Results 91 to 100 of about 5,304 (178)

A De Novo Peptide That Induces Axonal Growth Through TrkB Activation

ChemBioChem, Volume 27, Issue 17, 14 September 2026.
A homodimeric anti‐TrkB macrocyclic peptide, DiTrbL3, originally discovered by the RaPID system as monomeric form, dimerizes the TrkB receptor and activate the downstream signaling. DiTrbL3 acts as a mimic of BDNF (the natural protein ligand) and stimulates hippocampal neurons to extend axons.
Rumit Maini, Kota Tamada, Kunihiro Fukuda, Toru Takumi, Hiroaki Suga   +4 more
wiley   +1 more source

Advances in Targeting Central Cholinergic Dysfunction for Neurodegenerative Diseases: From Pharmacotherapy to Neuromodulation

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review charts the evolution of cholinergic therapies for neurodegenerative diseases—from classical acetylcholinesterase inhibitors (AChEIs) providing symptomatic relief to precision multi‐target drugs and neuromodulation (VNS, DBS, NIBS) that restore dysfunctional circuits. Emerging gene therapy, cell regeneration, and advanced cholinergic imaging
Lei Lei, Xiaoyu Hu, Ruida Lu, Jian‐jun Yang, Qingsheng Meng   +4 more
wiley   +1 more source

Cancer‐related pain: A bidirectional modulator of cancer progression

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
CRP and tumour progression engage in a dynamic, bidirectional circuit mediated by multiple mechanisms involving neuroimmunology and cancer ‐neuroscience. Analgesic interventions may affect tumour progression, while anticancer therapies can influence pain. Targeting pain in cancer may have promising therapeutic value in cancer progression.
Junzhe He, Yu Zhang, Qian Liu, Biao Yan, Peiwei Chai, Renbing Jia   +5 more
wiley   +1 more source

Site-specific biotinylation of TrkA and P75NTR receptors.

, 2014
Western blot for the analysis of the biotinylation reaction in living cells of A1/S6-TrkA-EGFP (A) and A1/S6-P75NTR-EGFP constructs (B) using CoA-biotin substrate and AcpS or SfpS PPTases.
Teresa De Nadai (666478), Alessandro Viegi (161153), Mariantonietta Calvello (666480), Antonino Cattaneo (161159), Laura Marchetti (666477), Fulvio Bonsignore (666479), Fabio Beltram (193397), Giovanni Signore (193384), Stefano Luin (666481)   +8 more
core   +1 more source

Data_Sheet_1_Enhanced TrkA signaling impairs basal forebrain-dependent behavior.PDF

, 2023
Basal forebrain cholinergic neurons (BFCNs) modulate cognitive functions such as attention, learning and memory. The NGF/TrkA pathway plays an important role in the development and function of BFCNs, although two mouse models conditionally deleting TrkA ...
Ruben Deogracias, Laura Calvo-Enrique, Laura Calvo-Enrique (17024262), Cristina Vicente-García, Cristina Vicente-García (7540889), Ruben Deogracias (17024265), Juan Carlos Arévalo (17024268), Silvia Lisa, Juan Carlos Arévalo, Silvia Lisa (195205)   +9 more
core   +1 more source

Taurine and Metabolic Diseases: Molecular Mechanisms and Therapeutic Implications

Food Frontiers, Volume 7, Issue 5, September 2026.
The dietary sources of taurine, as well as its protective effects and mechanisms in metabolism‐related diseases and metabolic disorder–associated ocular and cerebral injuries. ABSTRACT Taurine (Tau) is a sulfur‐containing amino acid prevalent in animal tissues and primarily acquired through dietary sources.
Xiaojie Ma, Zhijian Rao, Lifang Zheng
wiley   +1 more source

NGF - the TrkA to successful pain treatment.

Journal of pain research, 2012
Chronic pain arising from various pathological conditions such as osteoarthritis, low back or spinal injuries, cancer, and urological chronic pelvic pain syndromes presents significant challenges in diagnosis and treatment. Specifically, since the underlying cause of these pain syndromes is unknown or heterogeneous, physicians diagnose and treat ...
Kumar, Vinayak, Mahal, Brandon
openaire   +4 more sources

Addressing Overlooked Variables in Preclinical Fracture Repair Research for Improved Translation

Journal of Orthopaedic Research, Volume 44, Issue 9, September 2026.
ABSTRACT In preclinical research focused on bone fracture repair, a significant gap exists in understanding and incorporating key variables that influence homeostasis and pathophysiological processes. Factors such as immune system responses, sex differences, pain and innervation, and microbiota are often overlooked.
Christina Capobianco, Katharina Schmidt‐Bleek, Melanie Haffner‐Luntzer, Chelsea Bahney, Joseph L. Roberts, Matthew J. Silva, Annemarie Lang   +6 more
wiley   +1 more source

Rat visual cortical neurones express TrkA NGF receptor

, 2002
In this study we report the expression of TrkA receptor within the rat visual cortex during postnatal development and in adulthood, using a specific monoclonal antibody which recognizes the extracellular domain of TrkA receptor.
COVACEUSZACH S, TROPEA D, DOMENICI L, CAPSONI, SIMONA, CATTANEO, ANTONINO, CATTANEO A.   +5 more
core   +2 more sources

A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain Via Notochordal Cell Loss and Pain‐Inducing Nucleus Pulposus Cell Emergence

JOR SPINE, Volume 9, Issue 3, September 2026.
A porcine model of disc injury recapitulates key clinical, histological, and molecular features of human discogenic low back pain. Multi‐omics analyses identify a shift from notochordal cells to pain‐associated nucleus pulposus cells as a potential driver of disease progression. ABSTRACT Background Lower back pain (LBP) is one of the most common causes
Giselle Kaneda, Jacob T. Wechsler, Melissa Chavez, Julia Sheyn, Karandeep Cheema, Chushu Shen, Dante Rigo De Righi, Lixia Wang, Yin‐Chen Hsu, Pablo Avalos, Yibin Xie, Wafa Tawackoli, Candace Floyd, Debiao Li, Dmitriy Sheyn   +14 more
wiley   +1 more source