Results 101 to 110 of about 34,671 (227)

Neuroprotektion und Aktivierung von Neurotrophin-Signaltransduktionswegen durch Hemmung von Protein-Tyrosin-Phosphatasen und durch NO-Donatoren [PDF]

, 2004
Trotz des enormen Fortschrittes der Medizin und neuen Erkenntnissen über die pathologischen Mechanismen des neuronalen Zelltodes steht bislang keine wirkungsvolle, kausale Therapie zur Behandlung neurodegenerativer Erkrankungen zur ...
Gerling, Norbert, Krieglstein, Josef (Prof. Dr. Dr.)   +1 more
core   +1 more source

Characterization of TRKA signaling in acute myeloid leukemia [PDF]

Oncotarget, 2018
Tropomyosin-related kinase A (TRKA) translocations have oncogenic potential and have been found in rare cases of solid tumors. Accumulating evidence indicates that TRKA and its ligand, nerve growth factor (NGF), may play a role in normal hematopoiesis and may be deregulated in leukemogenesis. Here, we report a comprehensive evaluation of TRKA signaling
Herbrich, Shelley M., Kannan, Sankaranarayanan, Nolo, Riitta M., Hornbaker, Marisa, Chandra, Joya, Zweidler-McKay, Patrick A.   +5 more
openaire   +2 more sources

Hypoxia‐induced vulnerability of the somatosensory nervous system

The Journal of Physiology, EarlyView.
Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley   +1 more source

Nerve growth factor is expressed by postmitotic avian retinal horizontal cells and supports their survival during development in an autocrine mode of action. [PDF]

, 2001
Cell death in the developing retina is regulated, but so far little is known about what factors regulate the cell death. Several neurotrophic factors and receptors, including the neurotrophins and Trk receptors, are expressed during the critical time. We
Catsicas, S, Hallbook, F, Karlsson, M, Karten, H, Mayordomo, R, Reichardt, LF   +5 more
core  

Regressive Neuroblastoma: Widely Accepted, Underreported Histology

Clinical Case Reports, Volume 14, Issue 5, May 2026.
Whole‐mount section of the regressed neuroblastoma within the adrenal gland, showing a loose, collagenous, and edematous stroma. ABSTRACT Neuroblastoma accounts for approximately 8% of all pediatric cancers and up to 15% of pediatric cancer‐related deaths in malignant cases; neuroblastoma is the most common malignancy in infancy.
Tom Membrez, Jim C. H. Wilde, Oliver Sanchez, Danai Papangelopoulou, Fabienne Gumy‐Pause, Anne‐Laure Rougemont   +5 more
wiley   +1 more source

Nerve growth factor and its receptor tyrosine kinase TrkA are overexpressed in cervical squamous cell carcinoma

FASEB BioAdvances, 2020
Nerve growth factor (NGF) and its receptors are increasingly implicated in cancer progression, but their expression in cervical cancer is unclear. The objective of this study was to define the protein expression of NGF, its precursor (proNGF), as well as
Sam Faulkner, Nathan Griffin, Christopher W. Rowe, Phillip Jobling, Janine M. Lombard, Sonia M. Oliveira, Marjorie M. Walker, Hubert Hondermarck   +7 more
doaj   +1 more source

Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]

, 2016
Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui, Hellman, Judith, Schumacher, Mark   +2 more
core   +2 more sources

Expression of NGF, Trka and p75 in human cartilage

European Journal of Histochemistry, 2009
Nerve growth factor (NGF) exerts its action through two types of receptor: high-affinity tyrosine kinase A receptor (trkA) and low-affinity p75 receptor. NGF has a neurotrophic role in central and peripheral nervous system development, but there is also clear evidence of its involvement in the developing skeleton.
Gigante A., Bevilacqua C., Pagnotta A., Manzotti S., Toesca A., Greco F.   +5 more
openaire   +6 more sources

The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII

Journal of Experimental & Clinical Cancer Research, 2018
Oncogenes derived from the neurotrophin receptor tropomyosin-related kinase TrkA act as drivers in sub-populations of a wide-range of human cancers. This, combined with a recent report that both adult and childhood cancers driven by novel oncogenic TrkA ...
Antonietta Rosella Farina, Lucia Cappabianca, Pierdomenico Ruggeri, Luciana Gneo, Cristina Pellegrini, Maria-Concetta Fargnoli, Andrew Reay Mackay   +6 more
doaj   +1 more source

A Spaetzle-like role for nerve growth factor beta in vertebrate immunity to Staphylococcus aureus [PDF]

, 2014
Many key components of innate immunity to infection are shared between Drosophila and humans. However, the fly Toll ligand Spaetzle is not thought to have a vertebrate equivalent.
A. Kaser, Addis, Aloe, Aranda, Ashburner, B. Ochoa, B. Surewaard, Belvin, Bischoff, C. A. Loynes, C. Bryant, C. G. Woods, C. Klapholz, Carnesecchi, Chamy, Chen, Cohen, D. M. Grogono, de Tayrac, Floto, Floto, Guo, G  mez, Hoffmann, Howe, J. Cachat, J. Connolly, K. Brown, K. Hegyi, K. L. Hammond, Kwan, L. Hepburn, L. Minichiello, L. Wang, Lemaitre, Lowy, M. E. Torok, M. Holden, M. Otto, M. Schiebler, Mizuguchi, Murzin, N. V. Ogryzko, Needham, Novick, Otten, P. Ligoxygakis, P. Moreno, Paradis, Peschon, Prajsnar, Prajsnar, R. A. Floto, R. Antrobus, Renna, Rice, Rigby, Rotthier, S. A. Renshaw, S. J. Foster, S. J. Peacock, S. L. Seneviratne, Seidah, Shi, Sofroniew, Stuart, Surewaard, T. Blundell, T. K. Prajsnar, T. Ny, Thwaites, Valanne, Vitt, Weber, Wu, Zhu   +75 more
core   +1 more source