Results 61 to 70 of about 1,251,047 (226)

NGF signaling in PC12 cells: the cooperation of p75NTR with TrkA is needed for the activation of both mTORC2 and the PI3K signalling cascade

Biology Open, 2013
Summary PC12-27, a PC12 clone characterized by high levels of the transcription repressor REST and by very low mTORC2 activity, had been shown to be unresponsive to NGF, possibly because of its lack of the specific TrkA receptor.
Sara Negrini, Rosalba D'Alessandro, Jacopo Meldolesi   +2 more
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Regulated Intramembrane Proteolysis of the p75 Neurotrophin Receptor Modulates Its Association with the TrkA Receptor [PDF]

Journal of Biological Chemistry, 2003
The generation of biologically active proteins by regulated intramembrane proteolysis is a highly conserved mechanism in cell signaling. Presenilin-dependent gamma-secretase activity is responsible for the intramembrane proteolysis of selected type I membrane proteins, including beta-amyloid precursor protein (APP) and Notch.
Jung, KM, Tan, S, L, man, N, Petrova, K, Murray, S, Lewis, R, Kim, PK, Kim, DS, Ryu, SH, Chao, MV, Kim, TW   +11 more
openaire   +3 more sources

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Emergence of functional sensory subtypes as defined by transient receptor potential channel expression [PDF]

, 2007
The existence of heterogeneous populations of dorsal root ganglion (DRG) neurons conveying different somatosensory information is the basis for the perception of touch, temperature, and pain. A differential expression of transient receptor potential (TRP)
Hjerling-Leffler, J, Ernfors, P, Ernfors, P,, Koltzenburg, M, AlQatari, M   +4 more
core   +1 more source

Local Administration of a Synthetic Cell-Penetrating Peptide Antagonizing TrkA Function Suppresses Inflammatory Pain in Rats

Journal of Pharmacological Sciences, 2010
Novel agents that inhibit nerve growth factor signaling are required for the treatment of inflammatory pain. The present study investigated the effect of local administration of inhibitory peptide of TrkA (IPTRK3), a synthetic cell-penetrating peptide ...
Koyo Ueda, Munetaka Hirose, Eri Murata, Mayumi Takatori, Masashi Ueda, Hiroshi Ikeda, Kenji Shigemi   +6 more
doaj   +1 more source

From Caffeine to Aspirin: Everyday Molecules as Triggers for Genetically Encoded Proximity Systems

Chemistry – A European Journal, EarlyView.
This Perspective article highlights how familiar dietary ingredients and over‐the‐counter (OTC) drugs (such as caffeine and its metabolites, SA, and aspirin) can be repurposed as clinically translatable chemical triggers for genetically encoded proximity systems.
Mingguang Cui, Tianlu Wang, Yaoyu Han, Yun Huang, Tien‐Hung Lan, Yunbin Zhou   +5 more
wiley   +1 more source

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source

A rich network of S100+/tropomyosin receptor kinase A+ nerve fibers in the connective tissue wall of radicular cysts: An immunohistochemical study of biopsy cases

Saudi Endodontic Journal
Introduction: Limited information is available regarding the presence of nerve fibres in human radicular granulomas and cysts. The aim of the present study was to map the neural network of human radicular cysts by the immunohistochemical expression of ...
Nikolaos P. Kerezoudis, Taxiarchis G. Kontogiannis, Konstantinos I. Tosios   +2 more
doaj   +1 more source

Chronic nerve growth factor exposure increases apoptosis in a model of in vitro induced conjunctival myofibroblasts. [PDF]

PLoS ONE, 2012
In the conjunctiva, repeated or prolonged exposure to injury leads to tissue remodeling and fibrosis associated with dryness, lost of corneal transparency and defect of ocular function.
Alessandra Micera, Ilaria Puxeddu, Bijorn Omar Balzamino, Stefano Bonini, Francesca Levi-Schaffer   +4 more
doaj   +1 more source