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TrkA ligands : development and uses
, 1997 Neurotrophins are dimeric polypeptides responsible for the survival, differentiation and maintenance of specific neuronal populations that express cell surface receptors termed tropomyosin receptor kinases (Trks). Trks possess intrinsic tyrosine kinase activity and are thought to mediate most neurotrophic effects.
LeSauteur, Lynne.
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Alternative TrkA splicing and Cancer
, 2006 The high affinity Nerve Growth Factor receptor TrkA is critical for the development, maturation and maintenance of central and peripheral nervous systems and plays an important role in immune system development and function. TrkA oncogenes exhibit spontaneous ligand-independent activity resulting from activating point mutation, deletion or somatic ...
TACCONELLI A +8 more
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Structural characterization of nonactive site, TrkA-selective kinase inhibitors
Proceedings of the National Academy of Sciences of the United States of America, 2017 Current therapies for chronic pain can have insufficient efficacy and lead to side effects, necessitating research of novel targets against pain. Although originally identified as an oncogene, Tropomyosin-related kinase A (TrkA) is linked to pain and ...
Darrell Henze +2 more
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Science's STKE, 2002
Nerve growth factor (NGF), which is a ligand for the Trk receptor tyrosine kinases, has two roles in sympathetic nerve cells: survival and differentiation. Sympathetic neurons also rely on other neurotrophins, such as members of the glial-cell line-derived nuerotrophic factor family ligands (GFLs).
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Nerve growth factor (NGF), which is a ligand for the Trk receptor tyrosine kinases, has two roles in sympathetic nerve cells: survival and differentiation. Sympathetic neurons also rely on other neurotrophins, such as members of the glial-cell line-derived nuerotrophic factor family ligands (GFLs).
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Dual association of a TRKA polymorphism with schizophrenia
Psychiatric Genetics, 2011An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with ...
Van Schijndel, Jessica E +23 more
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TrkA signal transduction pathways in neuroblastoma
Medical and Pediatric Oncology, 2001Favorable neuroblastomas frequently express high levels of the TrkA receptor, and these tumors have a propensity to either differentiate or regress, but the mechanisms responsible for these two fates are unclear.To study TrkA signal transduction in neuroblastoma (nb), we stably expressed wild-type TrkA and five TrkA mutants in the human nb cell line SH-
A, Eggert +4 more
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Cancer Research, 2016
Abstract Kinase gene fusions have been implicated as oncogenic drivers promoting cell survival and proliferation. TrkA gene fusions have been reported in a number of cancer types including lung, colorectal, papillary thyroid, sarcoma, cholangiocarcinoma and other tumors. We have identified novel, potent, selective and orally bioavailable
Vijaya G. Tirunagaru +6 more
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Abstract Kinase gene fusions have been implicated as oncogenic drivers promoting cell survival and proliferation. TrkA gene fusions have been reported in a number of cancer types including lung, colorectal, papillary thyroid, sarcoma, cholangiocarcinoma and other tumors. We have identified novel, potent, selective and orally bioavailable
Vijaya G. Tirunagaru +6 more
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Trends in Cell Biology, 2002
Nerve growth factor (NGF) is the founding member of the neurotrophins, a family of neuronal signaling molecules that are involved in mediating the differentiation and survival of neurons during formation and regeneration of the nervous system. To exert its effects, NGF binds to and activates presynaptic tyrosine kinase (Trk) receptors that convey a ...
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Nerve growth factor (NGF) is the founding member of the neurotrophins, a family of neuronal signaling molecules that are involved in mediating the differentiation and survival of neurons during formation and regeneration of the nervous system. To exert its effects, NGF binds to and activates presynaptic tyrosine kinase (Trk) receptors that convey a ...
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Science Signaling, 2001
TrkA receptors for nerve growth factor (NGF) are thought to signal not only at the plasma membrane, but also during transport in vesicles from axons to the cell body where nuclear targets are located. Lou et al . describe association of the TrkA receptor tyrosine kinase with proteins that may help coordinate such ...
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TrkA receptors for nerve growth factor (NGF) are thought to signal not only at the plasma membrane, but also during transport in vesicles from axons to the cell body where nuclear targets are located. Lou et al . describe association of the TrkA receptor tyrosine kinase with proteins that may help coordinate such ...
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2005
Enciklopedijska natuknica govori o povijesti nekadašnjeg viteškog, a danas pučkog konjaničkog natjecanja u istarskom Barbanu.
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Enciklopedijska natuknica govori o povijesti nekadašnjeg viteškog, a danas pučkog konjaničkog natjecanja u istarskom Barbanu.
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