Results 121 to 130 of about 34,671 (227)

Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging

Pharmaceuticals, 2019
The tropomyosin receptor kinases family (TrkA, TrkB, and TrkC) supports neuronal growth, survival, and differentiation during development, adult life, and aging.
Ralf Schirrmacher, Justin J. Bailey, Andrew V. Mossine, Peter J. H. Scott, Lena Kaiser, Peter Bartenstein, Simon Lindner, David R. Kaplan, Alexey Kostikov, Gert Fricker, Anne Mahringer, Pedro Rosa-Neto, Esther Schirrmacher, Carmen Wängler, Björn Wängler, Alexander Thiel, Jean-Paul Soucy, Vadim Bernard-Gauthier   +17 more
doaj   +1 more source

Subconjunctival delivery of p75NTR antagonists reduces the inflammatory, vascular, and neurodegenerative pathologies of diabetic retinopathy [PDF]

, 2017
The p75NTR is a novel therapeutic target validated in a streptozotocin mouse model of diabetic retinopathy. Intravitreal (IVT) injection of small molecule p75NTR antagonist THX-B was therapeutic and resolved the inflammatory, vascular, and ...
Barcelona, Pablo Federico, Galan, Alba, Jian, Yifan, Nedev, Hinyu, Saragovi, H. Uri, Sarunic, Marinko V.   +5 more
core   +1 more source

Amitriptyline is a TrkA and TrkB Receptor Agonist that Promotes TrkA/TrkB Heterodimerization and Has Potent Neurotrophic Activity

Chemistry & Biology, 2009
Neurotrophins, the cognate ligands for the Trk receptors, are homodimers and induce Trk dimerization through a symmetric bivalent mechanism. We report here that amitriptyline, an antidepressant drug, directly binds TrkA and TrkB and triggers their dimerization and activation.
Jang, Sung Wuk, Liu, Xia, Chan, Chi Bun, Weinshenker, David, Hall, Randy A., Xiao, Ge, Ye, Keqiang   +6 more
openaire   +4 more sources

Low Density Limit of BCS Theory and Bose-Einstein Condensation of Fermion Pairs [PDF]

, 2011
We consider the low density limit of a Fermi gas in the BCS approximation. We show that if the interaction potential allows for a two-particle bound state, the system at zero temperature is well approximated by the Gross-Pitaevskii functional, describing
A.J. Leggett, C. Hainzl, C. Hainzl, C. Hainzl, C. Hainzl, C.A.R. Sá de Melo, Christian Hainzl, D.S. Petrov, E.P. Gross, E.P. Gross, I. Bloch, J. Bardeen, L.P. Pitaevskii, M. Drechsler, M. Randeria, M. Reed, N.N. Bogoliubov, P. Nozières, R.B. Griffiths, R.L. Frank, Robert Seiringer, V.L. Ginzburg   +21 more
core   +1 more source

NGF signaling in PC12 cells: the cooperation of p75NTR with TrkA is needed for the activation of both mTORC2 and the PI3K signalling cascade

Biology Open, 2013
Summary PC12-27, a PC12 clone characterized by high levels of the transcription repressor REST and by very low mTORC2 activity, had been shown to be unresponsive to NGF, possibly because of its lack of the specific TrkA receptor.
Sara Negrini, Rosalba D'Alessandro, Jacopo Meldolesi   +2 more
doaj   +1 more source

Tyrosine kinase A, C and fibroblast growth factor-2 receptors in bovine embryos cultured in vitro [PDF]

, 2013
Neurotrophins and basic fibroblast growth factor are ligands of tyrosine kinase receptors, though they bind to different tyrosine kinase receptor classes.
Caamaño, J.N. (José), Díez, C., Facal, Nieves, Fernández-Sánchez, M.T. (M.), Frutos, C., Gómez, E., Muñoz, M., Pérez-Gómez, A., Rodríguez, A.   +8 more
core  

Evaluation and Characterization of Trk Kinase Inhibitors for the Treatment of Pain: Reliable Binding Affinity Predictions from Theory and Computation [PDF]

, 2017
Optimization of ligand binding affinity to the target protein of interest is a primary objective in small-molecule drug discovery. Until now, the prediction of binding affinities by computational methods has not been widely applied in the drug discovery ...
Bagal, SK, Bhati, AP, Coveney, PV, Omoto, K, Shanmugasundaram, V, Skerratt, S, Wan, S   +6 more
core   +1 more source

TrkA glycosylation regulates receptor localization and activity

Journal of Neurobiology, 1999
The human nerve growth factor receptor (TrkA) contains four potential N-glycosylation sites that are highly conserved within the Trk family of neurotrophin receptors, and nine additional sites that are less well conserved. Using a microscale deglycosylation assay, we show here that both conserved and variable N-glycosylation sites are used during ...
Watson, F. L., Porcionatto, Marimelia Aparecida UNIFESP, Bhattacharyya, A., Stiles, C. D., Segal, R. A.   +4 more
openaire   +2 more sources

Purification of TrkA intracellular domain and the characterization of novel intracellular proteins : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Science in Molecular Biology at Massey University [PDF]

, 1999
Nerve growth factor (NGF) binds to its receptor, TrkA, at the tips of nerve cell axons to inhibit apoptosis, causing survival and differentiation.
Walker, Scott David
core  

The glia response after peripheral nerve injury: A comparison between Schwann cells and olfactory ensheathing cells and their uses for neural regenerative therapies [PDF]

, 2017
The peripheral nervous system (PNS) exhibits a much larger capacity for regeneration than the central nervous system (CNS). One reason for this difference is the difference in glial cell types between the two systems.
Barton, Matthew J., Clarke, Mary, Ekberg, Jenny, St. John, James, Wright, Alison   +4 more
core   +2 more sources