Results 41 to 50 of about 1,251,047 (226)

Photosensitive tyrosine analogues unravel site-dependent phosphorylation in TrkA initiated MAPK/ERK signaling

Communications Biology, 2020
Using genetic code expansion, Zhao, Shi et al. generate light-sensitive tyrosine analogues to obtain insights into the activation of the NGF receptor, TrkA.
Shu Zhao, Jia Shi, Guohua Yu, Dali Li, Meng Wang, Chonggang Yuan, Huihui Zhou, Amirabbas Parizadeh, Zhenlin Li, Min-Xin Guan, Shixin Ye   +10 more
doaj   +1 more source

Novel mutations in UL24 and gH rescue efficient infection of an HSV vector retargeted to TrkA

Molecular Therapy: Methods & Clinical Development, 2023
Transductional targeting of herpes simplex virus (HSV)-based gene therapy vectors offers the potential for improved tissue-specific delivery and can be achieved by modification of the viral entry machinery to incorporate ligands that bind the desired ...
Marco Marzulli, Bonnie L. Hall, Mingdi Zhang, William F. Goins, Justus B. Cohen, Joseph C. Glorioso   +5 more
doaj   +1 more source

Nerve Growth Factor Receptor TrkA, a New Receptor in Insulin Signaling Pathway in PC12 cells [PDF]

, 2013
TrkA is a cell surface transmembrane receptor tyrosine kinase for nerve growth factor (NGF). TrkA has an NPXY motif and kinase regulatory loop similar to insulin receptor (INSR) suggesting that NGF→TrkA signaling might overlap with insulin→INSR signaling.
Geetha, Thangiah, Rege, Shraddha D., Meakin, Susan O., Mathews, Salome E., Babu, Jeganathan Ramesh, White, Morris F.   +5 more
core   +1 more source

Unlocking the potential of approved drugs for the allosteric inhibition of tropomyosin-receptor kinase A using molecular docking and molecular dynamics studies

Frontiers in Chemistry, 2023
Tropomyosin-receptor kinase A (TrkA) is the primary isoform among the tropomyosin-receptor kinases that have been associated with human cancer development, contributing to approximately 7.4% of all cancer cases.
Rua M. Mukhtar, Nihal Abdelmoniem, Hisham A. Elrufaie, Alaa Edris, Hiba Ghaboosh, Mohanad A. Mahgoub, Elrashied A. E. Garelnabi, Wadah Osman, Wadah Osman, Asmaa E. Sherif, Asmaa E. Sherif, Ahmed Ashour, Ahmed Ashour, Kholoud F. Ghazawi, Waad A. Samman, Aisha A. Alhaddad, Rawan Bafail, Sabrin R. M. Ibrahim, Sabrin R. M. Ibrahim, Gamal A. Mohamed, Abdulrahim A. Alzain   +20 more
doaj   +1 more source

Role of NGF/TrkA signaling milieu in depressogenic induction of rat brain [PDF]

Al Ameen Journal of Medical Sciences, 2013
Objectives: Stress-induced helplessness in rodents constitutes a well-defined model to investigate neurobiological mechanism of depression. In the present investigation, we investigated the correlation between stress induced helplessness and NGF, its ...
Ritabrata Banerjee, Anup K. Ghosh, Balaram Ghosh, Amal C. Mondal   +3 more
doaj  

Influenza A virus activates cellular Tropomyosin receptor kinase A (TrkA) signaling to promote viral replication and lung inflammation.

PLoS Pathogens, 2022
Influenza A virus (IAV) infection causes acute respiratory disease with potential severe and deadly complications. Viral pathogenesis is not only due to the direct cytopathic effect of viral infections but also to the exacerbated host inflammatory ...
Vikram Verma, Mythili Dileepan, Qinfeng Huang, Thu Phan, Wei-Shou Hu, Hinh Ly, Yuying Liang   +6 more
doaj   +1 more source

Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles

Scientific Reports, 2023
Proper wiring of the peripheral nervous system relies on neurotrophic signaling via nerve growth factor (NGF). NGF secreted by target organs (i.e. eye) binds to the TrkA receptor expressed on the distal axons of postganglionic neurons. Upon binding, TrkA
Ashley J. Mason, Austin B. Keeler, Farah Kabir, Bettina Winckler, Christopher Deppmann   +4 more
doaj   +1 more source

Computational Insights into the Sequence-Activity Relationships of the NGF(1–14) Peptide by Molecular Dynamics Simulations

Cells, 2022
The Nerve Growth Factor (NGF) belongs to the neurothrophins protein family involved in the survival of neurons in the nervous system. The interaction of NGF with its high-affinity receptor TrkA mediates different cellular pathways related to Alzheimer’s ...
Serena Vittorio, Candida Manelfi, Silvia Gervasoni, Andrea R. Beccari, Alessandro Pedretti, Giulio Vistoli, Carmine Talarico   +6 more
doaj   +1 more source

TrkA Receptor Endolysosomal Degradation is Both Ubiquitin and Proteasome Dependent [PDF]

Traffic, 2008
Gaps in our knowledge exist regarding the degradation of the tropomyosin‐regulated kinase A (TrkA) receptor after addition of neurotrophin, nerve growth factor (NGF). TrkA is rapidly and transiently ubiquitinated upon addition of NGF.
Thangiah, Geetha, Marie W, Wooten
openaire   +2 more sources

Nerve growth factor and Tropomyosin receptor kinase A are increased in the gastric mucosa of patients with functional dyspepsia

BMC Gastroenterology, 2019
Background Nerve growth factor (NGF) and enteric glial cells (EGCs) are associated with visceral hypersensitivity and gastrointestinal motility disorder, which may represent the pathogenesis of functional dyspepsia (FD).
Haitao Shi, Shanshan Zhu, Bin Qin, Lianli Wang, Juan Yang, Guolong Lu, Fei Dai   +6 more
doaj   +1 more source