Results 101 to 110 of about 5,304 (178)

Nerve Growth Factor Receptor TrkA Exists as a Preformed, yet Inactive, Dimer in Living Cells [PDF]

, 2010
The tropomyosin-related kinase A (TrkA) receptor and its ligand, nerve growth factor (NGF), play crucial roles in the development and function of the nervous system.
Maruyama, Ichiro N., Ichiro N. Maruyama, Maruyama, Ichiro, Jianying Shen, Shen, Jianying   +4 more
core   +1 more source

Cancer Neuroscience: From Local Neuro–Immune Microenvironments to Systemic Brain–Body Circuitry

MedComm, Volume 7, Issue 9, September 2026.
This review outlines the cancer neuroscience paradigm, spanning systemic brain–body circuitry and local neuro–immune–tumor microenvironments. We discuss how tumors promote axonogenesis and pseudo‐synapse formation, and how sensory neuropeptides, such as CGRP, contribute to CD8+ T‐cell exhaustion.
Mingxuan Xie, Yu Zhao, Xinruo Xing, Yuqiang Liu, Jungang Zhao, Maojin Yao, Jun Tang, Jianzhu Zhao   +7 more
wiley   +1 more source

NGF signaling in PC12 cells: the cooperation of p75NTR with TrkA is needed for the activation of both mTORC2 and the PI3K signalling cascade

Biology Open, 2013
Summary PC12-27, a PC12 clone characterized by high levels of the transcription repressor REST and by very low mTORC2 activity, had been shown to be unresponsive to NGF, possibly because of its lack of the specific TrkA receptor.
Sara Negrini, Rosalba D'Alessandro, Jacopo Meldolesi   +2 more
doaj   +1 more source

Molecular Mediators Associated With Myelination, Demyelination, and Remyelination in the Peripheral Nervous System

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT The peripheral nervous system (PNS) is responsible for innervating all regions of the body outside of the central nervous system (CNS), the latter consisting of the brain, spinal cord, and optic nerves. While myelin is an essential component for the efficient functioning of both CNS and peripheral nerve cells, it is particularly important for ...
Kathleen Margaret Hagen, Shalina Sheryl Ousman   +1 more
wiley   +1 more source

Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging

Pharmaceuticals, 2019
The tropomyosin receptor kinases family (TrkA, TrkB, and TrkC) supports neuronal growth, survival, and differentiation during development, adult life, and aging.
Ralf Schirrmacher, Justin J. Bailey, Andrew V. Mossine, Peter J. H. Scott, Lena Kaiser, Peter Bartenstein, Simon Lindner, David R. Kaplan, Alexey Kostikov, Gert Fricker, Anne Mahringer, Pedro Rosa-Neto, Esther Schirrmacher, Carmen Wängler, Björn Wängler, Alexander Thiel, Jean-Paul Soucy, Vadim Bernard-Gauthier   +17 more
doaj   +1 more source

The High‐Intensity Zone: A Dynamic Inflammatory Hub in Lumbar Disc Degeneration

Orthopaedic Surgery, Volume 18, Issue 9, Page 1804-1818, September 2026.
The HIZ, a dynamic inflammatory hub in lumbar disc degeneration, links inflammation‐degeneration‐pain; integrating advanced diagnostics and targeted therapies offers precise management for discogenic low back pain. ABSTRACT The lumbar intervertebral disc high‐intensity zone (HIZ), a focal hyperintensity within the annulus fibrosus on T2‐weighted ...
Qi Zhou, Jingyi Cai, Weijian Zhu, Sirui Zhou, Liling Zhou, Yiyao Pei, Gang Wu   +6 more
wiley   +1 more source

A rich network of S100+/tropomyosin receptor kinase A+ nerve fibers in the connective tissue wall of radicular cysts: An immunohistochemical study of biopsy cases

Saudi Endodontic Journal
Introduction: Limited information is available regarding the presence of nerve fibres in human radicular granulomas and cysts. The aim of the present study was to map the neural network of human radicular cysts by the immunohistochemical expression of ...
Nikolaos P. Kerezoudis, Taxiarchis G. Kontogiannis, Konstantinos I. Tosios   +2 more
doaj   +1 more source

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies

Traffic, Volume 27, Issue 3, September 2026.
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby, Gunjan Misri, Naava Naslavsky, Steve Caplan   +3 more
wiley   +1 more source

Effects of the selective TrkA agonist gambogic amide on pigmentation and growth of human hair follicles in vitro.

PLoS ONE, 2019
The human hair follicle is a neuroendocrine mini-organ that can be used to study aging processes in vitro. Neurotrophins maintain homeostasis in hair biology via the Trk-family of receptors. TrkA, the high affinity receptor for nerve growth factor (NGF),
Remo Campiche, Maria Daniltchenko, Dominik Imfeld, Eva M J Peters   +3 more
doaj   +1 more source

Nerve growth factor & TrkA as novel therapeutic targets in cancer.

, 2016
In the past 20years, nerve growth factor (NGF) and its receptors TrkA & p75NTR were recognized to be overexpressed in the overwhelming majority of human solid cancers.
Demir, Ihsan Ekin;Tieftrunk, Elke;Schorn, Stephan;Friess, Helmut;Ceyhan, Güralp O
core   +1 more source