
doaj +1 more source