Results 111 to 120 of about 5,304 (178)

TrkA Overexpression Enhances Growth and Metastasis of Breast Cancer Cells, and Ku86 Is Crucial for TrkA Overexpression-Induced Breast Cancer Cell Invasion.

, 2009
The Trk family of neurotrophin tyrosine kinase receptors is emerging as an important player in carcinogenic progression in non-neuronal tissues. Here, we show that breast tumors present high levels of TrkA and phospho-TrkA compared to normal breast ...
H. Hondermarck, S. Meignan, C. Tastet, C. Lagadec, E. Com, X. LeBourhis   +5 more
core   +1 more source

Interaction of Erdosteine with TrkA Signaling Pathways: Implications for Analgesia

Thiol-containing drugs may interact with a region of tropomyosin receptor kinase A (TrkA), potentially inhibiting its activation by nerve growth factor (NGF). This action has been linked to potential analgesic activities. Here, we describe the ability of
Stefano Govoni, Luda Diatchenko, Clive P. Page, Nicoletta Marchesi, Massimo Allegri, Jacopo Vertemara, Alessia Pascale, Silvia Natoli, Piercarlo Fantucci   +8 more
core   +1 more source

Structures of antagonists for TrkC or TrkA.

, 2014
Structures of antagonists for TrkC or TrkA.
Andrey Malakhov (531563), H. Uri Saragovi (53495), Kevin Burgess (531564), Eunhwa Ko (531562), Fouad Brahimi (531561)   +4 more
core   +1 more source

Regulation of TRKA expression by BEX3

, 2013
Resumen del póster presentado a l 15º Congreso Nacional de la Sociedad Española de Neurociencia (SENC) celebrado en Oviedo del 25 al 27 de septiembre de 2013.TrkA protein levels are tightly regulated during development to ensure the survival of NGF ...
Arévalo, Juan Carlos, Anta, Begoña, Martín-Zanca, Dionisio, López-Benito, Saray, Calvo, Laura   +4 more
core  

TRKA expression and NTRK1 gene copy number across solid tumours

, 2018
Aims Neurotrophic Tropomyosin Kinase Receptor 1 (NTRK1) gene encodes for the protein Tropomyosin-related kinase A (TRKA). Deregulated activity of TRKA has been shown to have oncogenic potential. We present here the results of an immunohistochemical (IHC)
Gianluca Mauri, Giulio Cerea, Patrizia Recchimuzzo, Maiolani, Martina, Rospo, Giuseppe, Silvio Veronese, Christiansen, Jason, Ivana Stella Cavenago, Emanuela Bonoldi, Michele Schirru, Alessio Amatu, Steven J Potts, Mauro Truini, Sartore-Bianchi, Andrea, Valentina Motta, Lauricella, Calogero, Bonoldi, Emanuela, Emanuele Valtorta, Giuseppe Rospo, Bonazzina, Erica Francesca, Marrapese, Giovanna, Giovanna Marrapese, Vincenzo Fiorillo, Martina Maiolani, Recchimuzzo, Patrizia, Motta, Valentina, Veronese, Silvio, Truini, Mauro, Mauri, Gianluca, Calogero Lauricella, Siena, Salvatore, Fiorillo, Vincenzo, Potts, Steven J, Cavenago, Ivana Stella, Salvatore Siena, Tosi, Federica, Federica Tosi, Jason Christiansen, Andrea Sartore-Bianchi, Valtorta, Emanuele, Erica Francesca Bonazzina, Schirru, Michele, Cerea, Giulio, Amatu, Alessio   +43 more
core   +1 more source

TrkA/TrkC and PV Immunohistochemistry in DRG and Spinal Cord

, 2013
Red represents TrkA, green represents TrkC (and PV in [C]), and yellow represents co-expression. (A) TrkA/TrkC immunostaining in E15 DRG. TrkC-positive neurons normally eliminated in NT-3 KOs are rescued in double KOs.
Reha S Erzurumlu (26742), April E Mendoza (26741), Barış Genç (26739), P. Hande Özdinler (26740)   +3 more
core   +1 more source

TrkA activation sustains chemotherapy resistance in chemotolerant medulloblastoma cells

Acta Neuropathologica Communications
Medulloblastoma (MB), one of the most common pediatric brain tumors, is reported to resist treatments in almost 30% of cases, allowing for the emergence of fatal recurrences.
Lorenzo Manfreda, Roberta Bortolozzi, Diletta Mao, Elena Mariotto, Giampietro Viola, Luca Persano, Elena Rampazzo   +6 more
doaj   +1 more source

NGF Signaling Exacerbates KOA Peripheral Hyperalgesia via the Increased TRPV1-Labeled Synovial Sensory Innervation in KOA Rats

Pain Research and Management
Objectives. Knee osteoarthritis (KOA) pain is caused by nociceptors, which are actually sensory nerve fiber endings that can detect stimuli to produce and transmit pain signals, and high levels of NGF in synovial tissue led to peripheral hyperalgesia in ...
Zixiu Liu, Mingchao Li, Li Zhang, Xiaoqing Shi, Taiyang Liao, Lishi Jie, Likai Yu, Peimin Wang   +7 more
doaj   +1 more source

Ganoderma Spore Lipids Inhibit Perineural Invasion in Pancreatic Cancer by Downregulating NGF-TrkA Pathway

Journal of Evidence-Based Integrative Medicine
Perineural invasion (PNI) is an important factor leading to the recurrence of pancreatic cancer (PanCa). The NGF–TrkA pathway is related to PNI progression. Ganoderma spore lipid (GSL) is a drug with anti-cancer properties.
Haohui Lin MS, Manhon Chung MD, Yi Yang MS, Li Zhang MS, Xiaohua Pan MD, Sa Cai MD, PhD, Yu Pan PhD   +6 more
doaj   +1 more source

Functional expression of TrkA receptors in hippocampal neurons

, 2013
Nerve growth factor (NGF) initiates its biological effects by promoting the dimerization and activation of the tyrosine kinase receptor TrkA. The requirements for NGF signaling through the TrkA receptor have been defined extensively from studies in ...
Aibel, Lani, Pérez González, Pilar, Martín-Zanca, Dionisio, Chao, Moses V.   +3 more
core   +1 more source